Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury

IMPORTANCE: The relationship of prenatal diagnosis of critical congenital heart disease (CHD) with brain injury and brain development is unknown. Given limited improvement of CHD outcomes with prenatal diagnosis, the effect of prenatal diagnosis on brain health may reveal additional benefits. OBJECTIVE: To compare the prevalence of preoperative and postoperative brain injury and the trajectory of brain development in neonates with prenatal vs postnatal diagnosis of CHD. DESIGN, SETTING, AND PARTICIPANTS: Cohort study of term newborns with critical CHD recruited consecutively from 2001 to 2013 at the University of California, San Francisco and the University of British Columbia. Term newborns with critical CHD were studied with brain magnetic resonance imaging preoperatively and postoperatively to determine brain injury severity and microstructural brain development with diffusion tensor imaging by measuring fractional anisotropy and the apparent diffusion coefficient. Comparisons of magnetic resonance imaging findings and clinical variables were made between prenatal and postnatal diagnosis of critical CHD. A total of 153 patients with transposition of the great arteries and single ventricle physiology were included in this analysis. MAIN OUTCOMES AND MEASURES: The presence of brain injury on the preoperative brain magnetic resonance imaging and the trajectory of postnatal brain microstructural development. RESULTS: Among 153 patients (67% male), 96 had transposition of the great arteries and 57 had single ventricle physiology. The presence of brain injury was significantly higher in patients with postnatal diagnosis of critical CHD (41 of 86 [48%]) than in those with prenatal diagnosis (16 of 67 [24%]) (P = .003). Patients with prenatal diagnosis demonstrated faster brain development in white matter fractional anisotropy (rate of increase, 2.2%; 95% CI, 0.1%-4.2%; P = .04) and gray matter apparent diffusion coefficient (rate of decrease, 0.6%; 95%CI, 0.1%-1.2%; P = .02). Patients with prenatal diagnosis had lower birth weight (mean, 3184.5 g; 95%CI, 3050.3–3318.6) than those with postnatal diagnosis (mean, 3397.6 g; 95%CI, 3277.6–3517.6) (P = .02). Those with prenatal diagnosis had an earlier estimated gestational age at delivery (mean, 38.6 weeks; 95%CI, 38.2–38.9) than those with postnatal diagnosis (mean, 39.1 weeks; 95%CI, 38.8–39.5) (P = .03). CONCLUSIONS AND RELEVANCE: Newborns with prenatal diagnosis of single ventricle physiology and transposition of the great arteries demonstrate less preoperative brain injury and more robust microstructural brain development than those with postnatal diagnosis. These results are likely secondary to improved cardiovascular stability. The impact of these findings on neurodevelopmental outcomes warrants further study

Modelling the seasonal cycle of Uranus’s colour and magnitude, and comparison with Neptune

We present a quantitative analysis of the seasonal record of Uranus’s disc-averaged colour and photometric magnitude in Strömgren b and y filters (centred at 467 and 551 nm, respectively), recorded at the Lowell Observatory from 1950 to 2016, and supplemented with HST/WFC3 observations from 2016 to 2022. We find that the seasonal variations of magnitude can be explained by the lower abundance of methane at polar latitudes combined with a time-dependent increase of the reflectivity of the aerosol particles in layer near the methane condensation level at 1 – 2 bar. This increase in reflectivity is consistent with the addition of conservatively scattering particles to this layer, for which the modelled background haze particles are strongly absorbing at both blue and red wavelengths. We suggest that this additional component may come from a higher proportion of methane ice particles. We suggest that the increase in reflectivity of Uranus in both filters between the equinoxes in 1966 and 2007, noted by previous authors, might be related to Uranus’s distance from the Sun and the production rate of dark photochemical haze products. Finally, we find that although the visible colour of Uranus is less blue than Neptune, due to the increased aerosol thickness on Uranus, and this difference is greatest at Uranus’s solstices, it is much less significant than is commonly believed due to a long-standing misperception of Neptune’s ‘true’ colour. We describe how filter-imaging observations, such as those from Voyager-2/ISS and HST/WFC3, should be processed to yield accurate true colour representations

Advancing Health Equity in the US Military

Eliminating health disparities and achieving health equity are central to US national health objectives and the Military Health System’s “quadruple aim,” which has readiness as its core aim. Because military service members enjoy universal eligibility for health care, it is sometimes assumed that health disparities do not exist in the Department of Defense (DoD). However, while some studies have shown that disparities have been attenuated or eliminated in the DoD, others suggest that significant disparities remain. Reasons these disparities may remain include that universal eligibility for care does not necessarily result in equal to access to care, and that equal access to care does not necessarily result in health equity. Priority groups for DoD health equity research and advocacy efforts should include: racial and ethnic minorities, sexual and gender minorities, women, and enlisted ranks. The DoD can advance health equity by improving data quality, increasing relevant population health research, targeting interventions towards the social determinants of health, improving the health care experience, and integrating DoD health equity efforts with those in the US society at large

Latitudinal variations in methane abundance, aerosol opacity and aerosol scattering efficiency in Neptune's atmosphere determined from VLT/MUSE

Spectral observations of Neptune made in 2019 with the MUSE instrument at the Very Large Telescope in Chile have been analysed to determine the spatial variation of aerosol scattering properties and methane abundance in Neptune’s atmosphere. The darkening of the South Polar Wave (SPW) at ∼ 60◦S, and dark spots such as the Voyager 2 Great Dark Spot is concluded to be due to a spectrally-dependent darkening (λ < 650nm) of particles in a deep aerosol layer at ∼ 5 bar and presumed to be composed of a mixture of ~ 650 nm, with bright zones latitudinally separated by ∼ 25◦ . This feature, similar to the spectral characteristics of a discrete deep bright spot DBS-2019 found in our data, is found to be consistent with a brightening of the particles in the same ∼5-bar aerosol layer at λ > 650 nm. We find the properties of an overlying methane/haze aerosol layer at ∼ 2 bar are, to first-order, invariant with latitude, while variations in the opacity of an upper tropospheric haze layer reproduce the observed reflectivity at methane-absorbing wavelengths, with higher abundances found at the equator and also in a narrow ‘zone’ at 80◦S. Finally, we find the mean abundance of methane below its condensation level to be 6-7% at the equator reducing to ∼3% south of ∼25◦S, although the absolute abundances are model dependent

Latitudinal Variations in Methane Abundance, Aerosol Opacity and Aerosol Scattering Efficiency in Neptune's Atmosphere Determined From VLT/MUSE

Spectral observations of Neptune made in 2019 with the Multi Unit Spectroscopic Explorer (MUSE) instrument at the Very Large Telescope (VLT) in Chile have been analyzed to determine the spatial variation of aerosol scattering properties and methane abundance in Neptune's atmosphere. The darkening of the South Polar Wave at ∼60°S, and dark spots such as the Voyager 2 Great Dark Spot is concluded to be due to a spectrally dependent darkening (λ 650 nm. We find the properties of an overlying methane/haze aerosol layer at ∼2 bar are, to first-order, invariant with latitude, while variations in the opacity of an upper tropospheric haze layer reproduce the observed reflectivity at methane-absorbing wavelengths, with higher abundances found at the equator and also in a narrow “zone” at 80°S. Finally, we find the mean abundance of methane below its condensation level to be 6%–7% at the equator reducing to ∼3% south of ∼25°S, although the absolute abundances are model dependent.We are grateful to the United Kingdom Science and Technology Facilities Council for funding this research (Irwin: ST/S000461/1, Teanby: ST/R000980/1). Glenn Orton was supported by funding to the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). Leigh Fletcher and Mike Roman were supported by a European Research Council Consolidator Grant (under the European Union's Horizon 2020 research and innovation programme, grant agreement no. 723890) at the University of Leicester. Santiago Pérez-Hoyos and Agustin Sánchez-Lavega are supported by the Spanish project PID2019-109467GB-I00 (MINECO/FEDER, UE), Elkartek21/87 KK-2021/00061 and Grupos Gobierno Vasco IT-1742-22

2011 Wild Blueberry Project Reports

The 2011 edition of the Wild Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include: 1. Mechanisms through which wild blueberries affect functional characteristics of the arterial wall related to endothelial dysfunction in Spontaneously Hypertensive Rats 2. Do wild blueberries affect high blood lipids, high blood glucose and obesity as related to the Metabolic Syndrome? 3. Control tactics for blueberry pest insects, 2011 4. IPM strategies, 2011 5. Biology and ecology of pest insects, 2011 6. Biology and ecology of beneficial insects, 2011 7. Pesticide residues on lowbush blueberry, 2011 8. Maine wild blueberry –mummy berry research and extension 9. Valdensinia leaf spot – Education, control and research – 2011 10. Effect of soil pH on nutrient uptake 11. Evaluation of several growth regulators for stimulating lowbush blueberry rhizome production 12. Evaluation of the effects of Gypsum (CaSO4) on wild blueberry fruit Ca concentration 13. Fall application of tribenuron methyl for bunchberry control in wild blueberries, 2009-2011 – effects of fall versus spring pruning on cover and yield in the crop year (final report) 14. Wild Blueberry Extension Education Program in 2011 INPUT SYSTEMS STUDY: 15. Systems approach to improving the sustainability of wild blueberry production, Year 2 of a four-year study – experimental design 16. The effects of different agronomic practices on the composition and quality of wild blueberries 17. Systems approach to improving the sustainability of wild blueberry production, Year 2 of a four-year study, blueberry quality from the first harvest year 18. Food safety- Prevalence study of Escherichia coli O157:H7, Listeria monocytogenes and Salmonella spp. on lowbush blueberries (Vaccinium angustifolium) 19. Abundance of insect pest species and natural enemies in lowbush blueberry fields maintained under different management practices 20. Systems approach to improving the sustainability of wild blueberry production, Year 2 of a four-year study, disease management results 21. Systems approach to improving the sustainability of wild blueberry production, Year 2 of a four-year study, weed management results 22. Systems approach to improving sustainability of wild blueberry production, Year 1 of a four-year study, preliminary soil health and chemistry results 23. Management effects on the phosphorus chemistry of wild blueberry barrens soil 24. Systems approach to improving the sustainability of wild blueberry production, preliminary economic comparison 2010-2011 25. Transition to organic production Year 2: Evaluation of gypsum and bone char 26. The effect of field management, forest edge composition, and field location on insect-mediated ecosystem services (scavenging/predation) (ancillary study) 27. Pre-emergent combinations of herbicides for weed control in wild blueberry fields (ancillary study) 28. Systems approach to improving the sustainability of wild blueberry production – Ancillary land-leveling study, year 1 (ancillary study) 29. Effects of compost and mulch on soil health and soil nutrient dynamics in wild blueberry (ancillary study

The Ninth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Baryon Oscillation Spectroscopic Survey

The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median z=0.52), 102,100 new quasar spectra (median z=2.32), and 90,897 new stellar spectra, along with the data presented in previous data releases. These spectra were obtained with the new BOSS spectrograph and were taken between 2009 December and 2011 July. In addition, the stellar parameters pipeline, which determines radial velocities, surface temperatures, surface gravities, and metallicities of stars, has been updated and refined with improvements in temperature estimates for stars with T_eff<5000 K and in metallicity estimates for stars with [Fe/H]>-0.5. DR9 includes new stellar parameters for all stars presented in DR8, including stars from SDSS-I and II, as well as those observed as part of the SDSS-III Sloan Extension for Galactic Understanding and Exploration-2 (SEGUE-2). The astrometry error introduced in the DR8 imaging catalogs has been corrected in the DR9 data products. The next data release for SDSS-III will be in Summer 2013, which will present the first data from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) along with another year of data from BOSS, followed by the final SDSS-III data release in December 2014.Comment: 9 figures; 2 tables. Submitted to ApJS. DR9 is available at http://www.sdss3.org/dr

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Measurement of the Strong Coupling Constant from Inclusive Jet Production at the Tevatron pˉp\bar pp Collider

We report a measurement of the strong coupling constant, $\alpha_s(M_Z)$, extracted from inclusive jet production in $p\bar{p}$ collisions at $\sqrt{s}=$1800 GeV. The QCD prediction for the evolution of $\alpha_s$ with jet transverse energy $E_T$ is tested over the range 40<$E_T$<450 GeV using $E_T$ for the renormalization scale. The data show good agreement with QCD in the region below 250 GeV. In the text we discuss the data-theory comparison in the region from 250 to 450 GeV. The value of $\alpha_s$ at the mass of the $Z^0$ boson averaged over the range 40<$E_T$<250 GeV is found to be $\alpha_s(M_{Z})= 0.1178 \pm 0.0001{(\rm stat)}^{+0.0081}_{-0.0095}{\rm (exp. syst)}$. The associated theoretical uncertainties are mainly due to the choice of renormalization scale (^{+6%}_{-4%}) and input parton distribution functions (5%).Comment: 7 pages, 3 figures, using RevTeX. Submitted to Physical Review Letter