The non-technical skills needed by graduates of technical colleges in metalwork technology

This study centered on the views of the professionals about the non-technical skills considered crucial as recruitment prerequisite among graduates of metalwork technology from technical and vocational institutions in Nigeria. It will also examine the possibility of integrating these skills into the curriculum. The study made use of the survey research design. One research question guided the study. The population for the study comprised metalwork technology professionals in Ogun State, Southwestern Nigeria. A 36-item questionnaire was the instrument used for data collection. The instrument was validated by experts from the University of Lagos (UNILAG). The reliability of the instrument was determined using Cronbach Alpha and the reliability index which stood at 0.79. The data collected were analysed using mean statistic and standard deviation. The study revealed that professionals placed great importance on communication skills, problem-solving skills, teamwork skills and self-management qualities among others, as important recruitment prerequisite among graduates of metalwork technology from technical and vocational institutions in Nigeria. The study concludes with the suggestions that non-technical skills should be integrated into the curriculum particularly in the field of metalwork technology in technical colleges. Students should be familiar with the employers’ recruitment criteria while they are still in schools in order to equip them with the necessary skills needed for employment

The Association of AMPK with ULK1 Regulates Autophagy

Autophagy is a highly orchestrated intracellular bulk degradation process that is activated by various environmental stresses. The serine/threonine kinase ULK1, like its yeast homologue Atg1, is a key initiator of autophagy that is negatively regulated by the mTOR kinase. However, the molecular mechanism that controls the inhibitory effect of mTOR on ULK1-mediated autophagy is not fully understood. Here we identified AMPK, a central energy sensor, as a new ULK1-binding partner. We found that AMPK binds to the PS domain of ULK1 and this interaction is required for ULK1-mediated autophagy. Interestingly, activation of AMPK by AICAR induces 14-3-3 binding to the AMPK-ULK1-mTORC1 complex, which coincides with raptor Ser792 phosphorylation and mTOR inactivation. Consistently, AICAR induces autophagy in TSC2-deficient cells expressing wild-type raptor but not the mutant raptor that lacks the AMPK phosphorylation sites (Ser722 and Ser792). Taken together, these results suggest that AMPK association with ULK1 plays an important role in autophagy induction, at least in part, by phosphorylation of raptor to lift the inhibitory effect of mTOR on the ULK1 autophagic complex

Cells of the adult human heart

Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies

Cells of the adult human heart

Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies

Factors Affecting Farmers Tendency towards Joining the Production Cooperatives of the Tabas City

Considering the important position of the country's production cooperatives (i.e. the most advanced stage of cooperation) in development and stability of rural areas, the current study aims to identify and evaluate the factors affecting farmer's tendency towards joining production cooperatives in Tabas City, Yazd Province in 2007-2008. Statistical population of the study consists of 1418 individuals, 32 women and 1386 men and the sample size of 120 persons was determined using Cochrane Formula. The prepared questionnaires were distributed using simple random method. The gathered data were analyzed using SPSS 11.5 utilizing Spearman Correlation and Mann Whitney Tests in two sections, Descriptive (determining frequency and frequency percentage, mean, standard deviation and etc) and Analytic or Inferential. The most important descriptive results are: 1- Cooperative companies have suitable basis for attracting individuals' participation, 2- Agricultural inputs provided by the cooperatives to the members contribute to farmers' tendency towards joining, 3- The most effective information source of the members in their profession are rural production cooperative companies. The most important analytical and inferential results are: 1- Proximity of residence and the production cooperative company has significant meaning for the tendency of individuals to become a member, 2- There is a significant relationship between the managing director and the tendency of individuals to become a member, 3- Using Mann Whitney, there are significant differences between satisfaction, need, motivation, knowing the company, capital growth (each one individually) and the individuals' tendency to become a member

Longitudinal Determinants of Married Women's Autonomy in Egypt.

This article explores determinants of women's autonomy in Egypt around the beginning of the 'Arab Spring' in 2011. We show that women's autonomy over time is a product not only of their individual characteristics, but also of the household and community environment in which they live. Using the 2006 and 2012 Egyptian Labor Market Panel Survey (ELMPS) and multilevel models, results demonstrate that women's autonomy changes over time. There are large and consistent variations in women's autonomy by household region of residence and wealth. For example, women in the rural and urban Upper Egypt region are less autonomous than women in the Cairo region, and women in wealthier households are less autonomous compared to the poorest households. Programs aiming to increase women's autonomy focus exclusively or primarily on women's own characteristics. These results indicate that strategies to improve women's autonomy should be mindful of the multiple dimensions of autonomy and have a programmatic focus on changing household and social environments

Longitudinal Determinants of Married Women's Autonomy in Egypt.

This article explores determinants of women's autonomy in Egypt around the beginning of the 'Arab Spring' in 2011. We show that women's autonomy over time is a product not only of their individual characteristics, but also of the household and community environment in which they live. Using the 2006 and 2012 Egyptian Labor Market Panel Survey (ELMPS) and multilevel models, results demonstrate that women's autonomy changes over time. There are large and consistent variations in women's autonomy by household region of residence and wealth. For example, women in the rural and urban Upper Egypt region are less autonomous than women in the Cairo region, and women in wealthier households are less autonomous compared to the poorest households. Programs aiming to increase women's autonomy focus exclusively or primarily on women's own characteristics. These results indicate that strategies to improve women's autonomy should be mindful of the multiple dimensions of autonomy and have a programmatic focus on changing household and social environments