The June 2016 Optical and Gamma-Ray Outburst and Optical Micro-Variability of the Blazar 3C454.3

The quasar 3C454.3 underwent a uniquely-structured multi-frequency outburst in June 2016. The blazar was observed in the optical $R$ band by several ground-based telescopes in photometric and polarimetric modes, at $\gamma$-ray frequencies by the \emph{Fermi}\ Large Area Telescope, and at 43 GHz with the Very Long Baseline Array. The maximum flux density was observed on 2016 June 24 at both optical and $\gamma$-ray frequencies, reaching $S^\mathrm{max}_\mathrm{opt}=18.91\pm0.08$ mJy and $S_\gamma^\mathrm{max} =22.20\pm0.18\times10^{-6}$ ph cm$^{-2}$ s$^{-1}$, respectively. The June 2016 outburst possessed a precipitous decay at both $\gamma$-ray and optical frequencies, with the source decreasing in flux density by a factor of 4 over a 24-hour period in $R$ band. Intraday variability was observed throughout the outburst, with flux density changes between 1 and 5 mJy over the course of a night. The precipitous decay featured statistically significant quasi-periodic micro-variability oscillations with an amplitude of $\sim 2$-$3\%$ about the mean trend and a characteristic period of 36 minutes. The optical degree of polarization jumped from $\sim3\%$ to nearly 20\% during the outburst, while the position angle varied by \sim120\degr. A knot was ejected from the 43 GHz core on 2016 Feb 25, moving at an apparent speed $v_\mathrm{app}=20.3c\pm0.8c$. From the observed minimum timescale of variability $\tau_\mathrm{opt}^\mathrm{min}\approx2$ hr and derived Doppler factor $\delta=22.6$, we find a size of the emission region $r\lesssim2.6\times10^{15}$ cm. If the quasi-periodic micro-variability oscillations are caused by periodic variations of the Doppler factor of emission from a turbulent vortex, we derive a rotational speed of the vortex $\sim0.2c$.Comment: 19 pages, 13 figures, 3 tables, accepted to the Astrophysical Journal 2019 March

Effects of stellar-mass primordial black holes on first star formation

We use cosmological hydrodynamic zoom-in simulations and semi-analytical models to study the effects of primordial black holes (PBHs) on first star formation. Our models self-consistently combine two competing effects: initial (isocurvature) perturbations induced by PBHs and BH accretion feedback. Focusing on PBHs with masses $\sim 30\ \rm M_{\odot}$, we find that the standard picture of first star formation in molecular-cooling minihaloes is not changed by PBHs, as the simulated star-forming gas clouds in the central parsec are very similar to those in the $\rm \Lambda CDM$ case when PBHs make up $f_{\rm PBH}\sim 10^{-4}-0.1$ of dark matter. With a dynamical friction timescale of $\sim 2-10\ \rm Myr$ when the central gas density reaches $10^{5}\ \rm cm^{-3}$, it is also unlikely that PBHs can sink into star-forming discs and affect the evolution of protostars, although they may interact with the stars during the main-sequence stage. At larger scales, PBHs tend to shift star formation to more massive haloes, and accelerate structure formation. The latter effect is stronger in regions with higher initial overdensities. For$f_{\rm PBH}\sim 10^{-4}-0.01$(allowed by observational constraints), the collapsed mass fraction of haloes hosting Population III stars is similar (within a factor of$\sim2$at$z\lesssim 30$) to that in$\rm \Lambda CDM$, implying that the impact of stellar-mass PBHs on the cosmic star formation history at$z\gtrsim 10$ is small. We also find that the Lyman-Werner photons from PBH accretion in atomic-cooling haloes may facilitate the formation of direct-collapse BHs.Comment: 23 pages, 18+3 figures, accepted by MNRAS, recognized Virgo and KAGRA in the LIGO-Virgo-KAGRA Scientific Collaboratio

Detectability of Supermassive Dark Stars with the Roman Space Telescope

Supermassive dark stars (SMDS) are luminous stellar objects formed in the early Universe at redshift z ∼ 10–20, made primarily of hydrogen and helium, yet powered by dark matter. We examine the capabilities of the Roman Space Telescope (RST), and find it able to identify ∼10 ^6 M _⊙ SMDSs at redshifts up to z ≃ 14. With a gravitational lensing factor of μ ∼ 100, RST could identify SMDS as small as ∼10 ^4 M _⊙ at z ∼ 12 with ∼10 ^6 s exposure. Differentiating SMDSs from early galaxies containing zero metallicity stars at similar redshifts requires spectral, photometric, and morphological comparisons. With only RST, the differentiation of SMDS, particularly those formed via adiabatic contraction with M ≳ 10 ^5 M _⊙ and lensed by μ ≳ 100, is possible due to their distinct photometric signatures from the first galaxies. Those formed via dark matter capture can be differentiated only by image morphology: i.e., point object (SMDSs) versus extended object (sufficiently magnified galaxies). By additionally employing James Webb Space Telescope (JWST) spectroscopy, we can identify the He ii λ 1640 absorption line, a smoking gun for SMDS detection. Although RST does not cover the required wavelength band (for z _emi ≳ 10), JWST does; hence, the two can be used in tandem to identify SMDS. The detection of SMDS would confirm a new type of star powered by dark matter and may shed light on the origins of the supermassive black holes powering bright quasars observed at z ≳ 6

How Do Primordial Black Holes Change the Halo Mass Function and Structure?

Abstract We examine the effects of massive primordial black holes (PBHs) on cosmic structure formation, employing both a semianalytical approach and cosmological simulations. Our simulations incorporate PBHs with a monochromatic mass distribution centered around 106 M ⊙, constituting a fraction of 10−2 to 10−4 of the dark matter (DM) in the Universe, with the remainder being collisionless particle DM. Additionally, we conduct a ΛCDM simulation for comparative analysis with runs that include PBHs. At smaller scales, halos containing PBHs exhibit similar density and velocity dispersion profiles to those without PBHs. Conversely, at larger scales, PBHs can expedite the formation of massive halos and reside at their centers owing to the “seed effect.” To analyze the relative distribution of PBH host halos compared to non-PBH halos, we apply nearest neighbor statistics. Our results suggest that PBH host halos, through gravitational influence, significantly impact the structure formation process, compared to the ΛCDM case, by attracting and engulfing nearby newly formed minihalos. Should PBHs constitute a fraction of DM significantly larger than ∼10−3, almost all newly formed halos will be absorbed by PBH-seeded halos. Consequently, our simulations predict a bimodal feature in the halo mass function, with most of the massive halos containing at least one PBH at their core and the rest being less massive non-PBH halos.</jats:p

Molecular targeted approaches to cancer therapy and prevention using chalcones.

There is an emerging paradigm shift in oncology that seeks to emphasize molecularly targeted approaches for cancer prevention and therapy. Chalcones (1,3-diphenyl-2-propen-1-ones), naturally-occurring compounds with widespread distribution in spices, tea, beer, fruits and vegetables, consist of open-chain flavonoids in which the two aromatic rings are joined by a three-carbon α, β-unsaturated carbonyl system. Due to their structural diversity, relative ease of chemical manipulation and reaction of α, β-unsaturated carbonyl moiety with cysteine residues in proteins, some lead chalcones from both natural products and synthesis have been identified in a variety of screening assays for modulating important pathways or molecular targets in cancers. These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-γ and β-catenin/Wnt. Compared to current cancer targeted therapeutic drugs, chalcones have the advantages of being inexpensive, easily available and less toxic; the ease of synthesis of chalcones from substituted benzaldehydes and acetophenones also makes them an attractive drug scaffold. Therefore, this review is focused on molecular targets of chalcones and their potential implications in cancer prevention and therapy