Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

Spatial variation of flow characteristics in a subarctic meandering river in ice‐covered and open‐channel conditions: A 2D hydrodynamic modelling approach

To be able to understand year-round river channel evolution both at present and in the future, the spatial variation of the flow characteristics and their sediment transport capabilities under ice cover need to be detected. As the measurements done through cross-sectional drill holes cover only a small portion of the river channel area, the numerical simulations give insight into the wider spatial horizontal variation of the flow characteristics. Therefore, we simulate the ice-covered flow with a hydrodynamic two-dimensional (2D) model in a meandering subarctic river (Pulmanki River, Finland) in mid-winter conditions and compare them to the pre-winter open-channel low flow situation. Based on the simulations, which are calibrated with reference measurements, we aim to detect (1) how ice-covered mid-winter flow characteristics vary spatially and (2) the erosion and sedimentation potential of the ice-covered flow compared to open-channel conditions. The 2D hydrodynamic model replicated the observed flow characteristics in both open-channel and ice-covered conditions. During both seasons, the greatest erosional forces locate in the shallow sections. The narrow, freely flowing channel area found in mid-winter cause the main differences in the spatial flow variation between seasons. Despite the causes of the horizontal recirculating flow structures being similar in both seasons, the structures formed in different locations depended on whether the river was open or ice covered. The critical thresholds for particle entrainment are exceeded more often in open-channel conditions than during ice-covered flow. The results indicate spatially extensive sediment transport in open-channel conditions, but that the spatial variability and differences in depositional and erosional locations increase in ice-covered conditions. Asymmetrical bends and straight reaches erode throughout the year, whereas symmetrical, smaller bends mainly erode in open-channel conditions and are prone to deposition in winter. The long ice-covered season can greatly affect the annual morphology of the submerged channel

Racial Differences in Growth Patterns of Children Assessed on the Basis of Bone Age1

Our results show the cross-racial differences between the skeletal growth patterns of Asian and Hispanic children and skeletal growth patterns of white and African American children

Exchange of heavy metals between sediment components and water

(...) The composition of interstitial waters in sediments is perhaps the most sensitive indicator of the types and the extent of reactions that take place between pollutant-loaded sediment particles and the aqueous phase that contacts them. The large surface area of fine-grained sediment in relation to the small volume of its trapped interstitial water ensures that minor reactions with the solid phases will be shown by major changes in the composition of the aqueous phase