D4.4 - Final Version of Game Applications for Scenario Pilots

This final report provides an overview of the final versions of the RAGE games made using the RAGE assets after the first round of pilot testing and formative evaluation. The document serves as internal communication and discussion in RAGE among game companies and asset developers together with case owners and evaluators. The document is structured as follows: each game is contained in its own section, which is then divided into a section covering a short overview, a section on changes since initial version (presented in D4.3), a section on the use of RAGE components and a section providing actual game screenshots from the latest version of the game, together with narrated description

D4.3 – Initial version of game applications for scenario pilots

This intermediate report provides an overview of the current versions of the RAGE games made using the RAGE assets for the first round of pilot testing and formative evaluation. The document serves as internal communication and discussion in RAGE among game companies and asset developers together with case owners and evaluators. Whilst detailed description of the design of the games, together with their learning outcomes and piloting can be found in D4.2 and D5.1, updates and changes to the designs, game flow and use of assets are included here.This study is part of the RAGE project. The RAGE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 644187. This publication reflects only the author's view. The European Commission is not responsible for any use that may be made of the information it contains

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety

The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins