A MegaCam Survey of Outer Halo Satellites. VII. A Single S\'ersic Index v/s Effective Radius Relation for Milky Way Outer Halo Satellites

In this work we use structural properties of Milky Way's outer halo ($R_G > 25\,\mathrm{kpc}$) satellites (dwarf spheroidal galaxies, ultra-faint dwarf galaxies and globular clusters) derived from deep, wide-field and homogeneous data, to present evidence of a correlation in the S\'ersic index v/s effective radius plane followed by a large fraction of outer halo globular clusters and satellite dwarf galaxies. We show that this correlation can be entirely reproduced by fitting empirical relations in the central surface brightness v/s absolute magnitude and S\'ersic index v/s absolute magnitude parameter spaces, and by assuming the existence of two types of outer halo globular clusters: one of high surface brightness (HSB group), with properties similar to inner halo clusters; and another of low surface brightness (LSB group), which share characteristics with dwarf spheroidal and ultra-faint dwarf galaxies. Given the similarities of LSB clusters with dwarf spheroidal and ultra-faint dwarf galaxies, we discuss the possibility that outer halo clusters also originated inside dark matter halos and that tidal forces from different galaxy host's potentials are responsible for the different properties between HSB and LSB clusters.Comment: 20 pages, 9 figures, 3 table

A MegaCam Survey of Outer Halo Satellites. VI: The Spatially Resolved Star Formation History of the Carina Dwarf Spheroidal Galaxy

We present the spatially resolved star formation history (SFH) of the Carina dwarf spheroidal galaxy, obtained from deep, wide-field g,r imaging and a metallicity distribution from the literature. Our photometry covers $\sim2$ deg$^2$, reaching up to $\sim10$ times the half-light radius of Carina with a completeness higher than $50\%$ at $g\sim24.5$, more than one magnitude fainter than the oldest turnoff. This is the first time a combination of depth and coverage of this quality has been used to derive the SFH of Carina, enabling us to trace its different populations with unprecedented accuracy. We find that Carina's SFH consists of two episodes well separated by a star formation temporal gap. These episodes occurred at old ($>10$ Gyr) and intermediate ($2$-$8$ Gyr) ages. Our measurements show that the old episode comprises the majority of the population, accounting for $54\pm5\%$ of the stellar mass within $1.3$ times the King tidal radius, while the total stellar mass derived for Carina is $1.60\pm0.09\times 10^{6} M_{\rm{\odot}}$, and the stellar mass-to-light ratio $1.8\pm0.2$. The SFH derived is consistent with no recent star formation which hints that the observed blue plume is due to blue stragglers. We conclude that the SFH of Carina evolved independently of the tidal field of the Milky Way, since the frequency and duration of its star formation events do not correlate with its orbital parameters. This result is supported by the age/metallicity relation observed in Carina, and the gradients calculated indicating that outer regions are older and more metal poor.Comment: Accepted in ApJ (22 pages, 13 figures

The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection

Aged garlic extract (AGE) is an odorless garlic preparation containing S-allylcysteine (SAC) as its most abundant compound. A large number of studies have demonstrated the antioxidant activity of AGE and SAC in both in vivo—in diverse experimental animal models associated to oxidative stress—and in vitro conditions—using several methods to scavenge reactive oxygen species or to induce oxidative damage. Derived from these experiments, the protective effects of AGE and SAC have been associated with the prevention or amelioration of oxidative stress. In this work, we reviewed different antioxidant mechanisms (scavenging of free radicals and prooxidant species, induction of antioxidant enzymes, activation of Nrf2 factor, inhibition of prooxidant enzymes, and chelating effects) involved in the protective actions of AGE and SAC, thereby emphasizing their potential use as therapeutic agents. In addition, we highlight the ability of SAC to activate Nrf2 factor—a master regulator of the cellular redox state. Here, we include original data showing the ability of SAC to activate Nrf2 factor in cerebral cortex. Therefore, we conclude that the therapeutic properties of these molecules comprise cellular and molecular mechanisms at different levels

The spatio-temporal distribution patterns of biting midges of the genus Culicoides in Salta Province, Argentina

The goal of this survey was to analyze the spatio-temporal distribution patterns of Culicoides Latreille species (Diptera: Ceratopogonidae) and their relationship with environmental variables in Salta, northwestern Argentina. Culicoides were collected monthly from January 2003 through December 2005. The influence of the climatic variables on population abundance was analyzed with a multilevel Poisson regression. A total of 918 specimens belonging to five species were collected. The most abundant species was Culicoides paraensis Goeldi (65.5%), followed by Culicoides lahillei Iches (14.6%) and Culicoides debilipalpis Lutz (7.6%). The highest seasonal abundance for C. paraensis, C. debilipalpis and C. lahillei occurred during the spring and summer. A Poisson regression analysis showed that the mean maximum and minimum temperature and the mean maximum and minimum humidity were the variables with the greatest influence on the population abundance of Culicoides species.Facultad de Ciencias Naturales y Muse

A MegaCam Survey of Outer Halo Satellites. I. Description of the Survey

We describe a deep, systematic imaging study of satellites in the outer halo of the Milky Way. Our sample consists of 58 stellar overdensities --- i.e., substructures classified as either globular clusters, classical dwarf galaxies, or ultra-faint dwarf galaxies --- that are located at Galactocentric distances of R$_{\rm GC}$ > 25 kpc (outer halo) and out to ~400 kpc. This includes 44 objects for which we have acquired deep, wide-field, $g-$ and $r-$band imaging with the MegaCam mosaic cameras on the 3.6m Canada-France-Hawaii Telescope and the 6.5m Magellan-Clay telescope. These data are supplemented by archival imaging, or published $gr$ photometry, for an additional 14 objects, most of which were discovered recently in the Dark Energy Survey (DES). We describe the scientific motivation for our survey, including sample selection, observing strategy, data reduction pipeline, calibration procedures, and the depth and precision of the photometry. The typical 5$\sigma$ point-source limiting magnitudes for our MegaCam imaging --- which collectively covers an area of ~52 deg$^{2}$ --- are $g_{\rm lim}$ ~25.6 and $r_{\rm lim}$ ~25.3 AB mag. These limits are comparable to those from the coadded DES images and are roughly a half-magnitude deeper than will be reached in a single visit with LSST. Our photometric catalog thus provides the deepest and most uniform photometric database of Milky Way satellites available for the foreseeable future. In other papers in this series, we have used these data to explore the blue straggler populations in these objects, their density distributions, star formation histories, scaling relations and possible foreground structures.Comment: Accepted for publication in Ap

New 9-Terpenyl(7-Terpenyl)Purines: synthesis and cytotoxicity

The purine ring system is one of the most widely distributed N-heterocycles in Nature [1] and many structurally modified purine nucleosides and nucleotides have activities ranging from antineoplastic and antiviral to antihypertensive, antiasthmatic, antituberculosis, etc [2]. Among the purine derivatives, we have put our attention on natural N-alkylpurines such as the asmarines or agelasimines, a group of secondary metabolites isolated from marine sponges with very interesting biological properties [3]. They have a diterpenoid moiety attached to the N-7 nitrogen atom of an adenine and are usually isolated in very small quantities, which limited their structure-activity relationship studies. Our research group has been involved for years in the design, synthesis and biological evaluation of cytotoxic compounds related to natural products, including the chemoinduction of bioactivity on inactive terpenoids [4]. These diterpenoid include compounds such as communic or cupressic acids that bear decaline moieties very close to those present in the above-mentioned marine natural products. These facts prompted us to design and prepare new terpenylpurine derivatives starting from natural monoterpenoids and diterpenoids, commercially available or isolated from their natural sources and transformed into appropriate alkylated agents. Thus, we have prepared purines alkylated at N-7 and N-9 positions with isoprenoids, monoterpenoids and diterpenoids, using two different synthetic approaches: from 6-chloropurine or from 4,5-diamine-6-chloropyrimidine. The structure of the synthesized purines are shown in the following figure. The purine analogues synthesized have been evaluated for their cytotoxicity against four tumour human cell lines (breast, non-small lung, cervical and hepatocellular carcinoma) and non-tumour cells (porcine liver primary cells). The most cytotoxic derivatives were those with a diterpenoid rest on the purine. The results obtained allowed to draw conclusions on the structure-activity relationship of the compounds in order to evaluate the influence of the terpenyl size on their cytotoxic properties

Jitter Tolerance Acceleration Using the Golden Section Optimization Technique

Post-silicon validation of high-speed input/output (HSIO) links is a critical process for product qualification schedules of computer platforms under the current time-to-market (TTM) commitments. The goal of post-silicon validation for HSIO links is to confirm design robustness of both receiver (Rx) and transmitter (Tx) circuitry in a real application environment. One of the most common ways to evaluate the performance of a HSIO link is to characterize the Rx jitter tolerance (JTOL) performance by measuring the bit error rate (BER) through the link under worst stressing conditions. However, JTOL testing is very time-consuming when executing at specification BER, and the testing time is extremely increased when considering manufacturing process, voltage, and temperature (PVT) test coverage for a qualification decision. In order to speed up this process, we propose a new approach for JTOL testing based on the golden section algorithm. The proposed method takes advantage of the fast execution of the golden section search with a high BER, while overcoming the lack of correlation between different BERs by performing a downward linear search at the actual target BER until no errors are seen. Our proposed methodology is validated by implementing it in a server HSIO link