Adverse events (n) reported during the observation, classified by CTCAE grade.

§<p>Acute hepatitis HBV,</p>*<p>Plus one case of: renal cancer, grade 3 rhabdomyolysis, non-Hodgkin’s lymphoma, coronary heart disease, diabetes, Basedow’s disease, portal hypertension, arterial hypertension, urinary tract infection, fever, acute psychosis, dizziness, flushing, macular rash of skin and glans, gout, cataract, dry skin, asymptomatic hyperuricemia and LDH increase.</p

Metabolic impact of raltegravir-based salvage salvage regimens over 96 weeks.

<p>In both figures values are presented as mean±standard deviation (SD). The dimension of the cohort at each timepoint is reported below (n.). (2A) AST and ALT slope over 96 weeks, all data caught (even 1 acute hepatitis B), (2B) total and fractionated cholesterol slope.</p

Main demographic features of the SALIR cohort (n = 320).

<p>SD  =  Standard Deviation, IDU  =  intravenous drug user, MSM =  male having sex with males, IQR  =  interquartile range, ARV  =  antiretroviral, ART =  antiretroviral therapy, HDL  =  high density lipoprotein, AST  =  aspartate aminotransferase, ALT  =  alanine aminotransferase.</p

Predictors of raltegravir effectiveness.

<p>ITT  =  intention-to-treat analysis, OT  =  on-treatment analysis, IDU  =  intravenous drug user; ARV  =  antiretroviral; ART  =  antiretroviral therapy; HCV  =  Hepatitis C Virus; HBV  =  Hepatitis B Virus.</p>*<p>only including selected variables (P<0.15).</p>§<p>P<0.05.</p

CD4+ T cells/mmc slope over 96 weeks and proportion of subjects achieving and maintaining optimal viral suppression, set for homogeneity at <50 copies/mL.

<p>The dimensions of the population at each timepoint is reported below (n). In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039222#pone-0039222-g001" target="_blank">figure 1A</a> values are presented as mean±standard deviation (SD). In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039222#pone-0039222-g001" target="_blank">figure 1B</a> the spotted line presents data in the on treatment analysis, while the continuous line shows the intention-to-treat, missing data  =  failure analysis (ITT; M = F).</p