Factors affecting mortality in late stage Parkinson’s Disease

To determine the effect of dysphagia and hospital admissions on mortality in late stage Parkinson’s disease

CLUMP-3D. Testing Λ\LambdaCDM with galaxy cluster shapes

The $\Lambda$CDM model of structure formation makes strong predictions on concentration and shape of DM (dark matter) halos, which are determined by mass accretion processes. Comparison between predicted shapes and observations provides a geometric test of the $\Lambda$CDM model. Accurate and precise measurements needs a full three-dimensional analysis of the cluster mass distribution. We accomplish this with a multi-probe 3D analysis of the X-ray regular CLASH (Cluster Lensing And Supernova survey with Hubble) clusters combining strong and weak lensing, X-ray photometry and spectroscopy, and the Sunyaev-Zel'dovich effect. The cluster shapes and concentrations are consistent with $\Lambda$CDM predictions. The CLASH clusters are randomly oriented, as expected given the sample selection criteria. Shapes agree with numerical results for DM-only halos, which hints at baryonic physics being not so effective in making halos rounder.Comment: v2: 8 pages, in press on ApJL. Extended discussion on regularity. One of three new companion papers of the CLUMP-3D project (Keiichi Umetsu et al., arxiv:1804.00664; I-Non Chiu et al., arXiv:1804.00676

Bolocam Survey for 1.1 mm Dust Continuum Emission in the c2d Legacy Clouds. II. Ophiuchus

We present a large-scale millimeter continuum map of the Ophiuchus molecular cloud. Nearly 11 square degrees, including all of the area in the cloud with visual extinction more than 3 magnitudes, was mapped at 1.1 mm with Bolocam on the Caltech Submillimeter Observatory (CSO). By design, the map also covers the region mapped in the infrared with the Spitzer Space Telescope. We detect 44 definite sources, and a few likely sources are also seen along a filament in the eastern streamer. The map indicates that dense cores in Ophiuchus are very clustered and often found in filaments within the cloud. Most sources are round, as measured at the half power point, but elongated when measured at lower contour levels, suggesting spherical sources lying within filaments. The masses, for an assumed dust temperature of 10 K, range from 0.24 to 3.9 solar masses, with a mean value of 0.96 solar masses. The total mass in distinct cores is 42 solar masses, 0.5 to 2% of the total cloud mass, and the total mass above 4 sigma is about 80 solar masses. The mean densities in the cores are quite high, with an average of 1.6 x 10^6 per cc, suggesting short free-fall times. The core mass distribution can be fitted with a power law with slope of 2.1 plus or minus 0.3 for M>0.5 solar masses, similar to that found in other regions, but slightly shallower than that of some determinations of the local IMF. In agreement with previous studies, our survey shows that dense cores account for a very small fraction of the cloud volume and total mass. They are nearly all confined to regions with visual extinction at least 9 mag, a lower threshold than found previously.Comment: 47 pages, 16 figures, accepted for Ap

HTR4 gene structure and altered expression in the developing lung

Background: Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT4R) gene (HTR4) associated with lung function. The aims of this study were to i) investigate the expression profile of HTR4 in adult and fetal lung tissue and cultured airway cells, ii) further define HTR4 gene structure and iii) explore the potential functional implications of key SNPs using a bioinformatic approach

Microwave Kinetic Inductance Detector (MKID) Camera Testing for Submillimeter Astronomy

Developing kilopixel focal planes for incoherent submm- and mm-wave detectors remains challenging due to either the large hardware overhead or the complexity of multiplexing standard detectors. Microwave kinetic inductance detectors (MKIDs) provide a efficient means to produce fully lithographic background-limited kilopixel focal planes. We are constructing an MKID-based camera for the Caltech Submillimeter Observatory with 576 spatial pixels each simultaneously sensitive in 4 bands at 230, 300, 350, and 400 GHz. The novelty of MKIDs has required us to develop new techniques for detector characterization. We have measured quasiparticle lifetimes and resonator Qs for detector bath temperatures between 200 mK and 400 mK. Equivalent lifetime measurements were made by coupling energy into the resonators either optically or by driving the third harmonic of the resonator. To determine optical loading, we use both lifetime and internal Q measurements, which range between 15,000 and 30,000 for our resonators. Spectral bandpass measurements confirm the placement of the 230 and 350 GHz bands. Additionally, beam maps measurements conform to expectations. The same device design has been characterized on both sapphire and silicon substrates, and for different detector geometries. We also report on the incorporation of new shielding to reduce detector sensitivity to local magnetic fields

CLUMP-3D: three-dimensional lensing and multi-probe analysis of MACS J1206.2−0847, a remarkably regular cluster

Multi-wavelength techniques can probe the distribution and the physical properties of baryons and dark matter in galaxy clusters from the inner regions out to the peripheries. We present a full three-dimensional analysis combining strong and weak lensing, X-ray surface brightness and temperature, and the Sunyaev–Zel'dovich effect. The method is applied to MACS J1206.2−0847, a remarkably regular, face-on, massive, M_(200) = (1.1 ± 0.2) × 10^(15) M⊙ h^(−1), cluster at z = 0.44. The measured concentration, c_(200) = 6.3 ± 1.2, and the triaxial shape are common to haloes formed in a Λ cold dark matter scenario. The gas has settled in and follows the shape of the gravitational potential, which is evidence of pressure equilibrium via the shape theorem. There is no evidence for significant non-thermal pressure and the equilibrium is hydrostatic