Archaeology and Intellectual Property Rights: CARARE - Project deliverable

This report aims to set out the complexities surrounding the use and re-use of archaeological data with regard to IPR, and provide best practice guidance on managing rights for archaeological content supplied to Europeana. This guidance has been developed in consultation with the CARARE network partners, and is meant to familiarise potential Europeana contributors with common scenarios, but cannot be considered legal advice

Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix

Bone metastases are a frequent cause of morbidity in cancer patients. The present palliative therapeutic options are chemotherapy, hormone therapy, and the administration of bisphosphonates. The affinity between bisphosphonates and the apatite structure of bone metastases is strong. Thus, we designed two low-molecular-weight and water-soluble prodrugs which incorporate a bisphosphonate group as a bone targeting ligand, doxorubicin as the anticancer agent, and either an acid-sensitive bond (<b>1</b>) or a cathepsin B cleavable bond (<b>3</b>) for ensuring an effective release of doxorubicin at the site of action. Cleavage studies of both prodrugs showed a fast release of doxorubicin but sufficient stability over several hours in human plasma. Effective binding of prodrug <b>1</b> and <b>3</b> was demonstrated with hydroxyapatite and with native bone. In orientating toxicity studies in nude mice, the MTD of <b>1</b> was 3-fold higher compared to conventional doxorubicin, whereas <b>3</b> showed essentially the same MTD as doxorubicin

Forest practitioners’ requirements for remote sensing-based canopy height, wood-volume, tree species, and disturbance products

Despite decades of development, the uptake of remote sensing-based information products in the forestry sector is still lagging behind in central and southern Europe. This may partly relate to a mismatch of the developed remote sensing products and the requirements of potential users. Here, we present the results of a questionnaire survey in which we questioned 355 forest practitioners from eight central and southern European countries. We aimed to learn about forest practitioners' technical requirements for four remote sensing-based information products, including information on tree species, canopy height, wood volume/biomass, and forest disturbances. We asked for practitioners’ preferences with respect to thematic and spatial detail as well as the maximal acceptable error and the temporal frequency with which the information layers would be needed. We then examined whether the education, age, and professional background affect the requirements. Preferences with respect to spatial and thematic detail were comparably diverse while more homogenous patterns could be observed for demands with respect to errors and temporal frequency. Our results indicate that for some information products such as canopy height maps, existing remote sensing technology, and workflows can match all demands of practitioners. Remotely sensed information on forest disturbances partly fulfils the demands of the practitioners while for products related to tree species and wood volume/biomass the level of thematic detail and the accuracy of the products demanded by practitioners in central and southern Europe is not yet fully matched. We found no statistically significant differences between the demographic groups examined. The findings of this study improve our understanding of matches and mismatches of the technical requirements of practitioners for remote sensing-based information product

Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

Identification and selectivity of molecular targets with prolonged action for difficult-to-target cancer such as triple-negative breast cancer (TNBC) represent a persisting challenge in the precision delivery of therapeutics. In the quest to target undruggable sites, this study validates the bioavailability of polydopamine-sealed mesoporous silica nanocarriers (PDA-mSiO2) for in vivo drug delivery to TNBC. For controlled transport and release, the chemotherapeutic drug doxorubicin was encapsulated in mSiO2 nanocarriers coated with a PDA layer serving as a stimuli-responsive gatekeeper or seal. For unifying targeting and treatment modalities, these nanocarriers were covalently conjugated to a macrocyclic chelator (DOTA) and folate (FA-mSiO2.) that enabled incorporation of radionuclides and identification of FR Alpha (FolRα) receptors present on TNBC cells. The robust chemical design of FA- and DOTA-functionalized PDA-coated mSiO2 nanocarriers constitutes mild reaction conditions to avoid the loss of surface-bound molecules. The radiolabeling studies with the theranostic pair 68Ga and 177Lu showed quantitative trends for radiochemical efficacy and purity. Nanocarriers equipped with both radiolabels and affinity ligands were optimally stable when incubated with human serum for up to 120 h (177Lu), demonstrating hydrophilicity with a partition coefficient (log P) of −3.29 ± 0.08. Specifically, when incubated with TNBC cells, the cells received significant FA-mSiO2 carriers, demonstrating efficient carrier internalization and time-dependent uptake. Moreover, in vivo results visualize the retention of drug-filled carriers at the tumor sites for a long time, which holds promise for therapeutic studies. This research work demonstrates for the first time the successful dual conjugation of nanocarriers through the colocation of radionuclides and anticancer drugs that is promising for both live molecular imaging and enhanced therapeutic effect for TNBC

Search for supersymmetry in hadronic final states with missing transverse energy using the variables αT and b-quark multiplicity in pp collisions at √s = 8 TeV

Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-27T11:30:34Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:48:49Z : No. of bitstreams: 1 2-s2.0-84883824987.pdf: 1540579 bytes, checksum: be6bbff5192436d9fcdbc367ffd1650e (MD5) Made available in DSpace on 2014-05-27T11:30:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-01 An inclusive search for supersymmetric processes that produce final states with jets and missing transverse energy is performed in pp collisions at a centre-of-mass energy of 8 TeV. The data sample corresponds to an integrated luminosity of 11.7 fb-1 collected by the CMS experiment at the LHC. In this search, a dimensionless kinematic variable, αT, is used to discriminate between events with genuine and misreconstructed missing transverse energy. The search is based on an examination of the number of reconstructed jets per event, the scalar sum of transverse energies of these jets, and the number of these jets identified as originating from bottom quarks. No significant excess of events over the standard model expectation is found. Exclusion limits are set in the parameter space of simplified models, with a special emphasis on both compressed-spectrum scenarios and direct or gluino-induced production of third-generation squarks. For the case of gluino-mediated squark production, gluino masses up to 950-1125 GeV are excluded depending on the assumed model. For the direct pair-production of squarks, masses up to 450 GeV are excluded for a single light first- or second-generation squark, increasing to 600 GeV for bottom squarks. © 2013 CERN for the benefit of the CMS collaboration. CERN, Geneva Yerevan Physics Institute, Yerevan Institut für Hochenergiephysik der OeAW, Wien National Centre for Particle and High Energy Physics, Minsk Universiteit Antwerpen, Antwerpen Vrije Universiteit Brussel, Brussel Université Libre de Bruxelles, Bruxelles Ghent University, Ghent Université Catholique de Louvain, Louvain-la-Neuve Université de Mons, Mons Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro Universidade do Estado do Rio de Janeiro, Rio de Janeiro Universidade Estadual Paulista, São Paulo Universidade Federal do ABC, São Paulo Institute for Nuclear Research and Nuclear Energy, Sofia University of Sofia, Sofia Institute of High Energy Physics, Beijing State Key Laboratory of Nuclear Physics and Technology Peking University, Beijing Universidad de Los Andes, Bogota Technical University of Split, Split University of Split, Split Institute Rudjer Boskovic, Zagreb University of Cyprus, Nicosia Charles University, Prague Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics, Cairo National Institute of Chemical Physics and Biophysics, Tallinn Department of Physics University of Helsinki, Helsinki Helsinki Institute of Physics, Helsinki Lappeenranta University of Technology, Lappeenranta DSM/IRFU CEA/Saclay, Gif-sur-Yvette Laboratoire Leprince-Ringuet, Ecole Polytechnique IN2P3-CNRS, Palaiseau Institut Pluridisciplinaire Hubert Curien, Universite de Strasbourg, Universite de Haute Alsace Mulh CNRS/IN2P3, Strasbourg CNRS-IN2P3, Institut de Physique Nucléaire de Lyon Université de Lyon, Université Claude Bernard Lyon 1, Villeurbanne Institute of High Energy Physics and Informatization Tbilisi State University, Tbilisi I. Physikalisches Institut RWTH Aachen University, Aachen III. Physikalisches Institut A RWTH Aachen University, Aachen III. Physikalisches Institut B RWTH Aachen University, Aachen Deutsches Elektronen-Synchrotron, Hamburg University of Hamburg, Hamburg Institut für Experimentelle Kernphysik, Karlsruhe Institute of Nuclear and Particle Physics (INPP) NCSR Demokritos, Aghia Paraskevi University of Athens, Athens University of Ioánnina, Ioánnina KFKI Research Institute for Particle and Nuclear Physics, Budapest Institute of Nuclear Research ATOMKI, Debrecen University of Debrecen, Debrecen Panjab University, Chandigarh University of Delhi, Delhi Saha Institute of Nuclear Physics, Kolkata Bhabha Atomic Research Centre, Mumbai Tata Institute of Fundamental Research - EHEP, Mumbai Tata Institute of Fundamental Research - HECR, Mumbai Institute for Research in Fundamental Sciences (IPM), Tehran INFN Sezione di Bari, Bari Università di Bari, Bari Politecnico di Bari, Bari INFN Sezione di Bologna, Bologna Università di Bologna, Bologna INFN Sezione di Catania, Catania Università di Catania, Catania INFN Sezione di Firenze, Firenze Università di Firenze, Firenze INFN Laboratori Nazionali di Frascati, Frascati INFN Sezione di Genova, Genova Università di Genova, Genova INFN Sezione di Milano-Bicocca, Milano Università di Milano-Bicocca, Milano INFN Sezione di Napoli, Napoli Università di Napoli 'Federico II', Napoli Università della Basilicata (Potenza), Napoli Università G. 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Lebedev Physical Institute, Moscow Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State University, Moscow State Research Center of Russian Federation Institute for High Energy Physics, Protvino Faculty of Physics and Vinca Institute of Nuclear Sciences University of Belgrade, Belgrade Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid Universidad Autónoma de Madrid, Madrid Universidad de Oviedo, Oviedo Instituto de Física de Cantabria (IFCA) CSIC-Universidad de Cantabria, Santander European Organization for Nuclear Research CERN, Geneva Paul Scherrer Institut, Villigen Institute for Particle Physics ETH Zurich, Zurich Universität Zürich, Zurich National Central University, Chung-Li National Taiwan University (NTU), Taipei Chulalongkorn University, Bangkok Cukurova University, Adana Physics Department Middle East Technical University, Ankara Bogazici University, Istanbul Istanbul Technical University, Istanbul National Scientific Center Kharkov Institute of Physics and Technology, Kharkov University of Bristol, Bristol Rutherford Appleton Laboratory, Didcot Imperial College, London Brunel University, Uxbridge Baylor University, Waco The University of Alabama, Tuscaloosa Boston University, Boston Brown University, Providence University of California, Davis, Davis University of California, Los Angeles University of California, Riverside, Riverside University of California, San Diego, La Jolla University of California, Santa Barbara, Santa Barbara California Institute of Technology, Pasadena Carnegie Mellon University, Pittsburgh University of Colorado at Boulder, Boulder Cornell University, Ithaca Fairfield University, Fairfield Fermi National Accelerator Laboratory, Batavia University of Florida, Gainesville Florida International University, Miami Florida State University, Tallahassee Florida Institute of Technology, Melbourne University of Illinois at Chicago (UIC), Chicago The University of Iowa, Iowa City Johns Hopkins University, Baltimore The University of Kansas, Lawrence Kansas State University, Manhattan Lawrence Livermore National Laboratory, Livermore University of Maryland, College Park Massachusetts Institute of Technology, Cambridge University of Minnesota, Minneapolis University of Mississippi, Oxford University of Nebraska-Lincoln, Lincoln State University of New York at Buffalo, Buffalo Northeastern University, Boston Northwestern University, Evanston University of Notre Dame, Notre Dame The Ohio State University, Columbus Princeton University, Princeton University of Puerto Rico, Mayaguez Purdue University, West Lafayette Purdue University Calumet, Hammond Rice University, Houston University of Rochester, Rochester The Rockefeller University, New York Rutgers The State University of New Jersey, Piscataway University of Tennessee, Knoxville Texas A and M University, College Station Texas Tech University, Lubbock Vanderbilt University, Nashville University of Virginia, Charlottesville Wayne State University, Detroit University of Wisconsin, Madison Universidade Estadual Paulista, São Paul