29 research outputs found
Optimal focusing conditions for bright SPDC sources
Optimizing the brightness of a spontaneous parametric down conversion (SPDC)
source is an important task for many quantum information applications. We
investigate the optimal focusing conditions to maximize the number of photons
produced in an SPDC process and coupled with single mode fibers. We provide a
general expression for the two-photon wavefunction, generalizing previous known
results, by considering collinear and non-collinear emission. We present
analytical expressions for our results in the thin crystal limit and clarify
the relation between different focusing conditions already existing in the
literature. Differently to what previously reported, we show that the optimal
ratio between the pump waist and the generated photons waist depends on the
emission angle: it is for collinear degenerate emission and
approaches for larger collection angles. The role of spectral filters is
also analyzed. We support and enrich our discussion with numerical simulations,
performed for Type I SPDC in a BBO crystal. For this type of emission, we also
investigate the role of the transverse walk-off outside the thin crystal
regime.Comment: 13 pages, 7 figure
Optical interferometry in the presence of large phase diffusion
Phase diffusion represents a crucial obstacle towards the implementation of
high precision interferometric measurements and phase shift based communication
channels. Here we present a nearly optimal interferometric scheme based on
homodyne detection and coherent signals for the detection of a phase shift in
the presence of large phase diffusion. In our scheme the ultimate bound to
interferometric sensitivity is achieved already for a small number of
measurements, of the order of hundreds, without using nonclassical light
Towards Quantum Communication from Global Navigation Satellite System
Satellite-based quantum communication is an invaluable resource for the
realization of a quantum network at the global scale. In this regard, the use
of satellites well beyond the low Earth orbits gives the advantage of long
communication time with a ground station. However, high-orbit satellites pose a
great technological challenge due to the high diffraction losses of the optical
channel, and the experimental investigation of such quantum channels is still
lacking. Here, we report on the first experimental exchange of single photons
from Global Navigation Satellite System at a slant distance of 20000
kilometers, by exploiting the retroreflector array mounted on GLONASS
satellites. We also observed the predicted temporal spread of the reflected
pulses due to the geometrical shape of array. Finally, we estimated the
requirements needed for an active source on a satellite, aiming towards quantum
communication from GNSS with state-of-the-art technology.Comment: Revte
Gallium Arsenide (GaAs) Quantum Photonic Waveguide Circuits
Integrated quantum photonics is a promising approach for future practical and
large-scale quantum information processing technologies, with the prospect of
on-chip generation, manipulation and measurement of complex quantum states of
light. The gallium arsenide (GaAs) material system is a promising technology
platform, and has already successfully demonstrated key components including
waveguide integrated single-photon sources and integrated single-photon
detectors. However, quantum circuits capable of manipulating quantum states of
light have so far not been investigated in this material system. Here, we
report GaAs photonic circuits for the manipulation of single-photon and
two-photon states. Two-photon quantum interference with a visibility of 94.9
+/- 1.3% was observed in GaAs directional couplers. Classical and quantum
interference fringes with visibilities of 98.6 +/- 1.3% and 84.4 +/- 1.5%
respectively were demonstrated in Mach-Zehnder interferometers exploiting the
electro-optic Pockels effect. This work paves the way for a fully integrated
quantum technology platform based on the GaAs material system.Comment: 10 pages, 4 figure
The Lack of Systemic and Subclinical Side Effects of Botulinum Neurotoxin Type-A in Patients Affected by Post-Stroke Spasticity: A Longitudinal Cohort Study
Botulinum Neurotoxin type-A (BoNT-A) is the treatment of choice for focal post-stroke spasticity (PSS). Due to its mechanism of action and the administration method, some authors raised concern about its possible systemic diffusion leading to contralateral muscle weakness and autonomic nervous system (ANS) alterations. Stroke itself is a cause of motor disability and ANS impairment; therefore, it is mandatory to prevent any source of additional loss of strength and adjunctive ANS disturbance. We enrolled 15 hemiparetic stroke survivors affected by PSS already addressed to BoNT-A treatment. Contralateral handgrip strength and ANS parameters, such as heart rate variability, impedance cardiography values, and respiratory sinus arrythmia, were measured 24 h before (T0) and 10 days after (T1) the ultrasound (US)-guided BoNT-A injection. At T1, neither strength loss nor modification of the basal ANS patterns were found. These findings support recent literature about the safety profile of BoNT-A, endorsing the importance of the US guide for a precise targeting and the sparing of "critical" structures as vessels and nerves
Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease
The failure of several Phase II/III clinical trials in Alzheimer's disease (AD) with drugs targeting \u3b2-amyloid accumulation in the brain fuelled an increasing interest in alternative treatments against tau pathology, including approaches targeting tau phosphatases/kinases, active and passive immunization, and anti-tau aggregation. The most advanced tau aggregation inhibitor (TAI) is methylthioninium (MT), a drug existing in equilibrium between a reduced (leuco-methylthioninium) and oxidized form (MT+). MT chloride (methylene blue) was investigated in a 24-week Phase II clinical trial in 321 patients with mild to moderate AD that failed to show significant positive effects in mild AD patients, although long-term observations (50 weeks) and biomarker studies suggested possible benefit. The dose of 138 mg/day showed potential benefits on cognitive performance of moderately affected AD patients and cerebral blood flow in mildly affected patients. Further clinical evidence will come from the large ongoing Phase III trials for the treatment of AD and the behavioral variant of frontotemporal dementia on a new form of this TAI, more bioavailable and less toxic at higher doses, called TRx0237. More recently, inhibitors of tau acetylation are being actively pursued based on impressive results in animal studies obtained by salsalate, a clinically used derivative of salicylic acid
A Homodyne Detector Integrated onto a Photonic Chip for Measuring Quantum States and Generating Random Numbers
Data output from experiment and theory sub projects around quantum enhanced sensors. Using quantum states of light to enhance optical measurement precision and accuracy
Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition
Advancing age is the focus of recent studies on familial and sporadic Alzheimer's disease (AD), suggesting a prolonged pre-clinical phase several decades before the onset of dementia symptoms. Influencing some age-related conditions, such as frailty, may have an impact on the prevention of late-life cognitive disorders. Frailty reflects a nonspecific state of vulnerability and a multi-system physiological change with increased risk for adverse health outcomes in older age. In this systematic review, frailty indexes based on a deficit accumulation model were associated with late life cognitive impairment and decline, incident dementia, and AD. Physical frailty constructs were associated with late-life cognitive impairment and decline, incident AD and mild cognitive impairment, vascular dementia, non-AD dementias, and AD pathology in older persons with and without dementia, thus also proposing cognitive frailty as a new clinical condition with co-existing physical frailty and cognitive impairment in non-demented older subjects. Considering both physical frailty and cognitive impairment as a single complex phenotype may be central in the prevention of dementia and its subtypes with secondary preventive trials on cognitive frail older subjects. The mechanisms underlying the cognitive-frailty link are multi-factorial, and vascular, inflammatory, nutritional, and metabolic influences may be of major relevance. There is a critical need for randomized controlled trials of intervention investigating the role of nutrition and/or physical exercise on cognitive frail subjects with the progression to dementia as primary outcome. These preventive trials and larger longitudinal population-based studies targeting cognitive outcomes could be useful in further understanding the cognitive-frailty interplay in older age
Triceps Surae Muscle Characteristics in Spastic Hemiparetic Stroke Survivors Treated with Botulinum Toxin Type A: Clinical Implications from Ultrasonographic Evaluation
Equinovarus foot is one of the most commonly spasticity related conditions in stroke survivors, leading to an impaired gait and poor functional performances. Notably, spastic muscles undergo a dynamic evolution following typical pathophysiological patterns. Botulinum Neurotoxin Type A (BoNT-A) is the gold standard for focal spasticity treatment, and ultrasound (US) imaging is widely recommended to guide injections and monitor muscle evolution. The role of BoNT-A in influencing muscle fibroadipose degeneration is still unclear. In this study, we analyzed medial gastrocnemius (MG) and soleus (SOL) US characteristics (cross-sectional area, muscle thickness, pennation angle, and mean echo intensity) in 53 patients. MG and SOL alterations, compared to the unaffected side, depend on the spasticity only and not on the BoNT-A treatment. In functionally preserved patients (functional ambulation classification, FAC > 3; modified Ashworth scale, MAS ≤ 2), the ultrasonographic changes of MG compared to ipsilateral SOL observed in the paretic limb alone seems to be due to histological, anatomical, pathophysiological, and biomechanical differences between the two muscles. In subjects with poor walking capability and more severe spasticity, such ipsilateral difference was found in both calves. In conclusion, BoNT-A does not seem to influence muscle degeneration. Similar muscles undergo different evolution depending on the grade of walking deficit and spasticity