Comportamiento de los tumores malignos de tiroides en nuestro medio

Carcinoma is the most frequent thyroid gland tumor and also the most frequent endocrine system malignancy. Thyroid cancer affects women more frequently than men, usually having an onset between ages 25 and 65 years. A study was performed including all cases with thyroid malignancy surgically treated in the Provincial University Hospital Arnaldo Milian Castro between January and December 2003. The incidence was 34.3%, with a female gender preference, with a peak at ages between 31 and 60 years. The main clinical symptom was cervical mass. Preoperatory ancillary tests were performed in order to help diagnosis and therapy (hemogram, cervical ultrasound and fine needle aspiration biopsy), being the last two procedures of utmost importance regarding the practical management. The treatment was surgical in all cases, with a total thyroidectomy in 75% of them. The 75% of cases were discharged successfully, with a hospitalization of less than 3 days.El carcinoma es el cáncer más frecuente de las tumoraciones de la glándula tiroides y la neoplasia maligna más común del sistema endocrino. El cáncer tiroideo afecta a la mujer con mayor frecuencia que al hombre y suele presentarse en personas de 25-65 años de edad. Se estudiaron los pacientes intervenidos quirúrgicamente por tumores malignos de la glándula tiroides en el Hospital Universitario “Arnaldo Milián Castro” de Santa Clara en el período de un año (enero–diciembre de 2003). La incidencia fue de un 34.3%, con predominio del sexo femenino en relación al masculino y mayor incidencia en las edades comprendidas entre 31 y 60 años. La manifestación clínica fundamental fue el aumento de volumen a nivel cervical. Se realizaron estudios preoperatorios de importancia marcada para el diagnóstico y el tratamiento: hemograma, leucograma, ultrasonido cervical y biopsia por aspiración con aguja fina, los dos últimos son muy necesarios para definir la conducta a seguir. El tratamiento en todos los pacientes fue quirúrgico, en el 75% de los casos se practicó la tiroidectomía total, con resultados favorables. El 75% de los pacientes fueron egresados satisfactoriamente, con una estadía hospitalaria inferior a tres días

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population