Relaci?n entre el modelo pedag?gico social constructivista, y las pr?cticas pedag?gicas de los docentes de la instituci?n educativa INEM Manuel Murillo Toro de la ciudad de Ibagu?

202 p. Recurso Electr?nicoLa presente investigaci?n tuvo como objetivo establecer las caracter?sticas del modelo social constructivista que se evidencia en las pr?cticas pedag?gicas de los docentes de la instituci?n educativa INEM Manuel Murillo Toro de la ciudad de Ibagu?; para ello, se emple? una metodolog?a de tipo mixto (cualitativo y cuantitativo), mediante la aplicaci?n de diferentes instrumentos que incluyeron, encuestas a docentes y directivos de la instituci?n, el an?lisis documental, as? como la observaci?n directa a las clases de algunos docentes . Dentro de los resultados obtenidos se puede evidenciar que existe un nivel de incoherencia entre los planteamientos institucionales y las pr?cticas de ense?anza y aprendizaje que llevan a cabo los docentes. As? mismo, se recomienda a la instituci?n dise?ar estrategias con las cuales se logre una mayor apropiaci?n del modelo pedag?gico; esto, mediante un seguimiento constante y pertinente a los procesos que permiten la materializaci?n de sus componentes.The objective of this research was to establish the characteristics of the constructivist social model that is evident in the pedagogical practices of the teachers of the educational institution I NEM Manuel Murillo Toro of the city of Ibagu?; To this end, a mixed-type methodology (qualitative and quantitative) was used, by means of the application of different instruments that included, surveys to teachers and managers of the institution, the documentary analysis, as well as the direct observation to the classes of some teachers. Among the results obtained, it can be seen that there is a level of incoherence between the institutional approaches and the teaching and learning practices carried out by the teachers. The institution is also encouraged to design strategies to achieve a greater appropriation of the pedagogical model; This, through constant and pertinent monitoring of the processes that allow the materialization of its components. Keywords: Constructivist social pedagogical model, pedagogical practices, teaching-learning, didactic strategies, components, follow-up

A convolution integral representation of the thermal Sunyaev-Zel'dovich effect

Analytical expressions for the non-relativistic and relativistic Sunyaev-Zel'dovich effect (SZE) are derived by means of suitable convolution integrals. The establishment of these expressions is based on the fact that the SZE disturbed spectrum, at high frequencies, possesses the form of a Laplace transform of the single line distortion profile (structure factor). Implications of this description of the SZE related to light scattering in optically thin plasmas are discussed.Comment: 11 pages, 2 figures. Accepted for publication in J. Phys.

Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells. OBJECTIVE: We studied here whether deregulation of miR-124 contributes to STAT3 pathway activation in CTCL. METHODS: We measured the effect of ectopic mir-124 expression in active phosphorylated STAT3 (p-STAT3) levels and evaluated the transcriptional impact of miR-124-dependent STAT3 pathway regulation by expression microarray analysis. RESULTS: We found that ectopic expression of miR-124 results in massive downregulation of activated STAT3 in different CTCL lines, which resulted in a significant alteration of genetic signatures related with gene transcription and proliferation such as MYC and E2F. CONCLUSIONS: Our study highlights the importance of the miR-124/STAT3 axis in CTCL and demonstrates that the STAT3 pathway is regulated through epigenetic mechanisms in these cells. Since deregulated STAT3 signaling has a major impact on CTCL initiation and progression, a better understanding of the molecular basis of the miR-124/STAT3 axis may provide useful information for future personalized therapies

Evaluaci?n econ?mica y social de propuesta integral de atenci?n de enfermedades cr?nicas para un envejecimiento exitoso en pacientes adultos del Per? 2019

El envejecimiento poblacional que afecta nuestro pa?s, es el resultado de la ca?da de la tasa de fecundidad, de la mortalidad infantil y el incremento en la esperanza de vida conllevando a la transici?n epidemiol?gica con un predominio de las enfermedades cr?nicas sobre las enfermedades trasmisibles, lo que genera un incremento en el gasto en salud, ya que son de larga evoluci?n y presentan complicaciones que adem?s se caracterizan por generar discapacidad que limita a la persona para desenvolverse laboralmente. Esto se agrava por la poca cultura de prevenci?n en la poblaci?n, falta de gu?as de pr?ctica cl?nica y programas de actualizaci?n continua para el primer nivel de atenci?n, falta de oportunidad de diagn?stico y toma de decisiones terap?uticas y falta de adherencia al tratamiento. Teniendo una preocupante proyecci?n en los siguientes a?os si no se interviene en la poblaci?n susceptible. Por ello nuestra propuesta busca aportar una alternativa basada en la captaci?n de casos no diagnosticados, el seguimiento personalizado, fidelizaci?n y educaci?n continua que mitigue el impacto de las complicaciones. La evaluaci?n de todos los escenarios analizados nos da un VANS positivo por lo que la consideramos recomendable

Ethanol induction of laccase depends on nitrogen conditions of Pycnoporus sanguineus

Background: Ethanol has been pointed out as a laccase inducer. However, there are controversial reports about its efficiencywith some fungi. In this study,we hypothesized that ethanol laccase induced in Pycnoporus sanguineus depends on nitrogen nutriment conditions. To prove this,we assessed laccase production in submerged cultures of P. sanguineus,with different nitrogen concentrations andwith, orwithout ethanol added in a factorial designed experiment. Results: In order to analyze the effects of factors on the response variables, a factorial ANOVA, and response-surface models were performed. It was found that the nitrogen source was the main factor that affected laccase production in P. sanguineus. The treatments with yeast extract (2 g/L) and ethanol (3 g/L) induced the highest laccase activity (31.01 \ub1 4.9 U/L), while the treatments with urea reached the lowest activity (less than 1.6 U/L). Ethanol had positive and synergic effects on laccase production, in accordance with the surface response model, as long as simple nitrogen sources (urea) were not available. Conclusions: We suggest that laccase in P. sanguineus is regulated by a catabolic nitrogen repressionmechanism; laccase activity is strongly inhibited by urea used as nitrogen source and it decreases when the amount of urea increases; contrarily, a synergic positive effect was observed between yeast extract and ethanol on laccase production

Cytotoxic Acetogenins from the Roots of Annona purpurea

Annona purpurea, known in Mexico as "cabeza de negro" or "ilama", belongs to the Annonaceae family. Its roots are employed in folk medicine in several regions of Mexico. Taking that information into account, a chemical and biological analysis of the components present in the roots of this species was proposed. Our results demonstrated that the dichloromethane (DCM) extract was exclusively constituted by a mixture of five new acetogenins named annopurpuricins A-E (1-5). These compounds have an aliphatic chain of 37 carbons with a terminal \u3b1,\u3b2 unsaturated \u3b3-lactone. Compounds 1 and 2 belong to the adjacent bis-THF (tetrahydrofuran) \u3b1-monohydroxylated type, while compounds 3 and 4 belong to the adjacent bis-THF \u3b1,\u3b1'-dihydroxylated type; only compound 5 possesses a bis-epoxide system. Complete structure analysis was carried out by spectroscopy and chemical methods. All compounds were evaluated for their antiproliferative activity on three human tumor cell lines (MSTO-211H, HeLa and HepG2). Compounds 1-4 inhibited significantly the growth of HeLa and HepG2 cells, showing GI50 values in the low/subnanomolar range, while 5 was completely ineffective under the tested conditions. The investigation of the mechanism of action responsible for cytotoxicity revealed for the most interesting compound 1 the ability to block the complex I activity on isolated rat liver mitochondria (RLM)

Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using √s=8 TeV proton-proton collision data

A search for squarks and gluinos in final states containing high-p T jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2012 by the ATLAS experiment in s√=8 TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 20.3 fb−1. Results are interpreted in a variety of simplified and specific supersymmetry-breaking models assuming that R-parity is conserved and that the lightest neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 1330 GeV for a simplified model incorporating only a gluino and the lightest neutralino. For a simplified model involving the strong production of first- and second-generation squarks, squark masses below 850 GeV (440 GeV) are excluded for a massless lightest neutralino, assuming mass degenerate (single light-flavour) squarks. In mSUGRA/CMSSM models with tan β = 30, A 0 = −2m 0 and μ > 0, squarks and gluinos of equal mass are excluded for masses below 1700 GeV. Additional limits are set for non-universal Higgs mass models with gaugino mediation and for simplified models involving the pair production of gluinos, each decaying to a top squark and a top quark, with the top squark decaying to a charm quark and a neutralino. These limits extend the region of supersymmetric parameter space excluded by previous searches with the ATLAS detector

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino

Particle-yield modification in jet-like azimuthal di-hadron correlations in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The yield of charged particles associated with high-$p_{\rm T}$ trigger particles ($8 < p_{\rm T} < 15$ GeV/$c$) is measured with the ALICE detector in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV relative to proton-proton collisions at the same energy. The conditional per-trigger yields are extracted from the narrow jet-like correlation peaks in azimuthal di-hadron correlations. In the 5% most central collisions, we observe that the yield of associated charged particles with transverse momenta $p_{\rm T}> 3$ GeV/$c$ on the away-side drops to about 60% of that observed in pp collisions, while on the near-side a moderate enhancement of 20-30% is found.Comment: 15 pages, 2 captioned figures, 1 table, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/350

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 8 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three leptons and missing transverse momentum is presented. The analysis is based on 20.3 fb−1 of s√ = 8 TeV proton-proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with the Standard Model expectations and limits are set in R-parity-conserving phenomenological Minimal Supersymmetric Standard Models and in simplified supersymmetric models, significantly extending previous results. For simplified supersymmetric models of direct chargino (χ˜±1) and next-to-lightest neutralino (χ˜02) production with decays to lightest neutralino (χ˜01) via either all three generations of sleptons, staus only, gauge bosons, or Higgs bosons, (χ˜±1) and (χ˜02) masses are excluded up to 700 GeV, 380 GeV, 345 GeV, or 148 GeV respectively, for a massless (χ˜01