Influence of myopotential interference on the Wavelet discrimination algorithm in implantable cardioverter-defibrillator

Background: Wavelet is a morphology-based algorithm for detecting ventricular tachycardia. The electrogram (EGM) source of the Wavelet algorithm is nominally programmed with the Can-RV coil configuration, which records a far-field ventricular potential. Therefore, it may be influenced by myopotential interference. Methods: We performed a retrospective review of 40 outpatients who had an implantable cardioverter-defibrillator (LCD) with the Wavelet algorithm. The percent-match score of the Wavelet algorithm was measured during the isometric chest press by pressing the palms together. We classified patients with percent-match scores below 70% due to myopotential interference as positive morphology change, and those with 70% or more as negative morphology change. Stored episodes of tachycardia were evaluated during the follow-up. Results: The number of patients in the positive morphology change group was 22 (55%). Amplitude of the Can-RV coil EGM was lower in the positive morphology change group compared to that in the negative group (3.9 +/- 1.3 mV vs. 7.4 +/- 1.6 mV, P=0.0015). The cut-off value of the Can-RV coil EGM was 5 mV (area under curve, 0.89). Inappropriate detections caused by myopotential interference occurred in two patients (5%) during a mean follow-up period of 49 months, and one of them received an inappropriate LCD shock. These patients had exhibited positive morphology change. Conclusions: The Wavelet algorithm is influenced by myopotential interference when the Can-RV coil EGM is less than 5 mV

Efficacy of human resource development program for young industry personnel who will be involved in future medical device development

Background: Training next-generation personnel from small/medium enterprises (SMEs) is an urgent issue in promoting medical device research and development (R&D). Since 2014 we have engaged in governmentally funded human resource development program for medical/non-medical SMEs, and have assessed its effectiveness by analyzing self-evaluation of achievement level (SEAL) data obtained before and after the training course. Methods: Human resource development experts interviewed 34 key opinion leaders with deep knowledge of medical device R&D from industry, government, and academia. The skills required for R&D personnel were written down, and a set of skills was created by making a greatest common measure in the list of common elements among them. Using that skill sets, skill evaluations were conducted on trainees at “Osaka University Training Course,” twice before participation and after completion of the entire program using SEAL assessment. Results: There were 97 men and 25 women, with one-third in the’30 s. Among them, 61 participants (50%) were from R&D divisions, and 32 (26%) were from business/sales divisions. 94 (77%) were from medical SMEs, and 28 (23%) were from non-medical SMEs (new entry). After completing the training course, significant growth was observed in every item of both Soft and Hard skill sets. Especially in new entry SME members, a striking improvement was observed in practical medical knowledge to enhance communication with medical doctors (p < 0.0001). Conclusion: Our training course, though 7-day-short in total, showed that both Soft and Hard skills could be improved in young medical/non-medical SME members. Further assessment is needed to establish the necessary skill sets for our future partners from industries, to foster the creation of innovative medical devices through med-tech collaboration.The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: https://doi.org/10.1007/s00464-023-10474-

Measurements of 0.2 to 20 GeV/n cosmic-ray proton and helium spectra from 1997 through 2002 with the BESS spectrometer

We measured low energy cosmic-ray proton and helium spectra in the kinetic energy range 0.215 - 21.5 GeV/n at different solar activities during a period from 1997 to 2002. The observations were carried out with the BESS spectrometer launched on a balloon at Lynn Lake, Canada. A calculation for the correction of secondary particle backgrounds from the overlying atmosphere was improved by using the measured spectra at small atmospheric depths ranging from 5 through 37 g/cm^2. The uncertainties including statistical and systematic errors of the obtained spectra at the top of atmosphere are 5-7 % for protons and 6-9 % for helium nuclei in the energy range 0.5 - 5 GeV/n.Comment: 27 pages, 7 Tables, 9 figures, Submitted to Astroparticle Physic

Novel erythrocyte pits in small tropical ruminant, lesser mouse deer.

We examined unique erythrocyte pits of the peripheral blood and bone marrow in the lesser mouse deer, Tragulus javanicus, using scanning electron microscope (SEM) and transmission electron microscope (TEM). Under the SEM observation, the pit was observed as a hole on both mature erythrocytes of the peripheral blood and immature erythrocytes of the bone marrow. By the TEM, the mature erythrocytes had a vacuole, which showed complicated shape and occupied considerable space within the cytoplasm. The vacuole was communicated extracellularly by perforation, which corresponded to the hole on the cell surface. In the bone marrow, erythroblast and reticulocytes have a cytoplasmic vacuole. This abnormal feature of the erythrocytes is peculiar to the mouse deer, and not found in other tropical ruminants. Despite the disadvantage of volume loss from the small erythrocytes, the mouse deer were healthy and showed no signs of anaemia

Equation of state in the PNJL model with the entanglement interaction

The equation of state and the phase diagram in two-flavor QCD are investigated by the Polyakov-loop extended Nambu--Jona-Lasinio (PNJL) model with an entanglement vertex between the chiral condensate and the Polyakov-loop. The entanglement-PNJL (EPNJL) model reproduces LQCD data at zero and finite chemical potential better than the PNJL model. Hadronic degrees of freedom are taken into account by the free-hadron-gas (FHG) model with the volume-exclusion effect due to the hadron generation. The EPNJL+FHG model improves agreement of the EPNJL model with LQCD data particularly at small temperature. The quarkyonic phase survives, even if the correlation between the chiral condensate and the Polyakov loop is strong and hadron degrees of freedom are taken into account. However, the location of the quarkyonic phase is sensitive to the strength of the volume exclusion.Comment: 9 pages, 7 figure

The relationship between the size of caudolateral curvilinear osteophyte of the canine femoral neck and the radiographic view

Caudolateral curvilinear osteophyte (CCO), an osteophyte at the site of joint capsule attachment on the caudal aspect of the femoral neck, has been advocated as a radiographic criterion for coxofemoral subluxation. The correlation between the presence of CCO on radiographs (radiographic-CCO), the size of the CCO (CCO index) on three-dimensional computed tomographic (CT) images, and hip evaluation using transverse CT images was assessed in 22 Border Collies. CCOs were detected on the radiographs and CT images of 32% and 100% femurs, respectively. The CCO index correlated significantly with radiographic-CCO, but a large CCO index did not necessarily imply that the CCO was visible on radiographs. Hence, radiographic-CCO findings should be used cautiously in hip evaluation of Border Collies

MtDNA variation and human-mediated introgression of indigenous sus populations on several Indonesian Islands

o examine the genetic origin of the domestic pig, the distribution of wild boar, and　human-mediated translocation of the domestic pig, we collected 223 samples from domestic pigs and　wild boars from eight Indonesian islands, sequenced the control region of mitochondrial DNA　(mtDNA) from each sample, and compared these sequences with previously determined sequences from East and Southeast Asian domestic pigs and wild boars. Three Sus species (S. scrofa, S.verrucosus, and S. celebensis) were identified on the Indonesian islands. The mtDNA sequences of　three Indonesian Sus species were diverse, and they clustered into three lineages with low bootstrap　values (an S. scrofa group including East and Southeast Asian domestic pigs and wild boars, a group including indigenous S. scrofa together with S. verrucosus from Sumatra and Java Islands, and an S.celebensis group from Sulawesi Island). The mtDNA haplotypes of S. scrofa wild boars from three　(Sumbawa, Flores and New Guinea) islands and domestic pigs from two (Lombok and Timor) islands east of the Wallace Line, and some S. scrofa wild boars from Sumatra and Java Islands were related　to Vietnamese pig mtDNA sequences in the East and Southeast Asian domestic pig and wild boar　clade, supporting that ancient immigrants likely introduced domestic pigs from the Asian continent to east Indonesian islands. The mtDNA haplotypes of S. celebensis were broadly divided into three　groups, which were distributed in the north and southwest areas, central area and southeast area of　Sulawesi Island

Characterization of isotope effect on ion internal transport barrier and its parameter dependence in the Large Helical Device

In this paper, the background physics of the isotope effects in the ion internal transport barrier (ITB) are discussed in detail. An heuristic criterion for the ITB strength is defined based on the nonlinear dependence of the ion thermal diffusivity on the local ion temperature in the L-mode phase. Comparing deuterium plasmas and hydrogen plasmas, two isotope effects on the ion ITB are clarified: stronger ITBs formed in the deuterium plasmas and an ITB concomitant edge confinement degradation in the hydrogen plasmas. Principal component analysis reveals that the ion ITB becomes strong when a high input power normalized by the line averaged electron density is applied and electron density profile is peaked. A gyrokinetic simulation suggests that the ITB profile is determined by the ion temperature gradient driven turbulence, while the way the profile saturates in L-mode plasmas is unknown. In the electron density turbulence behavior, a branch transition is observed, where the increasing trend in turbulence amplitude against the ITB strength is flipped to a decreasing trend across the ITB formation. The radial electric field structure is measured by the charge exchange recombination spectroscopy system. It is found that the radial electric field shear plays a minor role in determining the ITB strength

Effects of time-compressed speech training on multiple functional and structural neural mechanisms involving the left superior temporal gyrus

Time-compressed speech is an artificial form of rapidly presented speech. Training with time-compressed speech (TCSSL) in a second language leads to adaptation toward TCSSL. Here, we newly investigated the effects of 4 weeks of training with TCSSL on diverse cognitive functions and neural systems using the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), resting-state functional connectivity (RSFC) with the left superior temporal gyrus (STG), fractional anisotropy (FA), and regional gray matter volume (rGMV) of young adults by magnetic resonance imaging. There were no significant differences in change of performance of measures of cognitive functions or second language skills after training with TCSSL compared with that of the active control group. However, compared with the active control group, training with TCSSL was associated with increased fALFF, RSFC, and FA and decreased rGMV involving areas in the left STG. These results lacked evidence of a far transfer effect of time-compressed speech training on a wide range of cognitive functions and second language skills in young adults. However, these results demonstrated effects of time-compressed speech training on gray and white matter structures as well as on resting-state intrinsic activity and connectivity involving the left STG, which plays a key role in listening comprehension

Effects of training of shadowing and reading aloud of second language on working memory and neural systems

Shadowing and reading aloud both involve multiple complex cognitive processes, and both are considered effective methods for second-language learning. The working memory system, particularly the phonological loop, has been suggested to be involved in shadowing and reading aloud. The purpose of this study was to investigate the effects of a 4-week intensive adaptive training including shadowing and reading aloud of second language on working-memory capacity, regional gray matter volume (rGMV), and functional activation related to the n-back working-memory task in young adults. The results showed that compared with the training groups without speaking (listening to compressed speech and active control involving the second language), the training groups with speaking (shadowing and reading aloud) showed a tendency for greater test-retest increases in digit-span scores, and significantly greater test-retest decreases in N-back task reaction time (increase in working memory performance). Imaging analyses revealed compared with the active control group, shadowing group exhibited decreases in rGMV and brain activity during the working memory task (2-back task), in the left cerebellum and reading group exhibited decreases in them in the right anterior insula. These regions are parts of the phonological loop, suggesting the presence of training-induced neural plasticity in these neurocognitive mechanisms