6 research outputs found

    Making a Case for Engaging Adolescents in Program Decision-Making

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    The study discussed here examined the degree to which adolescents believe they are involved in community decision-making and examined discrepancies between adult and adolescent perceptions of common youth problems. Perceptual data were compared to adolescents\u27 self-reported behavioral data to determine if perceptions diverge from reports of actual behaviors. Results indicate that many adolescents do not believe that their thoughts are considered valuable by decision-makers. However, differences in perceptions among adults and youth suggest that adolescent perceptions should be considered. Specifically, adults were particularly aware of adolescent behaviors with observable consequences, but adolescents were more aware of internal psychological problems

    Research Data of the 2014 Census of Open Access Repositories in Germany, Austria and Switzerland

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    <p>The "2014 Census of Open Access Repositories in Germany, Austria and Switzerland” (2014 Census) is a study on the green open access landscape conducted in the course of a project seminar at the Berlin School of Library and Information Science (BSLIS) at Humboldt-Universität zu Berlin. The 2014 Census not only succeeds the "2012 Census of Open Access Repositories in Germany"[1] but enhances it by adding an online survey to the qualitative analysis of the open access repository websites and the automatic validation of its metadata. Like in 2012 the 2014 Census gives insights into the development of open access repositories and current trends in repository design being of substantial use to open access repository operators.</p> <p>This 2014 Census data set represents the data collected in three different ways:</p> <ul> <li>qualitative analysis of the open access repository websites</li> <li>automatic validation of the metadata via OAI-PMH using the DINI-Validator [2] </li> <li>online survey of repository operators</li> </ul> <p>As in 2012 [3] the data set is provided in XLSX as well as in CSV format. The columns represent the criteria and the rows represent the analyzed open access repositories. In the XLSX file the header row gives the definition of each criterion in English and German. In the CSV "content" file the header row is in English short terms. The respective English and German definition can be found in the CSV "readme" file.</p> <p> </p> <p>[1] Vierkant, P. (2013). 2012 Census of Open Access Repositories in Germany: Turning Perceived Knowledge Into Sound Understanding. <em>D-Lib Magazine</em>, 19. http://dx.doi.org/10.1045/november2013-vierkant </p> <p>[2] http://oanet.cms.hu-berlin.de/validator/pages/validation_dini.xhtml</p> <p>[3] Vierkant, Paul; Voigt, Michaela; Dupski, Jens; David, Sammy; Lösch, Mathias (2013): 2012 Census of Open Access Repositories in Germany. fig<strong>share</strong>. <br> http://dx.doi.org/10.6084/m9.figshare.677099</p

    Metabolic characteristics of CD8<sup>+</sup> T cell subsets in young and aged individuals are not predictive of functionality

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    Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of antigen-experienced memory T (TMEM) cells, facilitating rapid functionality and survival. Given the semi-differentiated state of TVM cells and their altered functionality with age, here we investigate TVM cell metabolism and its association with longevity and functionality. Elevated SRC is a feature of TVM, but not TMEM, cells and it increases with age in both subsets. The elevated SRC observed in aged mouse TVM cells and human CD8+ T cells from older individuals is associated with a heightened sensitivity to IL-15. We conclude that elevated SRC is a feature of TVM, but not TMEM, cells, is driven by physiological levels of IL-15, and is not indicative of enhanced functionality in CD8+ T cells

    Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug delivery

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