36 research outputs found
Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes
- Author
- Aaron Sarah T
- Bailey Celeste V
- Blumberg Andrew J
- Cheng Jeffrey B
- Chiotti Kami E
- Cho Raymond J
- Chung Jongsuk
- Cleaver James E
- Collison Eric A
- Costello Joseph F
- Cunningham Bati B
- Fassihi Hiva
- Fudem Gary M
- Gray Joe W
- Huh Nam
- Hur Joseph S
- LeBoit Philip E
- Lehmann Alan
- Liao Wilson
- Mihm Frederick G
- Moslehi Homayoun
- Naujokas Agne
- Neuhaus Isaac M
- Oh Dennis H
- Purdom Elizabeth
- Sanborn J Zachary
- Spellman Paul T
- Vemula Swapna S
- Wang Nicholas J
- Zheng Christina L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2014
- Field of study
SummarySomatic mutations in cancer are more frequent in heterochromatic and late-replicating regions of the genome. We report that regional disparities in mutation density are virtually abolished within transcriptionally silent genomic regions of cutaneous squamous cell carcinomas (cSCCs) arising in an XPC−/− background. XPC−/− cells lack global genome nucleotide excision repair (GG-NER), thus establishing differential access of DNA repair machinery within chromatin-rich regions of the genome as the primary cause for the regional disparity. Strikingly, we find that increasing levels of transcription reduce mutation prevalence on both strands of gene bodies embedded within H3K9me3-dense regions, and only to those levels observed in H3K9me3-sparse regions, also in an XPC-dependent manner. Therefore, transcription appears to reduce mutation prevalence specifically by relieving the constraints imposed by chromatin structure on DNA repair. We model this relationship among transcription, chromatin state, and DNA repair, revealing a new, personalized determinant of cancer risk
Broad versus narrow clinical practice guidelines: avoiding rules for the high risk 1
- Author
- Alam Murad
- Behshad Ramona
- Bolotin Diana
- Cartee Todd V
- Council M. Laurin
- Eisen Daniel B
- Golda Nicholas
- Harikumar Vishnu
- Huang Conway C
- Ibrahim Sarah A
- Ibrahim Sherrif F
- Jiang S. Brian
- Kang Bianca Y
- Kibbi Nour
- Lawrence Naomi
- Lee Erica H
- Leitenberger Justin J
- Maher Ian A
- Mann Margaret W
- Minkis Kira
- Nehal Kishwer S
- Neuhaus Isaac M
- Owen Joshua L
- Ozog David M
- Petersen Brian
- Reynolds Kelly A
- Samie Faramarz H
- Shin Thuzar M
- Sobanko Joseph F
- Somani Ally-Khan
- Stebbins William G
- Waldman Abigail H
- Worley Brandon
- Xu Y. Gloria
- Yu Siegrid S
- Zeitouni Nathalie C
- Publication venue
- Henry Ford Health System Scholarly Commons
- Publication date
- 11/11/2020
- Field of study
Principles for developing and adapting clinical practice guidelines and guidance for pandemics, wars, shortages, and other crises and emergencies: the PAGE criteria
- Author
- Alam Murad
- Behshad Ramona
- Bichakjian Christopher K
- Bolotin Diana
- Bordeaux Jeremy S
- Cartee Todd V
- Council M. Laurin
- Eisen Daniel B
- Golda Nicholas
- Harikumar Vishnu
- Huang Conway C
- Ibrahim Sarah A
- Ibrahim Sherrif F
- Jiang S. Brian
- Kang Bianca Y
- Kibbi Nour
- Lawrence Naomi
- Lee Erica H
- Leitenberger Justin J
- Maher Ian A
- Mann Margaret W
- Minkis Kira
- Nehal Kishwer S
- Neuhaus Isaac M
- Owen Joshua L
- Ozog David M
- Petersen Brian
- Reynolds Kelly A
- Samie Faramarz H
- Shin Thuzar M
- Sobanko Joseph F
- Somani Ally-Khan
- Stebbins William G
- Waldman Abigail H
- Wang Jordan V
- Worley Brandon
- Xu Y. Gloria
- Yu Siegrid S
- Zeitouni Nathalie C
- Publication venue
- Henry Ford Health System Scholarly Commons
- Publication date
- 18/11/2020
- Field of study
Development of international clinical practice guidelines: benefits, limitations, and alternative forms of international collaboration
- Author
- Alam Murad
- Behshad Ramona
- Bichakjian Christopher K
- Bolotin Diana
- Bordeaux Jeremy S
- Cartee Todd V
- Council M. Laurin
- Eisen Daniel B
- Golda Nicholas
- Harikumar Vishnu
- Huang Conway C
- Ibrahim Sarah A
- Ibrahim Sherrif F
- Jiang S. Brian
- Kang Bianca Y
- Kibbi Nour
- Lawrence Naomi
- Lee Erica H
- Leitenberger Justin J
- Maher Ian A
- Mann Margaret W
- Minkis Kira
- Nehal Kishwer S
- Neuhaus Isaac M
- Owen Joshua L
- Ozog David M
- Petersen Brian
- Reynolds Kelly A
- Samie Faramarz H
- Shin Thuzar M
- Sobanko Joseph F
- Somani Ally-Khan
- Stebbins William G
- Waldman Abigail H
- Wang Jordan V
- Worley Brandon
- Xu Y. Gloria
- Yu Siegrid S
- Zeitouni Nathalie C
- Publication venue
- Henry Ford Health System Scholarly Commons
- Publication date
- 20/11/2020
- Field of study
The Magnitude of Global Marine Species Diversity
- Author
- Ahyong Shane T.
- Anderson Gary
- Angel Martin V.
- Appeltans Ward
- Artois Tom
- Bailly Nicolas
- Bamber Roger
- Barber Anthony
- Bartsch Ilse
- Berta Annalisa
- Blazewicz-Paszkowycz Magdalena
- Bock Phil
- Boxshall Geoff
- Boyko Christopher B.
- Bray Rod A.
- Bruce Niel L.
- Cairns Stephen D.
- Chan Tin-Yam
- Cheng Lanna
- Collins Allen G.
- Costello Mark J.
- Cribb Thomas
- Curini-Galletti Marco
- Dahdouh-Guebas Farid
- Davie Peter J.F.
- Dawson Michael N.
- De Clerck Oivier
- De Grave Sammy
- de Voogd Nicole J.
- Decock Wim
- Domning Daryl P.
- Emig Christian C.
- Erséus Christer
- Eschmeyer William
- Fauchald Kristian
- Fautin Daphne G.
- Feist Stephen W.
- Fransen Charles H.J.M.
- Furuya Hidetaka
- Garcia-Alvarez Oscar
- Gerken Sarah
- Gibson David
- Gittenberger Arjan
- Gofas Serge
- Gordon Dennis P.
- Guiry Michael D.
- Gómez-Daglio Liza
- Hernandez Francisco
- Hoeksema Bert W.
- Hopcroft Russell R.
- Jaume Damià
- Kirk Paul
- Koedam Nico
- Koenemann Stefan
- Kolb Jürgen B.
- Kristensen Reinhardt M.
- Kroh Andreas
- Lambert Gretchen
- Lazarus David B.
- Lemaitre Rafael
- Longshaw Matt
- Lowry Jim
- Macpherson Enrique
- Madin Laurence P.
- Mah Christopher
- Mapstone Gill
- McLaughlin Patsy A.
- Mees Jan
- Meland Kenneth
- Messing Charles
- Mills Claudia E.
- Molodtsova Tina N.
- Mooi Rich
- Neuhaus Birger
- Ng Peter K.L.
- Nielsen Claus
- Norenburg Jon
- Nunes Brandão Simone
- Opresko Dennis M.
- Osawa Masayuki
- Paulay Gustav
- Perrin William
- Pilger John F.
- Poore Gary C.B.
- Pugh Phil
- Read Geoffrey B.
- Reimer James D.
- Rius Marc
- Rocha Rosana M.
- Saiz-Salinas José I.
- Scarabino Victor
- Schierwater Bernd
- Schmidt-Rhaesa Andreas
- Schnabel Kareen E.
- Schotte Marilyn
- Schuchert Peter
- Schwabe Enrico
- Segers Hendrik
- Self-Sullivan Caryn
- Shenkar Noa
- Siegel Volker
- Sterrer Wolfgang
- Stöhr Sabine
- Swalla Billie
- Tasker Mark L.
- Thuesen Erik V.
- Timm Tarmo
- Todaro M. Antonio
- Turon Xavier
- Tyler Seth
- Uetz Peter
- van der Land Jacob
- van Ofwegen Leen P.
- van Soest Rob W.M.
- Vanaverbeke Jan
- Vanhoorne Bart
- Walker-Smith Genefor
- Walter T. Chad
- Warren Alan
- Williams Gary C.
- Wilson Simon P.
- Publication venue
- NSUWorks
- Publication date
- 01/01/2012
- Field of study
Background: The question of how many marine species exist is important because it provides a metric for how much we do and do not know about life in the oceans. We have compiled the first register of the marine species of the world and used this baseline to estimate how many more species, partitioned among all major eukaryotic groups, may be discovered.
Results: There are ∼226,000 eukaryotic marine species described. More species were described in the past decade (∼20,000) than in any previous one. The number of authors describing new species has been increasing at a faster rate than the number of new species described in the past six decades. We report that there are ∼170,000 synonyms, that 58,000–72,000 species are collected but not yet described, and that 482,000–741,000 more species have yet to be sampled. Molecular methods may add tens of thousands of cryptic species. Thus, there may be 0.7–1.0 million marine species. Past rates of description of new species indicate there may be 0.5 ± 0.2 million marine species. On average 37% (median 31%) of species in over 100 recent field studies around the world might be new to science.
Conclusions: Currently, between one-third and two-thirds of marine species may be undescribed, and previous estimates of there being well over one million marine species appear highly unlikely. More species than ever before are being described annually by an increasing number of authors. If the current trend continues, most species will be discovered this century
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Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Aizenberg I
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FL Lucio
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andana RY Gonzalez
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda C Padilla
- Aranzabal N
- Araya S Tapia
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Austrup VA
- Avner G
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahilo JJ Lozano
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barends KN
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barron U
- Barrue RF Coelho
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Baselga M
- Bashta I
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley John
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Biebel O
- Bielski R
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjorke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blumenthal J
- Bobbink GJ
- Bobrovnikov VS
- Boehler M
- Boeriu OE Vickey
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bolanos G Rabanal
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbely AG
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Bosca S Rodriguez
- Boscherini D
- Bosman M
- Bostanabad M Ghasemi
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Bourdarios C Adam
- Boveia A
- Boyd J
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- Bozson AJ
- Bracinik J
- Brahimi N
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- Brandt Oleg
- Braren F
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- Brendlinger K
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- Bressler S
- Bret M Cano
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Bruers B
- Bruncko D
- Bruni A
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- Bruschi M
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- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Bugge MK
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr Jon
- Burton CD
- Burzynski JC
- Busch EL
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- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buzykaev AR
- Bylund O Bessidskaia
- Cabras G
- Caforio D
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- Cairo VMM
- Cakir I Turk
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- Calderini G
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- Caloba LP
- Calvet D
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- Camarri P
- Camelia E Alunno
- Camerlingo MT
- Cameron D
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- Canale V
- Canesse A
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- Capocasa F
- Capriles FG Diaz
- Capua M
- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carlson T Ingebretsen
- Carminati L
- Carnesale M
- Carney RMD
- Caron S
- Carquin E
- Carra S
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- Carter JWS
- Carter TM
- Casadei D
- Casado MP
- Casha AF
- Castiglia EG
- Castillo FL
- Castillo LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
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- Cavasinni V
- Celebi E
- Celli F
- Centonze MS
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chala M
- Chan J
- Chan WS
- Chan WY
- Chapman John
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen X
- Chen Y
- Chen Y-H
- Cheng CL
- Cheng HC
- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
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- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Cioara IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
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- Clark PJ
- Clawson SE
- Clement C
- Clissa L
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Codina E Perez
- Coelli S
- Cohen H
- Coimbra AEC
- Cole B
- Collaboration ATLAS
- Collot J
- Columbie JM Clavijo
- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cormier F
- Cornell S Diez
- Corpe LD
- Corradi M
- Correia AM Henriques
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Coutinho Y Amaral
- Cowan G
- Cowley JW
- Cranmer K
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosetti G
- Cueto A
- Cui H
- Cukierman AR
- Cunningham WR
- Curcio F
- Czodrowski P
- Czurylo MM
- D'amen G
- D'Amico V
- D'Auria S
- D'Eramo L
- D'onofrio A
- D'Onofrio M
- D'uffizi M
- Da Costa AM Mendes Jacques
- da Costa J Barreiro Guimaraes
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damazio D Oliveira
- Damp J
- Dandoy JR
- Daneri MF
- Danninger M
- Dao V
- Darbo G
- Darmora S
- Dattagupta A
- David C
- Davidek T
- Davis DR
- Davis-Purcell B
- Dawson I
- de Andrade Filho L Manhaes
- De Araujo M Verissimo
- De Asmundis R
- De Beurs M
- De Carvalho AL Moreira
- De Castro S
- De Groot N
- de Jong P
- de la Hoz S Gonzalez
- De la Torre H
- De Lima R Teixeira
- De Maria Ac
- De Pedis D
- de Renstrom PA Bruckman
- De Sa R Coelho Lopes
- De Salvo A
- De Sanctis U
- De Santis M
- De Santo A
- De Souza E Egidio Purcino
- De Vivie De Regie JB
- De K
- Dedovich DV
- Degens J
- Deiana AM
- Del Peso J
- Deliot F
- Delitzsch CM
- Dell'Acqua A
- Dell'Asta L
- Delmastro M
- Delsart PA
- Demers S
- Demichev M
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Dette K
- Deutsch C
- Deviveiros PO
- Di Bello FA
- Di Ciaccio L
- Di Ciaccioa A
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Luca A
- Di Nardo R
- Diaconu C
- Dias Do Vale T
- Dias FA
- Diaz L Pedraza
- Diaz MA
- Diaz Y Delabat
- Dickinson J
- Didenko M
- Diehl EB
- Dietrich J
- Dimitrievska A
- Ding W
- Dingfelder J
- Dinu I-M
- Dittmeier SJ
- Dittus F
- Djama F
- Djobava T
- Djuvsland JI
- Do Vale MAB
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Dominguez L Pascual
- Don M Madugoda Ralalage
- Donadelli M
- Donaldson C Pitman
- Dong B
- Donini J
- Donszelmann T Cuhadar
- Dopke J
- Doria A
- Dos Santos SP Amor
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac AS
- Du D
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Duflot L
- Duhrssen M
- Dulsen C
- Dumitriu AE
- Dunford M
- Dungs S
- Dunne K
- Duperrin A
- Duren M
- Durglishvili A
- Dutta B
- Dyckes GI
- Dyndal M
- Dysch S
- Dziedzic BS
- Eckerova B
- Eggleston MG
- Ehrke LF
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Moursli R Cherkaoui
- El Moussaouy A
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Emerman A
- Enari Y
- Erdmann J
- Ereditato A
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estabragh M Rezaei
- Estevez M Alvarez
- Etzion E
- Evans G
- Evans H
- Evans MO
- Ezhilov A
- Fabbri F
- Fabbri L
- Facini G
- Fadeyev V
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fan Y
- Fang Y
- Fanourakis G
- Fanti M
- Faraj M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrington SM
- Farthouat P
- Fassi F
- Fassouliotis D
- Fawcett William
- Fayard L
- Fedin OL
- Feickert M
- Felice ND
- Feligioni L
- Fell A
- Feng C
- Feng M
- Fenton MJ
- Fenyuk AB
- Ferguson SW
- Fernandez S Gonzalez
- Ferrando J
- Ferrari A
- Ferrari P
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- Yao W-M
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- Yexley MR
- Yildiz H Duran
- Yin P
- Yorita K
- Yoshihara K
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- Zagazeta LF Gutierrez
- Zaid E
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
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- Zanzi D
- Zeissner SV
- Zeitnitz C
- Zeng JC
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- Zerradi S
- Zerwas D
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- Zhang G
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- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhou H
- Zhou N
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- Zhu H
- Zhu HL
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- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zivkovic L
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 03/02/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a Zγ pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at s = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fb−1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of Zγ in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
- Author
- A. Appelt-Menzel
- A. Bach
- A. Cubukova
- Abdurashitov Arkady
- Agata Krawczynska
- Aleksandra Szczepkowska
- Alekseeva Anna
- Alena Michalicova
- Alexa Fries
- Alexander Reitner
- Alexandra Bocsik
- Alla B. Salmina
- Alon Friedman
- Alon Friedman
- Alwin Kamermans
- Ana C. Calpena
- Ana Maria Teixeira
- Ana Pombero
- Ana Raquel Santa Maria
- Ana Rita Bras
- Ana-Maria Pilbat
- Andrea Fuso
- Andrej Kovac
- Andrey V. Morgun
- Andrzej Malecki
- Andrzej Małecki
- Andrzej P. Herman
- András Dér
- András Harazin
- András Kincses
- Anika Hartz
- Anna Gerhartl
- Anna Huber
- Anna Schönegger
- Anne Iltzsche
- Arkadiusz Liskiewicz
- Armelle Klopstein
- Arzu Temizyürek
- Attila E. Farkas
- Birger Brodin
- Bodrova Madina
- Boytsova Elizaveta
- Bragin Denis
- Brigitta Dukay
- Britta Engelhardt
- Bucharskaya Alla
- Bülent Ahıshalı
- C. J. Czupalla
- Canan Uğur Yılmaz
- Candan Gürses
- Carsten Uhd Nielsen
- Catherine E Angel
- Cherubino Di Lorenzo
- Chih-Chieh Tsao
- Chris Greene
- Christina Christoffersen
- Christina Dilling
- Christina Simoglou Karali
- Claus U. Surma
- Colin P. Doherty
- Conor Delaney
- Csilla Fazakas
- Daisuke Watanabe
- Dan Milikovsky
- Dan T Kho
- Daniel A. Lawrence
- Daniel C. Anthony
- Daniela Kasprowska-Liśkiewicz
- David A. Antonetti
- David Bueno
- David Francisco
- David J Begley
- David M. F. Francisco
- David Male
- Dionna W. Williams
- Dmitri Sisario
- Dror Rosenbach
- Dóra Lipka
- E. Fidan
- E. Scott Graham
- Edith Filaire
- Edward A. Neuwelt
- Edyta Skonieczna
- Elena A. Pozhilenkova
- Elena D. Khilazheva
- Elizaveta B. Boytsova
- Emmanuel Sevin
- Enming Joe Su
- Eoin Kelly
- Eoin O’Keefe
- Eugene Wallace
- Fabien Gosselet
- Fang Niu
- Ferenc Fenyvesi
- Franco Laccone
- Fruzsina Walter
- Galina P. Martynova
- Gekalyuk Artem
- Gerald A. Grant
- Gergő Porkoláb
- Gijs Kooij
- Gizem Nur Şahin
- Guohua Xi
- Guy Bar-Klein
- H. Gerhardt
- H. Zieliński
- Hannes Steinkellner
- Hans Christian Helms
- Helga E de Vries
- Helga E. de Vries
- Helle Sønderby Waagepetersen
- Hong Ye
- Ignacio A. Romero
- Imola Wilhelm
- Inez Fręśko
- Isabelle Gruber
- István A. Krizbai
- J. Macas
- Jack van Horssen
- James F. Meaney
- Jamie Lim
- Janina Skipor
- Janina Skipor-Lahuta
- Jaroslav Galba
- Jennifer Pereira
- Jens Pahnke
- Jianming Xiang
- Joan W. Berman
- John Kealy
- John Kealy
- Jordi Garcia-Fernàndez
- Josephin Wagner
- Judit Váradi
- Judit Vígh
- Julia Baumann
- János Haskó
- K. Devraj
- K. H. Plate
- K. Strømgaard
- Karl Schoknecht
- Kathrin Hahn
- Kenta Ujifuku
- Khilazheva Elena
- Khorovodov Alexander
- Kinga G. Blecharz
- Kinga Molnár
- Krisztina Nagy
- Krzysztof Kucharz
- Krzysztof Milewski
- Kurths Jürgen
- Lars Bo Nielsen
- Lars Winkler
- Laurence Fenart
- Lester R. Drewes
- Lisa J. Routhe
- Luca Marchetti
- Lucia Celkova
- Luciele Guerra Minuzzi
- Luis Federico Batiz
- Lydia Gabbert
- Lyna Solomon-Kamintsky
- László Puskás
- Lívia Fülöp
- Lóránd Kiss
- M. Kristensen
- M. Metzger
- M. Surma
- Magdalena Zielińska
- Malgorzata Burek
- Malinovskaya Nataliya
- Manuel Sarmiento Soto
- Marcelle Silva de Abreu
- Maria A. Deli
- Maria Luisa García
- Marian M. Humphries
- Mariangela Corsi
- Marta Espina
- Marta Kowalewska
- Marta Martinez-Morga
- Marta Nowacka-Chmielewska
- Marta Obara-Michlewska
- Marta Przybyla
- Marta Skowronska
- Martin Lauritzen
- Matheus Uba Chupel
- Matthew Campbell
- Mehmet Kaya
- Melinda E. Tóth
- Melissa A. Lopes-Pinheiro
- Mette Mathiesen Janiurek
- Michael Farrell
- Michael G. Molloy
- Michal Novak
- Michal Toborek
- Michal Toborek
- Mihály Kozma
- Mike Veenstra
- Mikio Furuse
- Miklós Sántha
- Miklós Vecsernyés
- Minseon Park
- Morgun Andrey
- Mutlu Küçük
- Mária A. Deli
- Mária Mészáros
- Müge Atış
- N. Joan Abbott
- Nadir Arıcan
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- Navolokin Nikita
- Neli Bounzina
- Niall Pender
- Niamh Doyle
- Nicola R. Sibson
- Nicole Kachappilly
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- Nikolett Lénárt
- Niloufar Zarghami
- Nobutaka Horie
- Nurcan Orhan
- Ofer Prager
- Omolara O. Ogunshola
- Omolara Ogunshola
- Pavlov Valery
- Peter Vajkoczy
- Petra Majerova
- Pietra Candela
- Poyraz Düzgün
- Péter Galajda
- Péter Nagyőszi
- R. Fischer
- Ralph M. Garruto
- Raquel Garcia-Lopez
- Rebecca H Johnson
- Remy Bruggmann
- Richard F. Keep
- Richard Kovács
- Rita Businaro
- Romain Versele
- Ronel Veksler
- Rosiris Leon Rivera
- Rouhollah Khodadust
- Ruth Lyck
- Ruud Fontijn
- Rémy Bruggmann
- S. Guérit
- S. Liebner
- S. Thom
- Sabela Rodríguez-Lorenzo
- Sabrina Engelhardt
- Sagatova Artem
- Salmin Vladimir
- Salmina Alla
- Salvador Martinez
- Samar Osmen
- Sandra Mihaljevic
- Sarah Doyle
- Semyachkina-Glushkovskaya Oxana
- Serkan Emik
- Serçin Karahüseyinoğlu
- Shareef Ali Esmat
- Sheng-Fu Huang
- Shilpa Buch
- Shinsuke Nakagawa
- Shirokov Alexander
- Shushunova Anastasia
- Sidar Aydin
- Simon J O’Carroll
- Steffen Storck
- Stephanie Hughes
- Susan Morgello
- Svetlana Drndarski
- Szilvia Veszelka
- Sándor Valkai
- Takashi Fujimoto
- Takayuki Matsuo
- Takeo Anda
- Torben Moos
- Tsuyoshi Izumo
- Tuchin Artem
- Udi Vazana
- Ulanova Mariya
- Ulf Schneider
- Umut Deniz Ceylan
- Ursula Wyneken
- Uğur Akcan
- Victor Castro
- Vilmos Tubak
- Vinton Cheng
- Vladimir Soukhoroukov
- Vodovozova Elena
- Wendy W.J. Unger
- Winfried Neuhaus
- Ya Hua
- Yana V. Gorina
- Yang Yirong
- Yoichi Morofuji
- Yvonne Couch
- Z. Giżejewski
- Zsolt Bozsó
- Zsolt Radak
- Zsolt Török
- Zsófia Hoyk
- Ádám Nyúl-Tóth
- Ágnes Kittel
- Ágnes Zvara
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2017
- Field of study
https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd
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The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
- Aad G
- Abbott B
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 08/03/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
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- Zwalinski L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications
- Author
- Publication venue
- Elsevier
- Publication date
- 01/04/2024
- Field of study
Summary: Pathogenic variants in the DES gene clinically manifest as progressive skeletal muscle weakness, cardiomyopathy with associated severe arrhythmias, and respiratory insufficiency, and are collectively known as desminopathies. While most DES pathogenic variants act via a dominant mechanism, recessively acting variants have also been reported. Currently, there are no effective therapeutic interventions for desminopathies of any type. Here, we report an affected individual with rapidly progressive dilated cardiomyopathy, requiring heart transplantation at age 13 years, in the setting of childhood-onset skeletal muscle weakness. We identified biallelic DES variants (c.640-13 T>A and c.1288+1 G>A) and show aberrant DES gene splicing in the affected individual’s muscle. Through the generation of an inducible lentiviral system, we transdifferentiated fibroblast cultures derived from the affected individual into myoblasts and validated this system using RNA sequencing. We tested rationally designed, custom antisense oligonucleotides to screen for splice correction in these transdifferentiated cells and a functional minigene splicing assay. However, rather than correctly redirecting splicing, we found them to induce undesired exon skipping. Our results indicate that, while an individual precision-based molecular therapeutic approach to splice-altering pathogenic variants is promising, careful preclinical testing is imperative for each novel variant to test the feasibility of this type of approach for translation