Investigation of oxidative potential of mahasudarshan churna using goat liver as in-vitro experimental model

The American Medical Research Community sounded a heavy metal warning against some herbo-mineral Ayurvedic formulations from Indian System of Medicine sold in United States of America. The products were rejected by Unites States Food and Drug Administration due to the presence of high level of lead, mercury and arsenic as impurities, marked as toxicity inducers. This work has been design to investigate whether the toxicity produced by Mahasudarshan churna is due to the results of lipid peroxidation, as oxidative degradation of phospholipids is one of the causes of drug-induced toxicity. The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and only antioxidant-treated group at two hours and six hours of incubation time in goat liver homogenates. Ascorbic acid was used to compare the oxidative potentials of Mahasudarshan churna. The level of malondialdehyde was found to be decreased in the drug-treated, drug-antioxidant treated and only antioxidant treated group where as the level of reduced glutathione and nitric oxide increased when compared to control. Above all the Drug-antioxidant treated group showed maximum anti-oxidant properties when compared to other groups. The study was designed to investigate the lipid peroxidation induction capacity of Mahasudarshan churna as consequences of its toxicity and found that lipid peroxidation is not the contributing facto

Antihyperlipidemic potential of herbals

One of the most widespread diseases in the world is Coronary Heart Disease (CHD). It is also one of the most preventable. This review explores the management of CHD through changes in dietary modifications, lifestyle, and the use of dietary supplements and botanical

Clock gene variation in type 2 diabetes: a review

Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone. Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clock

A review of wound healing activity on different wound models

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and their function. The normal wounds start to heal immediately after an injury. Normal healing process involved: inflammatory phase, proliferation phase and maturation phase. Now a day wound healing is a challenging clinical problem. So, necessity of effective wound management is required. The various screening models play important role to understand the basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. Ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture and the  in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model.The aim of this review article is detailed study of different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity

Ethnomedicinal plants in Chhattisgarh origin

The survey on Ethano medicinal plant of Chhattisgarh origin has been carried out to gather information regarding potent medicinal plants and their uses. The survey report is focused on traditional practice ethnic natural resources for mitigation and cure from several ailments. Even today, these herbal medicines are in practice to cure variety of disease. The present investigation was conducted using questionnaire in rural areas situated around in Chhattisgarh. Traditional knowledge about plant wealth passes from generation to generation for conservation of the traditional medicine

Evaluation of anxiolytic potential of Linum usitatissimum oil in wistar rats

The objective of the present study was to evaluate the anxiolytic potential of the Linum usitatissimum (Flax seed) oil (5ml and 2.5ml/kg) in wistar rats by using Elevated plus maze (EPM) model and 5ml and 10 ml/kg in Lithium induced head twitches model. Experiments were carried out on white inbred Wistar rats (180-200 g). The efficacy of the oil at both the animal models was compared with the standard anxiolytic drugs Diazepam (0.5 mg/kg). The result showed that the oil significantly increased the number of entries and time spent in the open arm in the elevated plus maze. Similarly in Lithium induced head twitches model administration of oil decreases the no. of head twitches. Present study confirms that the extract showed significant anxiolytic activity at both dose levels which is comparable with standard anxiolytic Diazepam

A mini review of methods to control ticks population infesting cattle in Chhattisgarh with special emphasis on herbal acaricides

217-223Ticks infestation is a major concern for the cattle industry in India. In Chhattisgarh, Hyalomma anatolicum and Rhipicephalus microplus are the two main ixodid tick affecting the animals. Ticks cause deterioration of the animal’s health and reduce their productivity. Controlling ticks is very much required for maintaining the wellbeing of animals and earning the livelihood by cattle rearing communities. The chemical acaricides have been used extensively for their promising results in controlling cattle ticks. However, these chemicals are comprised of certain side effects including reduction of meat quality, residues in body and affecting the environment. Most importantly, the ticks are getting resistant with almost all synthetic acaricides available in the market. Several organochlorine chemicals are banned due to their toxic effects. Chhattisgarh is the herbal state, numerous medicinal plants are growing in this geographical region that can be used as an effective and safe alternative to chemical acaricides against cattle ticks. Thus, in this review, we have introduced the type of ticks available in the Chhattisgarh. The possibility of herbal sources and other methods of controlling cattle ticks is also discussed

Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes

A mini review of methods to control ticks population infesting cattle in Chhattisgarh with special emphasis on herbal acaricides

Ticks infestation is a major concern for the cattle industry in India. In Chhattisgarh, Hyalomma anatolicum and Rhipicephalus microplus are the two main ixodid tick affecting the animals. Ticks cause deterioration of the animal’s health and reduce their productivity. Controlling ticks is very much required for maintaining the wellbeing of animals and earning the livelihood by cattle rearing communities. The chemical acaricides have been used extensively for their promising results in controlling cattle ticks. However, these chemicals are comprised of certain side effects including reduction of meat quality, residues in body and affecting the environment. Most importantly, the ticks are getting resistant with almost all synthetic acaricides available in the market. Several organochlorine chemicals are banned due to their toxic effects. Chhattisgarh is the herbal state, numerous medicinal plants are growing in this geographical region that can be used as an effective and safe alternative to chemical acaricides against cattle ticks. Thus, in this review, we have introduced the type of ticks available in the Chhattisgarh. The possibility of herbal sources and other methods of controlling cattle ticks is also discussed

Pharmacological evaluation for anti-bacterial and anti-inflammatory potential of polymeric microparticles

The objective of the study was to evaluate anti-bacterial and anti-Inflammatory activities of polymeric microparticles. In vitro antibacterial activity was performed for prepared microparticles followed by in vivo anti-inflammatory activity on rats. From the present study, it was observed that the microparticles developed were appropriate in their shape and uniform size. The topography of SEM studies revealed that, the microparticles were smooth-surfaced. The result of antibacterial activity indicated that the formulation has not exhibited any zone of inhibition against the various strains of bacteria used for this study. The result of anti-inflammatory activity (Dextran induced paw edema) exhibits that, the formulations possess the inhibitory potential for various inflammatory mediators thereby reduces the inflammation in paws. From the results, it can be concluded that Acacia arabica microparticles is showing significant Anti-inflammatory activity after 6 h than conventional dosage form