Symmetries and local transformations of translationally invariant Matrix Product States

We determine the local symmetries and local transformation properties of translationally invariant matrix product states (MPS). We focus on physical dimension $d=2$ and bond dimension $D=3$ and use the procedure introduced in D. Sauerwein et al., Phys. Rev. Lett. 123, 170504 (2019) to determine all (including non--global) symmetries of those states. We identify and classify the stochastic local transformations (SLOCC) that are allowed among MPS. We scrutinize two very distinct sets of MPS and show the big diversity (also compared to the case $D=2$) occurring in both, their symmetries and the possible SLOCC transformations. These results reflect the variety of local properties of MPS, even if restricted to translationally invariant states with low bond dimension. Finally, we show that states with non-trivial local symmetries are of measure zero for $d = 2$ and $D > 3$.Comment: 40 pages, 5 figure

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites

A highly effective vaccine that confers sterile protection to malaria is urgently needed. Immunization under chemoprophylaxis with sporozoites (CPS) consistently confers high levels of protection in the Controlled Human Malaria infection (CHMI) model. To provide a broad, unbiased assessment of the composition and kinetics of direct ex vivo human immune responses to CPS, we profiled whole-blood transcriptomes by RNA-seq before and during CPS immunization and following CHMI challenge. Differential expression of genes enriched in modules related to T cells, NK cells, protein synthesis, and mitochondrial processes were detected in fully protected individuals four weeks after the first immunization. Non-protected individuals demonstrated transcriptomic changes after the third immunization and the day of treatment, with upregulation of interferon and innate inflammatory genes and downregulation of B-cell signatures. Protected individuals demonstrated more significant interactions between blood transcription modules compared to non-protected individuals several weeks after the second and third immunizations. These data provide insight into the molecular and cellular basis of CPS-induced immune protection from P. falciparum infection

Applied Remote Sensing Program (ARSP)

There are no author-identified significant results in this report