Technical Specification for the CLIC Two-Beam Module

A high-energy (0.5-3 TeV centre-of-mass), highluminosity Compact Linear Collider (CLIC) is being studied at CERN [1]. The CLIC main linacs, 21-km long each, are composed of 2-m long two beam modules. This paper presents their current layout, the main requirements for the different sub-systems (alignment, supporting, stabilization, cooling and vacuum) as well as the status of their integration

Способы управления параметрами вибрации пассажирских вагонов

[For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version)].ABSTRACT When the car building plant in Tver began serial production of new generation passenger cars, its specialists had to face the facts of not always justified modification of, it would seem, already comfortable and safe designs. In particular, weakened vibration parameters during the construction of lounge cars, bars, laboratories were found out. The feasibility of reducing the vibration indicators of the lounge car by increasing the bending stiffness of the body and selecting the most rational vertical damper of the central suspension is given. Keywords: railway, car building, lounge car, vibration, smooth running, bending stiffness, design, testing, parameters’ control.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).Когда вагоностроительный завод в Твери начал серийный выпуск пассажирских вагонов нового поколения, его специалистам пришлось столкнуться с фактами не всегда оправданной модификации, казалось бы, уже и без того более комфортных и безопасных конструкций. В частности, обнаружились ослабления вибрационных параметров при постройке вагонных салонов, баров, лабораторий. Дано обоснование возможности уменьшения показателей вибрации вагона-салона за счёт увеличения изгибной жесткости кузова и подбора наиболее рационального вертикального демпфера центрального подвешивания

Исследование прочности кузовов вагонов электропоезда нового поколения

Basing on computational-experimental methods, theoretical and experimental studies were carried out in Tver on carrying capacity of car bodies of electric trains of the new generation EG2Tv under the influence of various normative stresses. Based on the preliminary evaluation of stress-strain state individual components of the metal structure of bodies were changed. The results of static strength tests showed that the main indicators of strength of the body fully comply with the requirements of standards and thus the rationality of the decisions made is confirmed. Taking into account the positive results of the tests, the bodies were transferred for further tests, namely, to determine the parameters of flexural vibrations.В Твери на основе расчётно--экспериментальных методов проведены теоретические и экспериментальные исследования несущей способности кузовов вагонов электропоезда нового поколения ЭГ2Тв при воздействии различных нормативных нагрузок. На основании предварительной оценки напряжённо-деформированного состояния отдельные узлы металлоконструкции кузовов были изменены. Результаты прочностных статических испытаний показали, что по основным показателям прочности кузова полностью соответствуют требованиям нормативов и тем самым подтверждается рациональность принятых решений. С учётом положительных результатов испытаний кузова были переданы для дальнейших испытаний, а именно для определения параметров изгибных колебаний

Differential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals

We previously examined the expression of specific C-terminal μ-opioid receptor (MOR) splice variants in human central nervous system cell types and HIV-infected brain tissue from subjects with neurocognitive impairment ± HIV encephalitis (HIVE). In the present study, we examined the N-terminal splice variant MOR-1K which mediates excitatory cellular signaling

Epiregulin and EGFR interactions are involved in pain processing

The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing. We show that inhibition of EGFR with clinically available compounds strongly reduced nocifensive behavior in mouse models of inflammatory and chronic pain. EREG-mediated activation of EGFR enhanced nociception through a mechanism involving the PI3K/AKT/mTOR pathway and matrix metalloproteinase-9. Moreover, EREG application potentiated capsaicin-induced calcium influx in a subset of sensory neurons. Both the EGFR and EREG genes displayed a genetic association with the development of chronic pain in several clinical cohorts of temporomandibular disorder. Thus, EGFR and EREG may be suitable therapeutic targets for persistent pain conditions

CLIC two-beam module design and integration

Abstract The Compact LInear Collider (CLIC) is based on twobeam acceleration concept currently developed at CERN. The RF power is generated by a high-current electronbeam, called Drive Beam, (DB) running parallel to the Main Beam (MB). The DB is decelerated in dedicated power extraction structures (PETS) and the generated RF power is transferred via waveguides to the accelerating structures (AS). To facilitate the matching of the beams, components are assembled in 2-m long modules of few different types. Special modules are needed in damping regions or to contain dedicated instrumentation and vacuum equipment. The module design and integration has to cope with challenging requirements from the different technical systems. This paper reports the status of the engineering design and related technical issues

Developing the architecture of an IT company to create hypercasual games

На текущий момент в науке существуют различные решения отдельных прикладных задач, которые касаются построения архитектуры различных IT-компаний или анализа данной архитектуры, но решение такого вопроса как проектирование архитектуры IT-компании, которая занимается разработкой гиперказуальных игр отсутствует. Это влечет за собой трудность и мешает эффективному управлению компанией. В данной работе на основе существующей методики описания архитектуры предложен свой построения уникальной архитектуры компании по разработке гиперказуальных игр.At the moment in science there are various solutions of separate applied problems, which concern the construction of the architecture of various IT companies or analysis of this architecture, but there is no solution to such a question as designing the architecture of an IT company that develops hypercasual games. This entails difficulty and hinders the effective management of the company. In this paper, based on the existing methodology for describing the architecture, we propose a unique architecture of a hypercasual game development company

CLIC TWO-BEAM MODULE FOR THE CLIC CONCEPTUAL DESIGN AND RELATED EXPERIMENTAL PROGRAM*

The CLIC (Compact LInear Collider) study is a site independent study exploring technological developments to extend linear colliders into the Multi-TeV colliding beam energy range. The two-beam linear accelerator being studied at CERN involves the design and integration of many different technical systems, tightly bound and influencing each other. For the construction of two linacs it has been decided to proceed with a modular design, and repetitive two-beam modules of a few types were defined. The modules consist of micron-level precision components operating under ultra-high vacuum as required by the beam physics. For the CLIC Conceptual Design Report, the development and system integration is mainly focused on the most complex module type containing the highest number of components and technical systems. For proving the proper functioning of the needed technical systems and confirming their feasibility it has been decided to build four prototype modules and test them without beam. In addition, three modules have to be produced in parallel for tests with beam in the CLIC Experimental Area. This paper is focused on the design of the different technical systems and integration issues of the two-beam module. The experimental program for the prototype modules is also recalled

FABRICATION AND VALIDATION OF THE PROTOTYPE SUPPORTING SYSTEM FOR THE CLIC TWO-BEAM MODULES

The micron-precision RF structures are mounted and aligned on specially developed supporting girders, which provide stability and re-positioning. The supporting girders have stiffness and damping specifications imposed by stringent beam physics and RF requirements. In addition, several constraints, such as allocated space and weight limitation have to be taken into consideration. This paper describes different support concepts following various fabrication techniques and materials. Extensive qualification measurements have been performed on the first prototype units, and the main results are also reported