Analysis of the Socio-Economic Impacts of a Proposed Highway between Nuevo Italia and Puerto Breu, Peru

Road building is increasingly promoted in the borderlands shared by Peru and Brazil despite an incomplete understanding of the socio-environmental impacts of transportation infrastructure in the region. Amazonian roads often expand informally, without official government process, previous consultation by Indigenous populations, and environmental impact statements.. Amazonian road expansion also often follows a progressive feedback cycle, with new, unplanned roads begetting illegal logging pathways and agricultural expansion which in turn expands and formalizes road systems. One expanding road system is developing between the Ucayali River and the remote headwaters of the Yurua/Jurua River. The Carretera Yurua (officially trail UC-105), extended approximately300 km long in August 2020. Existing research suggests that the unplanned construction of the Yurua road, which originally began as informal logging roads extending off a road to explore fossil fuels, could result in significant land changes and will facilitate ranching, additional illegal timber harvesting, and coca farming, threatening global biodiversity hotspots and conservation areas, and endangered Indigenous cultures and territories. This research spatially analyzes the different waterways, cultural territories, conservation areas and other administrative units crossed by the proposed road. Additional analysis includes the deforestation footprint and downstream impacts of the road. Methods include GIS analysis and remote sensing along with document and internet research of news articles, legal documents, social media communications, interviews from key actors, and studies of similar infrastructure projects in the bio-culturally diverse Amazon borderlands

Analysis of the Socio-Environmental Impacts of the Proposed Transboundary Highway between Pucallpa, Peru and Cruzeiro do Sul, Brazil

As road building across the Amazon continues to be proposed by both Brazilian and Peruvian governments, it becomes increasingly important to consider the effects this infrastructure could have on diverse Amazonian cultures and ecosystems. One proposal being discussed is a 200 km road that would connect the cities of Pucallpa, Peru and Cruzeiro do Sul, Brazil. While promoted as economically beneficial, the road could infringe upon protected conservation areas and indigenous lands, bringing illegal activity with it as well. This research aims to evaluate the potential impacts the Pucallapa-Cruzeiro do Sul road project presents to the ecosystems, societies, and economies of the southwestern Amazon using a mixed methodology including geospatial analysis, remote sensing, and a literature review of previous studies on the impact of roads in tropical forests. These analyses will attempt to express the scale of the repercussions that road construction may bring to the bioculturally rich Amazon borderlands

Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.

Altered brain metabolism is associated with progression of Alzheimer's Disease (AD). Mitochondria respond to bioenergetic changes by continuous fission and fusion. To account for three dimensional architecture of the brain tissue and organelles, we applied 3-dimensional electron microscopy (3D EM) reconstruction to visualize mitochondrial structure in the brain tissue from patients and mouse models of AD. We identified a previously unknown mitochondrial fission arrest phenotype that results in elongated interconnected organelles, "mitochondria-on-a-string" (MOAS). Our data suggest that MOAS formation may occur at the final stages of fission process and was not associated with altered translocation of activated dynamin related protein 1 (Drp1) to mitochondria but with reduced GTPase activity. Since MOAS formation was also observed in the brain tissue of wild-type mice in response to hypoxia or during chronological aging, fission arrest may represent fundamental compensatory adaptation to bioenergetic stress providing protection against mitophagy that may preserve residual mitochondrial function. The discovery of novel mitochondrial phenotype that occurs in the brain tissue in response to energetic stress accurately detected only using 3D EM reconstruction argues for a major role of mitochondrial dynamics in regulating neuronal survival

Blood pressure and lipid goal attainment in the hypertensive population in the primary care setting in Spain

[Abstract] Although blood pressure (BP) control is crucial in hypertensive patients, clinical practice guidelines agree that the goal of treatment should be aimed at not only decreasing BP but reducing global cardiovascular risk. The aim of this cross-sectional study was to evaluate BP, low-density lipoprotein cholesterol (LDL-C), and composite control rates in a hypertensive population in a primary care setting in Spain. Good BP control was defined as <140/90 mm Hg (<130/80 mm Hg for diabetics).LDL-C control rate was established according to the third report of the National Cholestrol Education Program Adult Treatment Panel criteria. A total of 12,954 patients (49.9% women, aged 62.1±10.7 years) were included. BP was controlled in 24.8% of patients, LDL-C in 26% of patients and, when combined, in only 8.6%. The rates of control were significantly worse in high-risk subgroups, such as high-coronary-risk, diabetic, or metabolic syndrome patients. The BP and LDL-C control rates in the hypertensive population attended to daily in primary care settings in Spain are low