611 research outputs found
Sex trafficking in Ireland from a health care perspective.
Sex trafficking within Ireland is a hidden phenomenon. In 2010, 78 alleged victims were reported to An Garda Siochina and the recorded levels of human trafficking into Ireland have remained at this level for the last four years. Despite this, no Irish guidelines or referral pathways exist to assist health care professionals. This paper highlights that health care professionals are not aware of this occurrence nor have they been trained to identify victims. Due to a lack of awareness many potential opportunities to detect these victims may be missed. While there is no single set of symptoms or signs that differentiates sex-trafficked victims from other sex workers, an awareness of common physical and psychological health problems associated with sex trafficking by health care professionals may increase victim detection rates. This paper summarises indicators, approach mechanisms, screening questions and a referral guideline relevant to the Irish health care system. This step-by-step guide can be used by health care professionals who encounter such a situation
A metapopulation model for the population dynamics of anopheles mosquito
Please read abstract in the article.This article was co-written by B. Tsanou before he joined the University of Pretoria.http://www.elsevier.com/ locate/amchj2021Mathematics and Applied Mathematic
Canonical Gravity, Diffeomorphisms and Objective Histories
This paper discusses the implementation of diffeomorphism invariance in
purely Hamiltonian formulations of General Relativity. We observe that, if a
constrained Hamiltonian formulation derives from a manifestly covariant
Lagrangian, the diffeomorphism invariance of the Lagrangian results in the
following properties of the constrained Hamiltonian theory: the diffeomorphisms
are generated by constraints on the phase space so that a) The algebra of the
generators reflects the algebra of the diffeomorphism group. b) The Poisson
brackets of the basic fields with the generators reflects the space-time
transformation properties of these basic fields. This suggests that in a purely
Hamiltonian approach the requirement of diffeomorphism invariance should be
interpreted to include b) and not just a) as one might naively suppose. Giving
up b) amounts to giving up objective histories, even at the classical level.
This observation has implications for Loop Quantum Gravity which are spelled
out in a companion paper. We also describe an analogy between canonical gravity
and Relativistic particle dynamics to illustrate our main point.Comment: Latex 16 Pages, no figures, revised in the light of referees'
comments, accepted for publication in Classical and Quantum Gravit
Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma
In metastatic melanoma, it is vital to identify and validate biomarkers of prognosis. Previous studies have systematically evaluated protein biomarkers or mRNA-based expression signatures. No such analyses have been applied to microRNA (miRNA)-based prognostic signatures. As a first step, we identified two prognostic miRNA signatures from publicly available data sets (Gene Expression Omnibus/The Cancer Genome Atlas) of global miRNA expression profiling information. A 12-miRNA signature predicted longer survival after surgery for resection of American Joint Committee on Cancer stage III disease (>4 years, no sign of relapse) and outperformed American Joint Committee on Cancer standard-of-care prognostic markers in leave-one-out cross-validation analysis (error rates 34% and 38%, respectively). A similar 15-miRNA biomarker derived from The Cancer Genome Atlas miRNA-seq data performed slightly worse (39%) than these current biomarkers. Both signatures were then assessed for replication in two independent data sets and subjected to systematic cross-validation together with the three other miRNA-based prognostic signatures proposed in the literature to date. Five miRNAs (miR-142-5p, miR-150-5p, miR-342-3p, miR-155-5p, and miR-146b-5p) were reproducibly associated with patient outcome and have the greatest potential for application in the clinic. Our extensive validation approach highlighted among multiple independent cohorts the translational potential and limitations of miRNA signatures, and pointed to future directions in the analysis of this emerging class of markers
VEP oscillation solutions to the solar neutrino problem
We study the solar neutrino problem within the framework of a parametrized
post-Newtonian formulation for the gravitational interaction of the neutrinos,
which incorporates a violation to the equivalence principle (VEP). Using the
current data on the rates and the energy spectrum we find two possible
oscillation solutions, both for a large mixing angle. One of them involves the
MSW effect in matter and the other corresponds to vacuum oscillations. An
interesting characteristic of this mechanism is that it predicts a semi-annual
variation of the neutrino flux. Our analysis provides new constraints for some
VEP parameters.Comment: revtex, 18 pages, 11 figure
Virtual Compton Scattering off a Spinless Target in AdS/QCD
We study the doubly virtual Compton scattering off a spinless target
within the Anti-de Sitter(AdS)/QCD formalism. We find
that the general structure allowed by the Lorentz invariance and gauge
invariance of the Compton amplitude is not easily reproduced with the standard
recipes of the AdS/QCD correspondence. In the soft-photon regime, where the
semi-classical approximation is supposed to apply best, we show that the
measurements of the electric and magnetic polarizabilities of a target like the
charged pion in real Compton scattering, can already serve as stringent tests.Comment: 21 pages, version to be published in JHEP
Climate-informed stochastic hydrological modeling: Incorporating decadal-scale variability using paleo data
A hierarchical framework for incorporating modes of climate variability into stochastic simulations of hydrological data is developed, termed the climate-informed multi-time scale stochastic (CIMSS) framework. A case study on two catchments in eastern Australia illustrates this framework. To develop an identifiable model characterizing long-term variability for the first level of the hierarchy, paleoclimate proxies, and instrumental indices describing the Interdecadal Pacific Oscillation (IPO) and the Pacific Decadal Oscillation (PDO) are analyzed. A new paleo IPO-PDO time series dating back 440 yr is produced, combining seven IPO-PDO paleo sources using an objective smoothing procedure to fit low-pass filters to individual records. The paleo data analysis indicates that wet/dry IPO-PDO states have a broad range of run lengths, with 90% between 3 and 33 yr and a mean of 15 yr. The Markov chain model, previously used to simulate oscillating wet/dry climate states, is found to underestimate the probability of wet/dry periods >5 yr, and is rejected in favor of a gamma distribution for simulating the run lengths of the wet/dry IPO-PDO states. For the second level of the hierarchy, a seasonal rainfall model is conditioned on the simulated IPO-PDO state. The model is able to replicate observed statistics such as seasonal and multiyear accumulated rainfall distributions and interannual autocorrelations. Mean seasonal rainfall in the IPO-PDO dry states is found to be 15%-28% lower than the wet state at the case study sites. In comparison, an annual lag-one autoregressive model is unable to adequately capture the observed rainfall distribution within separate IPO-PDO states. Copyright Ā© 2011 by the American Geophysical Union.Benjamin J. Henley, Mark A. Thyer, George Kuczera and Stewart W. Frank
Climate-informed stochastic hydrological modeling: Incorporating decadal-scale variability using paleo data
A hierarchical framework for incorporating modes of climate variability into stochastic simulations of hydrological data is developed, termed the climate-informed multi-time scale stochastic (CIMSS) framework. A case study on two catchments in eastern Australia illustrates this framework. To develop an identifiable model characterizing long-term variability for the first level of the hierarchy, paleoclimate proxies, and instrumental indices describing the Interdecadal Pacific Oscillation (IPO) and the Pacific Decadal Oscillation (PDO) are analyzed. A new paleo IPO-PDO time series dating back 440 yr is produced, combining seven IPO-PDO paleo sources using an objective smoothing procedure to fit low-pass filters to individual records. The paleo data analysis indicates that wet/dry IPO-PDO states have a broad range of run lengths, with 90% between 3 and 33 yr and a mean of 15 yr. The Markov chain model, previously used to simulate oscillating wet/dry climate states, is found to underestimate the probability of wet/dry periods >5 yr, and is rejected in favor of a gamma distribution for simulating the run lengths of the wet/dry IPO-PDO states. For the second level of the hierarchy, a seasonal rainfall model is conditioned on the simulated IPO-PDO state. The model is able to replicate observed statistics such as seasonal and multiyear accumulated rainfall distributions and interannual autocorrelations. Mean seasonal rainfall in the IPO-PDO dry states is found to be 15%-28% lower than the wet state at the case study sites. In comparison, an annual lag-one autoregressive model is unable to adequately capture the observed rainfall distribution within separate IPO-PDO states. Copyright Ā© 2011 by the American Geophysical Union.Benjamin J. Henley, Mark A. Thyer, George Kuczera and Stewart W. Frank
A Connection Approach to Numerical Relativity
We discuss a general formalism for numerically evolving initial data in
general relativity in which the (complex) Ashtekar connection and the
Newman-Penrose scalars are taken as the dynamical variables. In the generic
case three gauge constraints and twelve reality conditions must be solved. The
analysis is applied to a Petrov type \{1111\} planar spacetime where we find a
spatially constant volume element to be an appropriate coordinate gauge choice.Comment: 17 pages, LaTe
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