Thermal Regime of a Cold Air Trap in Central Pennsylvania, USA: the Trough Creek Ice Mine

Air temperatures internal and external to a talus cave (‘ice mine’) in central Pennsylvania were measured hourly for three years. Despite its location near the base of a talus slope, the cave demonstrated the thermal characteristics of an apparently static cave, with limited connections to the external environment other than through the cave entrance. Congelation ice that lasted until late spring formed as drip or flowstone and ponded ice from the limited influx of infiltrating water during late winter/early spring. A closed period of thermal stratification and slow warming of cave air was followed by an open period in winter months during which the cave was cooled by the influx of cold dry air. Unlike the occasionally strong and localised cooling induced by the flow of cold air from vents at the base of talus slopes, static cold traps retain their cold air and have little apparent effect on surrounding biota, instead providing potential refugia for organisms that prefer colder temperatures. Published 2012. This article is a U.S. Government work and is in the public domain in the USA

An attempt to identify the extended synchrotron structure associated with the micro-quasar GRS 1915+105

The energy ejected from the galaxy micro-quasar GRS1915+105 in the form of jets is expected to lead to formation of an extended double lobe/hot-spot structure with the energy content comparable to an average supernova remnant. We used the Effelsberg 100m telescope at 10.45 GHz in attempt to identify such structures. For this distant galactic plane source any definite identification was not possible due to high confusion by numerous background sources, however, a few suspect structures were pointed out.Comment: LaTeX uses a new 2001 A&A macro, 4 pages, 2 figures, A&A accepte

Incidence and public health burden of sunburn among beachgoers in the United States.

The beach environment creates many barriers to effective sun protection, putting beachgoers at risk for sunburn, a well-established risk factor for skin cancer. Our objective was to estimate incidence of sunburn among beachgoers and evaluate the relationship between sunburn incidence and sun-protective behaviors. A secondary analysis, of prospective cohorts at 12 locations within the U.S. from 2003 to 2009 (n = 75,614), were pooled to evaluate sunburn incidence 10-12 days after the beach visit. Behavioral and environmental conditions were cross-tabulated with sunburn incidence. Multivariable logistic regression was used to estimate the association between new sunburn and sun-protective behaviors. Overall, 13.1% of beachgoers reported sunburn. Those aged 13-18 years (16.5%), whites (16.0%), and those at beach locations along the Eastern Seaboard (16.1%), had the highest incidence of sunburn. For those spending ≥5 h in the sun, the use of multiple types of sun protection reduced odds of sunburn by 55% relative to those who used no sun protection (Odds Ratio = 0.45 (95% Confidence Interval:0.27-0.77)) after adjusting for skin type, age, and race. Acute health effects of sunburn tend to be mild and self-limiting, but potential long-term health consequences are more serious and costly. Efforts to encourage and support proper sun-protective behaviors, and increase access to shade, protective clothing, and sunscreen, can help prevent sunburn and reduce skin cancer risk among beachgoers

An Examination of Website Advice to Avoid Jury Duty

The use of a jury in legal proceedings can be traced as far back as the participatory democracies that emerged in Greece in the sixth century BC, although it was not until the signing of the Magna Carta that the right to a trial by a jury of one’s peers emerged.1 In the United States, the Sixth and Seventh Amendments of the U.S. Constitution expressly provide this right in both criminal and civil proceedings.2 Furthermore, these amendments provide individuals with the right to a trial before an impartial jury.3 This right intends to serve as a safeguard against unfair treatment during a trial, providing a system of checks and balances to pursue the goal that justice remains at the heart of the legal system. A jury is intended to serve as a cross-section of the community, as it is drawn from and purports to represent the collective community conscience and common sense when resolving disagreements.4 Despite this rich constitutional history and community context, many residents of the United States actively seek to avoid jury service when they are called, for reasons we discuss further below. Some individuals search the Internet for information about how to avoid participating in jury service. As trial judges are tasked with oversight that spans the entire process of impanelment through voir dire, this study sought to provide a contextual background to assist the judiciary in easily recognizing and assessing potential jury avoidance. In the current study, the investigators examined advice offered by popular websites about how reluctant jurors may attempt to be excused from jury service

Loss-of-function genetic diseases and the concept of pharmaceutical targets

The biomedical world relies heavily on the definition of pharmaceutical targets as an essential step in the drug design process. It is therefore tempting to apply this model to genetic diseases as well. However, whereas the model applies well to gain-of-function genetic diseases, it is less suited to most loss-of-function genetic diseases. Most common diseases, as well as gain-of-function genetic diseases, are characterized by the activation of specific pathways or the ectopic activity of proteins, which make well identified targets. By contrast, loss-of-function genetic diseases are caused by the impairment of one protein, with potentially distributed consequences. For such diseases, the definition of a pharmaceutical target is less precise, and the identification of pharmaceutically-relevant targets may be difficult. This critical but largely ignored aspect of loss-of-function genetic diseases should be taken into consideration to avoid the commitment of resources to inappropriate strategies in the search for treatments

Building Interdisciplinary Learning Partnerships

Capital University Law School & Grant Medical Center partnered to provide training on medical malpractice to law students and medical residents. The course utilized a unique, interdisciplinary approach to skills training & professional development. The course attempts to meet several needs: (1) Increase experiential learning opportunities to develop professional skills and judgment; (2) Provide authentic, experiential learning that is cost-effective and accessible to all law students, including non-traditional and part­time students; and (3) Promote interdisciplinary education.https://fuse.franklin.edu/ss2016/1066/thumbnail.jp

The Importance of Data Visualization: Incorporating Storytelling into the Scientific Presentation

From its inception in 2000, one of the primary tasks of the Biomedical Data Reduction Analysis (BDRA) group has been translation of large amounts of data into information that is relevant to the audience receiving it. BDRA helps translate data into an integrated model that supports both operational and research activities. This data integrated model and subsequent visual data presentations have contributed to BDRA's success in delivering the message (i.e., the story) that its customers have needed to communicate. This success has led to additional collaborations among groups that had previously not felt they had much in common until they worked together to develop solutions in an integrated fashion. As more emphasis is placed on working with "big data" and on showing how NASA's efforts contribute to the greater good of the American people and of the world, it becomes imperative to visualize the story of our data to communicate the greater message we need to share. METHODS To create and expand its data integrated model, BDRA has incorporated data from many different collaborating partner labs and other sources. Data are compiled from the repositories of the Lifetime Surveillance of Astronaut Health and the Life Sciences Data Archive, and from the individual laboratories at Johnson Space Center that support collection of data from medical testing, environmental monitoring, and countermeasures, as designated in the Medical Requirements Integration Documents. Ongoing communication with the participating collaborators is maintained to ensure that the message and story of the data are retained as data are translated into information and visual data presentations are delivered in different venues and to different audiences. RESULTS We will describe the importance of storytelling through an integrated model and of subsequent data visualizations in today's scientific presentations and discuss the collaborative methods used. We will illustrate the discussion with examples of graphs from BDRA's past work supporting operations and/or research efforts

Mental Action Simulation Synchronizes Action-Observation Circuits across Individuals

A frontoparietal action–observation network (AON) has been proposed to support understanding others' actions and goals. We show that the AON "ticks together" in human subjects who are sharing a third person's feelings. During functional magnetic resonance imaging, 20 volunteers watched movies depicting boxing matches passively or while simulating a prespecified boxer's feelings. Instantaneous intersubject phase synchronization (ISPS) was computed to derive multisubject voxelwise similarity of hemodynamic activity and inter-area functional connectivity. During passive viewing, subjects' brain activity was synchronized in sensory projection and posterior temporal cortices. Simulation induced widespread increase of ISPS in the AON (premotor, posterior parietal, and superior temporal cortices), primary and secondary somatosensory cortices, and the dorsal attention circuits (frontal eye fields, intraparietal sulcus). Moreover, interconnectivity of these regions strengthened during simulation. We propose that sharing a third person's feelings synchronizes the observer's own brain mechanisms supporting sensations and motor planning, thereby likely promoting mutual understanding.Peer reviewe

ACES: Analysis of Conservation with an Extensive list of Species

MOTIVATION: An abundance of new reference genomes is becoming available through large-scale sequencing efforts. While the reference FASTA for each genome is available, there is currently no automated mechanism to query a specific sequence across all new reference genomes. RESULTS: We developed ACES (Analysis of Conservation with an Extensive list of Species) as a computational workflow to query specific sequences of interest (e.g., enhancers, promoters, exons) against reference genomes with an available reference FASTA. This automated workflow generates BLAST hits against each of the reference genomes, a multiple sequence alignment file, a graphical fragment assembly file, and a phylogenetic tree file. These data files can then be used by the researcher in several ways to provide key insights into conservation of the query sequence. AVAILABILITY: ACES is available at https://github.com/TNTurnerLab/ACES. SUPPLEMENTARY INFORMATION: Supplementary Figure 1 is available online in Bioinformatics