The trend in the development of a system that combines the placement and use of tangible assets such as warehouses, terminals, and storage facilities of enterprises

The article discusses the idea of creating an Internet resource in order to combine the needs and offers of services for storage, transportation, rental of warehouses, premises, open storage areas, etc. in the Tomsk region

The dynamics of near-surface prismatic loops in lead

The paper proposes the study of the dynamics of near-surface dislocation loops in lead. It has been shown that the activation of a prismatic near-surface dislocation loop and its motion inward the crystal practically throughout the entire path occurs at a high velocity close to the speed of sound in metal. The kinetic energy per unit length of the dislocation loop during its motion decreases linearly and weakly depends on the density of dislocations in metal. Moreover, a weak dependence of the path length and the path time of a prismatic loop on the dislocation density in lead is observed

Дослідження морфофункціональних особливостей розвитку експериментальних металонефропатій = The study of morphofunctional features of the development of experimental metallonephropathy

Gozhenko A. I., Lugovskoy S. P., Samokhina N. A. Дослідження морфофункціональних особливостей розвитку експериментальних металонефропатій = The study of morphofunctional features of the development of experimental metallonephropathy. Journal of Education, Health and Sport. 2016;6(4):287-296. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50201http://ojs.ukw.edu.pl/index.php/johs/article/view/3473 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016. ДОСЛІДЖЕННЯ МОРФОФУНКЦІОНАЛЬНИХ ОСОБЛИВОСТЕЙ РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНИХ МЕТАЛОНЕФРОПАТІЙ  А. І. Гоженко, С. П. Луговський, Н. А. Самохіна  Державне підприємство «Український науково-дослідний інститутмедицини транспорту МОЗ України», м. Одеса, Украина РезюмеПроведені експериментальні дослідження щодо тривалого впливу солей кадмію, ртуті, свинцю в дозі 1/50 від DL50 на нирки показали, що важливим аспектом їх дії є зміна показників азотистого обміну, яка проявлялась підвищеним вмістом креатиніну, сечовини та сечової кислоти в сироватці крові, а також високим вмістом білку в сечі. Характерною ознакою ураження нирок є зниження швидкості клубочкової фільтрації, яка визначалась при дії всіх трьох досліджуваних нефротоксикантів: при дії Cd – зниження на 23,6 %, при дії Pb – на 22,1 %, при дії Hg – 28,9 %. Морфологічні дослідження дозволили встановити нові факти, щодо морфологічної характеристики токсичної дії неорганічних сполук Cd, Hg, Pb, які полягають у здатності металів викликати цитопатичну дію на окремі клітини структурних елементів нефрону. Провідним механізмом розвитку експериментальних металонефропатій є ураження епітелію проксимальних канальців нирок, яке зумовлено вибірковим порушенням клітинних мембран, мітохондрій і лізосом епітелію проксимальних канальців нефрону.Ключові слова: важкі метали, нирки, металонефропатії, креатинін, сечовина, білок, швидкість клубочкової фільтрації, гістологічне дослідження нирок, канальцевий апарат, епітеліоцити. THE STUDY OF MORPHOFUNCTIONAL FEATURES OF THE DEVELOPMENT OF EXPERIMENTAL METALLONEPHROPATHY A. I. Gozhenko, S. P. Lugovskoy, N. A. Samokhina  Ukrainian Scientific and Research Institute of Transport Medicine, Odessa SummaryEexperimental studies of prolonged exposure of cadmium salts, mercury, lead in the dose of from 1/50 DL50 on the kidney have shown that an important aspect of their actions is the change of indicators of nitrogen metabolism, which was manifested by increased creatinine, urea and uric acid in serum and high urine protein excretion. A characteristic feature of renal disease is the decline in glomerular filtration rate, which was defined when all three of the studied nephrotoxicants: under the Cd decrease by 23,6 %, under the action of Pb - 22,1 %, under the action of Hg – 28,9 %. Morphological studies revealed new facts concerning the morphological characteristics of toxic action of inorganic compounds of Cd, Hg, Pb, which lies in the ability of metals to cause cytopathic effect on individual cells of the structural elements of the nephron. The main mechanism for the development of experimental metallonephropathy is the damage to the epithelium of the proximal tubules of the kidneys, due to a selective disturbance of cellular membranes, mitochondria and lysosomes in the epithelium of the proximal tubules of the nephron.Key words: heavy metals, kidneys, metallonephropathy, creatinine, urea, protein, glomerular filtration rate, and histological examination of the kidneys, tubular apparatus, the epithelial cells. ИССЛЕДОВАНИЕ МОРФОФУНКЦИОНАЛЬНЫХ ОСОБЕННОСТЕЙ РАЗВИТИЯ ЭКСПЕРИМЕНТАЛЬНЫХ МЕТАЛЛОНЕФРОПАТИЙ  А. И. Гоженко, С. П. Луговской, Н. А. Самохина Украинский НДИ медицины транспорта, г.Одесса РезюмеПроведенные экспериментальные исследования длительного воздействия солей кадмия, ртути, свинца в дозе 1/50 DL50 на почки показали, что важным аспектом их действия является изменение показателей азотистого обмена, которое проявлялось повышенным содержанием креатинина, мочевины и мочевой кислоты в сыворотке крови, а также высоким содержанием белка в моче. Характерным признаком поражения почек является снижение скорости клубочковой фильтрации, которая определялась при действии всех трех исследуемых нефротоксикантов: при действии Cd – снижение на 23,6 %, при действии Pb – на 22,1 %, при действии Hg – 28,9 %. Морфологические исследования позволили установить новые факты, относительно морфологической характеристики токсического действия неорганических соединений Cd, Hg, Pb, которые заключаются в способности металлов вызывать цитопатическое действие на отдельные клетки структурных элементов нефрона. Ведущим механизмом развития экспериментальных металонефропатий является поражение эпителия проксимальных канальцев почек, которое обусловлено выборочным нарушением клеточных мембран, митохондрий и лизосом эпителия проксимальных канальцев нефрона.Ключевые слова: тяжелые металлы, почки, металлонефропатии, креатинин, мочевина, белок, скорость клубочковой фильтрации, гистологическое исследование почек, канальцевый аппарат, эпителиоциты

Fluorine concentration in snow cover within the impact area of aluminium production plant (Krasnoyarsk city) and coal and gas-fired power plant (Tomsk city)

The fluorine contents in snow melt water find in the impact areas of aluminum production plant and coal and gas-fired power plant are compared. In melt water, soluble fluoride is found in the form of fluoride ion, the content of which was determined by the potentiometric method using ion-selective electrode. According to the measurements of 2013-2014, fluoride content in melt water ranges 10.6-15.4 mg/dm{3} at the distance 1-3 km from the borders of Krasnoyarsk aluminum plant with the mean value 13.1 mg/dm{3}. Four-year monitoring from 2012 to 2015 in the impact area of Tomsk coal and gas-fired power plant showed that fluoride content in melt water in vicinity of the thermal power plant is significantly lower than in the samples from the impact area of the aluminum plant. But higher content of fluoride ion (0.2-0.3 mg/dm{3}) in snow samples in vicinity of coal and gas-fired power plant was revealed in winter of 2015. Intake of soluble fluoride is mostly explained by dust-aerosol emissions of study plants and deposition of fluorine compounds from air

Analysis of Microcrafters in Materials Specimens after Long-Term Exposure on ISS Surface

The "Komplast" experiment has been carried out on the ISS by the Khrunichev Space Center jointly with other Russian scientific centers since 1998. The experiment incorporates the "Komplast" cartridges on the FGB exterior, which are fitted with materials specimens and sensors. The cartridges were sent into orbit together with FGB on 20 November 1998. In March 2011, two of the cartridges were taken back from the ISS by the "Discovery" American space shuttle after being exposed in the open space for 12 years. In the framework of this experiment the subject of analysis is the effect of the space environment on the exposed specimens of various materials. This report covers the analysis results of the surface morphology of various materials taken from the "Komplast" cartridges exposed to hits of micrometeors and micronic particles of space debris. Analysis is made of microcraters of 5 to 250 mcm in specimens of polished metals and silicone comprised in the sensor for micrometeoric particles. The report represents optic and scanning electron microscope images of craters formed in the specimens by high-velocity and low-velocity particles impacting the surface. By virtue of the electronic microscope, data on composition of the substance in the craters and of the substance of the low-velocity particles are obtained. The data make it possible to differentiate the particles as the natural-origin particles or anthropogenic-origin space debris particles. Distribution of craters and low-velocity particles in the size range of 5 to 50 mcm is obtained. The data are compared with the existing models of fluxes of natural-origin and artificial-origin microparticles on the ISS orbit. Inhomogeneous particles of complicated configuration are discovered on the surface of the analyzed specimens, whose origin are not uniquely determined and are to be the subject of further study

A Study of Micro Craters in Material Samples after Long Duration Exposure on ISS Komplast Panels

The Komplast materials experiment was designed by the Khrunichev State Research and Production Space Center, together with other Russian scientific institutes, and has been carried out by Mission Control Moscow since 1998. Komplast panels fitted with material samples and sensors were located on the International Space Station (ISS) Functional Cargo Block (FGB) module exterior surface. Within the framework of this experiment, the purpose was to study the effect of the low earth orbit (LEO) environment on exposed samples of various materials. The panels were sent into orbit with the FGB when it launched on November 20, 1998.

Дослідження нефропротекторної дії чорниці при експериментальних металонефропатіях

Experimental studies of the effect of heavy metals, in particular, the salts of cadmium and lead, on the activity of the antioxidant system of the kidneys have been carried out and also the nephroprotective properties of the polyphenol complex of blueberries has been investigated. A positive effect of the drug in question characterized by a stimulation of the antioxidant defense system, an activation of the enzymes of the glutathione antioxidant system (GAOS) as well as increased levels of the elimination of heavy metals from the body.Проведены экспериментальные исследования влияния тяжелых металлов, в частности, солей кадмия и свинца, на активность антиоксидантной системы почек, а также изучены нефропротекторные свойства полифенольного комплекса черники. Выявлен позитивный эффект препарата, который характеризуется стимулированием системы антиоксидантной защиты, активацией ферментов ГАОС, а также ростом уровней элиминации тяжелых металлов из организма.Проведені експериментальні дослідження щодо впливу важких металів, зокрема солей свинцю та кадмію, на активність антиоксидантної системи нирок, а також досліджено нефропротекторні властивості поліфенольного комплексу чорниці. Виявлено позитивний ефект даного препарату, який характеризується стимулюванням системи антиоксидантного захисту, активацією ферментів глутатіонантиоксидантної системи (ГАОС), а також підвищенням рівнів елімінації важких металів з організму

Myofascial pain syndrome: risk factors, diagnosis and local therapy

One of the main reasons for seeking medical help is myofascial syndrome (MFS), which is manifested by local inflammation with elements of degenerative changes in the affected tissue, pain and muscle spasm due to dysfunctional disorders in the nociceptive system and a decrease in the quality of life. This review discusses etiopathogenesis in detail, taking into account the factors predisposing to the development of MFS, which are divided into anatomical, ergonomic, medical and psychosocial, and also provides diagnostic criteria for pain MFS, including 5 large and 3 small criteria necessary for diagnosis. The second part of the review examines the indications, efficacy, safety, and benefits of topical forms of nonsteroidal anti-inflammatory drugs (NSAIDs), which have a moderate effect on pain, but have a much better safety profile due to reduced systemic absorption. The use of topical drugs allows you to create an effective concentration of the drug directly in the lesion and avoid undesirable systemic effects. Experts strongly recommend prescribing primarily topical, rather than oral, NSAIDs to patients aged 65 years and older who have concomitant cardiovascular and renal pathology, as well as diseases of the gastrointestinal tract. In more detail, the review examines topical forms of diclofenac, which differ in the maximum degree of transdermal penetration compared to other NSAIDs and the effect of slow release of the active substance into the surrounding tissues