647 research outputs found
Emotional expression during attention-deficit/hyperactivity disorders treatment: initial assessment of treatment effects.
OBJECTIVE: The purpose of this research was to provide an initial examination of the effects of atomoxetine and stimulants on emotional expression using a newly developed scale for assessing emotional expression in children with attention-deficit/hyperactivity disorder (ADHD).
METHOD: The parent-rated Expression and Emotion Scale for Children (EESC) was collected during two studies. During a cross-sectional validation study, the EESC was completed to assess the child\u27s current treatment and retrospectively for previous medication. In a randomized, placebo-controlled trial of atomoxetine, the EESC was collected at baseline and endpoint.
RESULTS: In the validation study, no statistically significant differences in EESC scores were found between groups taking atomoxetine (n = 74) and stimulants (n = 105). Patients who switched from a stimulant to atomoxetine (n = 40) had greater improvement in emotional expression than those switched to another stimulant (n = 21) (p = 0.008). In the clinical trial, no difference in rates of worsening of emotional expression were observed (atomoxetine 8.8%, placebo 12.3%; p = 0.440).
CONCLUSION: No treatment differences in emotional expression were observed based on current medications. However, stimulant patients needing to switch medications may have greater improvements in emotional expression by switching to atomoxetine
Bond-disordered spin systems: Theory and application to doped high-Tc compounds
We examine the stability of magnetic order in a classical Heisenberg model
with quenched random exchange couplings. This system represents the spin
degrees of freedom in high- compounds with immobile dopants.
Starting from a replica representation of the nonlinear -model, we
perform a renormalization-group analysis. The importance of cumulants of the
disorder distribution to arbitrarily high orders necessitates a functional
renormalization scheme. From the renormalization flow equations we determine
the magnetic correlation length numerically as a function of the impurity
concentration and of temperature. From our analysis follows that
two-dimensional layers can be magnetically ordered for arbitrarily strong but
sufficiently diluted defects. We further consider the dimensional crossover in
a stack of weakly coupled layers. The resulting phase diagram is compared with
experimental data for LaSrCuO.Comment: 12 pages, 5 figure
Ethics of controlled human infection to study COVID-19
Development of an effective vaccine is the clearest path to controlling the coronavirus disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some researchers are pursuing, and thousands of people have expressed interest in participating in, controlled human infection studies (CHIs) with severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) (1, 2). In CHIs, a small number of participants are deliberately exposed to a pathogen to study infection and gather preliminary efficacy data on experimental vaccines or treatments. We have been developing a comprehensive, state-of-the-art ethical framework for CHIs that emphasizes their social value as fundamental to justifying these studies. The ethics of CHIs in general are underexplored (3, 4), and ethical examinations of SARS-CoV-2 CHIs have largely focused on whether the risks are acceptable and participants could give valid informed consent (1). The high social value of such CHIs has generally been assumed. Based on our framework, we agree on the ethical conditions for conducting SARS-CoV-2 CHIs (see the table). We differ on whether the social value of such CHIs is sufficient to justify the risks at present, given uncertainty about both in a rapidly evolving situation; yet we see none of our disagreements as insurmountable. We provide ethical guidance for research sponsors, communities, participants, and the essential independent reviewers considering SARS-CoV-2 CHIs
Measurement of Exclusive Electroproduction Structure Functions and their Relationship to Transversity GPDs
Exclusive electroproduction at a beam energy of 5.75 GeV has been
measured with the Jefferson Lab CLAS spectrometer. Differential cross sections
were measured at more than 1800 kinematic values in , , , and
, in the range from 1.0 to 4.6 GeV,\ up to 2 GeV,
and from 0.1 to 0.58. Structure functions and were extracted as functions of for each of
17 combinations of and . The data were compared directly with two
handbag-based calculations including both longitudinal and transversity GPDs.
Inclusion of only longitudinal GPDs very strongly underestimates and fails to account for and ,
while inclusion of transversity GPDs brings the calculations into substantially
better agreement with the data. There is very strong sensitivity to the
relative contributions of nucleon helicity flip and helicity non-flip
processes. The results confirm that exclusive electroproduction offers
direct experimental access to the transversity GPDs.Comment: 6 pages, 2 figure
A comparison of forward and backward pp pair knockout in 3He(e,e'pp)n
Measuring nucleon-nucleon Short Range Correlations (SRC) has been a goal of
the nuclear physics community for many years. They are an important part of the
nuclear wavefunction, accounting for almost all of the high-momentum strength.
They are closely related to the EMC effect. While their overall probability has
been measured, measuring their momentum distributions is more difficult. In
order to determine the best configuration for studying SRC momentum
distributions, we measured the He reaction, looking at events
with high momentum protons ( GeV/c) and a low momentum neutron
( GeV/c). We examined two angular configurations: either both protons
emitted forward or one proton emitted forward and one backward (with respect to
the momentum transfer, ). The measured relative momentum distribution
of the events with one forward and one backward proton was much closer to the
calculated initial-state relative momentum distribution, indicating that
this is the preferred configuration for measuring SRC.Comment: 8 pages, 9 figures, submitted to Phys Rev C. Version 2 incorporates
minor corrections in response to referee comment
Effects of atomoxetine on growth in children with attention-deficit/hyperactivity disorder following up to five years of treatment.
OBJECTIVE: To examine the effects on growth of long-term pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), we present findings from an ongoing 5-year study of the efficacy and safety of treatment with atomoxetine.
METHODS: North American patients, 6-17 years old at study entry (N = 1,312) and with Diagnostic and Statistical Manual of Mental Disorders,4th edition (DSM-IV) ADHD, were studied under open-label atomoxetine treatment. Sixty-one were studied up to 5 years.
RESULTS: After 1 month\u27s treatment, patients weighed less than expected from their starting percentiles relative to population norms, with a maximum shortfall at 15 months and a return to expected weight by 36 months. Patients were slightly shorter than expected after 12 months, reaching a maximum shortfall at 18 months and returning to expected height by 24 months. Patients in the top quartile for body mass index (BMI) or weight at baseline, and those in the third quartile for height, showed 5-year decreases from expected values. Those below median height at baseline showed increases relative to expected values.
CONCLUSIONS: These interim results indicate that continuous atomoxetine treatment for up to 5 years has little or no long-term effect on juvenile growth and final stature for most patients, although persistent decreases from expected may occur in some patients who are larger than average before treatment
Gravitational wave extraction and outer boundary conditions by perturbative matching
We present a method for extracting gravitational radiation from a
three-dimensional numerical relativity simulation and, using the extracted
data, to provide outer boundary conditions. The method treats dynamical
gravitational variables as nonspherical perturbations of Schwarzschild
geometry. We discuss a code which implements this method and present results of
tests which have been performed with a three dimensional numerical relativity
code
Boosted three-dimensional black-hole evolutions with singularity excision
Binary black hole interactions provide potentially the strongest source of
gravitational radiation for detectors currently under development. We present
some results from the Binary Black Hole Grand Challenge Alliance three-
dimensional Cauchy evolution module. These constitute essential steps towards
modeling such interactions and predicting gravitational radiation waveforms. We
report on single black hole evolutions and the first successful demonstration
of a black hole moving freely through a three-dimensional computational grid
via a Cauchy evolution: a hole moving ~6M at 0.1c during a total evolution of
duration ~60M
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