Аналіз змін системи згортання крові у хворих на гіпертонічну хворобу в поєднанні з хронічним обструктивним захворюванням легень різного ступеня важкості

Aim of research was to determine the influence of COPD severity on the plasma hemostasis condition in patients with HT combined with COPD.Materials and methods. 79 patients were examined: 15 almost healthy (control) and 64 patients with stage II HT with concomitant COPD. Depending on the COPD severity, the patients were divided into 3 groups: group A- 11 patients with HT and COPD of the I severity degree; Group B - 28 patients with HT and COPD of the II severity degree; Group B - 25 patients HT and COPD of the III severity degree. Special laboratory tests: coagulation indicators - activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen, soluble fibrin monomer complexes, ancistron test, Lebetox test, and echitox test were carried out.Results: in result of the study it was found that comorbid HT and COPD course is characterized by increased activity of hemostasis system coagulation level, which intensity is associated with bronchial obstruction severity. In particular, COPD of the III severity degree hyperfibrinogenemia, as well as soluble fibrin monomer complexes significant increase were observed in all subgroups of the patients with HT and COPD, accompanied by activation of external pathway of coagulation and combined with accelerated processes of prothrombinase-,  trombino- and fibrin formation according to specific snake venoms tests.Conclusion. Comorbid HT and COPD course is characterized by the activation of hemostasis system coagulation level, which intensity is associated with bronchial obstruction severity. Hyperfibrinogenemia and a significant increase of the SFMC content, observed in all subgroups of the patients with HT and COPD, at COPD of the III severity degree are accompanied by activation of external pathway of coagulation and combined with accelerated processes of prothrombinase-,  trombino- and fibrin formation according to specific snake venoms tests. The patients with HT combined with COPD of the III severity degree need careful laboratory monitoring to solve the problem of the additional antithrombotic correction necessityМетою дослідження було встановити вплив ступеню важкості хронічного обструктивного захворювання легень  на стан плазмового гемостазу у хворих із поєднаним перебігом гіпертонічної хвороби та ХОЗЛ. В результаті роботи виявлено, що коморбідний перебіг ГХ та ХОЗЛ характеризується підвищенням активності згортуючої ланки системи гемостазу, вираженість якої асоціюється із ступенем важкості бронхообструкці

Peculiarities of platelet hemostasis changes in COPD - hypertensive disease mixed patients

Samoilova Svitlana O., Plenova Olga M. Peculiarities of platelet hemostasis changes in COPD - hypertensive disease mixed patients. Journal of Education, Health and Sport. 2016;6(4):39-44. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49394 http://ojs.ukw.edu.pl/index.php/johs/article/view/3445   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.03.2016. Revised 20.03.2016. Accepted: 05.04.2016.     Peculiarities of platelet hemostasis changes in COPD - hypertensive disease mixed patients   Svitlana O. Samoilova, Olga M. Plenova   O.O.Bohomolets National Medical University   Abstract   Disorders in the hemostasis system have a major impact on the disease course and complication in the hypertensive disease and chronic obstructive pulmonary disease patients. To assess the platelet hemostasis we examined 62 persons: 15 apparently healthy (Control Group), 15 HD patients without COPD, 17 HD patients with COPD associated, and 15 COPD patients of Degree II and III. We have found out that HD, COPD and the mix patients demonstrate an increased thrombocyte functional activity expressed in a higher degree of spontaneous aggregation, and significant activation of arachidonic acid induced thrombocyte aggregation. The HD patients feature a specific increase of adrenalin induced aggregation, contrary to other examined groups, that may be explained by a role of sympathetic nervous system in the HD pathogenesis. Chronic inflammation in the COPD patients is accompanied with a significant increase of arachidonic acid thrombocyte reaction (the highest among all examined groups) that should be taken into account when establishing a treatment policy with anti-inflammatory agents included.   Key words: hypertensive disease, chronic obstructive pulmonary diseases, hemostasis, thrombocytes, aggregation