Factors influencing progression rate in higher education in Oman-data engineering and statistical approach

The paper highlights key issues in student progression in a tertiary level educational system. The colleges operate under the ministry of higher education, ministry of men power. Private universities are affiliated with the external universities from the developed world. Students come from various backgrounds and allocation of students to the education system depends on the performance of the student in the school. The good students get placed in state universities and colleges and those who could not get in the state universities get placed in private universities and colleges. Progression rates in all the type of system is a challenge. We have addressed a way to overcome this problem in this paper. An attempt is made to analyze the factors influencing progression rate in higher education system via data engineering and statistical approach

Association of Nutritional Status with Failure to Complete Planned Treatment in patients with HNSCC- a prospective cohort study in a Tertiary cancer centre in Northern India.

Background: To determine the association between Nutritional status of patient and the ability to complete all planned treatment in Head & Neck Squamous Cell Carcinoma(HNSCC). Materials & Methods: This prospective cohort study was conducted at CRI India between 2018 and 2020. Patients diagnosed with HNSCC and planned for treatment were enrolled after written informed consent. Nutritional status was determined using- anthropometric measures and Subjective Global Assessment(SGA) scale before starting treatment. Patients were followed up for treatment details, complications and failure to complete planned treatment. Statistical analysis was performed using SPSS version 22. Data was analyzed using parametric and non-parametric tests, p value of 0.05 was considered significant. Results: Total 161 patients were analyzed, mean age 56.3yr (±13.27 SD), 88.2% male, 64% cT3/4 stage, 91.9% ECOG PS 0 to 2. The age, gender, PS, subsite, stage, grade were not significantly associated with failure to complete planned treatment. Mean weight was 51.76 (±12.52 SD), 58.65 (±11.3 SD) kg (p=0.012), mean Body Mass Index(BMI) 19.36 (±4.3 SD), 21.92 (±4.09 SD) (p=0.009), median weight loss within 6months 11%, 3% (p=0.01), median SGA score 49, 38 (p=0.000) in patients who failed to complete treatment and who completed treatment. Percentage failure to complete treatment was 20%, 10.34% patients with weight ≤50kg, \u3e50kg (p=0.12, RR=2.17); 28.95%, 8.2% with BMI21cm (p=0.008, RR=5.2), 7.06%, 19.74% with SGA score Conclusions: Nutritional parameters like weight, BMI, MUAC, weight loss in 6 months, and SGA score are significantly associated with failure to complete treatment. Disparities in nutritional status of patients undergoing treatment for HNSCC need to be acknowledged

A Novel Method of Butterfly Optimization Algorithm for Load Balancing in Cloud Computing

Cloud computing is frequently alluded to as a model that furnishes boundless information handling conveniences with a compensation for each utilization framework. Present day cloud foundations resources as virtual machines (VMs) to actual machines utilizing virtualization innovation. All VMs works their involved structure and exhaust resources from their actual machine which behaves like a host. For load adjusting, Cloud moves VMs from exceptionally troubled real machines to low troubled actual machines. The delay of this calculation expansions in the organization as virtual machines are relocated. This work puts forward a new algorithm, namely Butterfly optimization for VM migration. The proposed optimization algorithm has been implemented in the MATLAB software.  A comparative analysis is performed between the outcomes of the preceding and the new algorithm.  The proposed algorithm has been evaluated over three performance parameters including delay, bandwidth used, and space used

Cluster Head Selection in a Homogeneous Wireless Sensor Network Ensuring Full Connectivity with Minimum Isolated Nodes

The research work proposes a cluster head selection algorithm for a wireless sensor network. A node can be a cluster head if it is connected to at least one unique neighbor node where the unique neighbor is the one that is not connected to any other node. If there is no connected unique node then the CH is selected on the basis of residual energy and the number of neighbor nodes. With the increase in number of clusters, the processing energy of the network increases; hence, this algorithm proposes minimum number of clusters which further leads to increased network lifetime. The major novel contribution of the proposed work is an algorithm that ensures a completely connected network with minimum number of isolated nodes. An isolated node will remain only if it is not within the transmission range of any other node. With the maximum connectivity, the coverage of the network is automatically maximized. The superiority of the proposed design is verified by simulation results done in MATLAB, where it clearly depicts that the total numbers of rounds before the network dies out are maximum compared to other existing protocols

Definitive chemoradiation in non metastatic squamous cell carcinoma anal canal: a single institution experience

Background: To analyze the oncological outcomes in anal canal squamous cell carcinoma treated with concurrent chemoradiotherapy. Materials and Methods: A single centre retrospective hospital based study with sample size of 51 patients of anal canal Squamous cell carcinoma treated with concurrent chemoradiotherapy with mitomycin @10mg/m2 and 5FU based. Disease free survival (DFS), Colostomy free survival (CFS) and Overall survival (OS) rates were calculated by Kaplan-Meier method. Results: Among 51 eligible patients, after a median follow up of 46 months (range 10-68 months). The 3year Disease free survival (DFS) was 73.9%. 3patients developed locoregional recurrence while 1patient developed distant metastasis. At 3 years Overall survival (OS) rate was 77%. Out of 44 patients 6 patients lost to follow up while 2 patients died due to progressive disease and 2 due to non cancer causes. 3year Colostomy free survival (CFS) rate was 59%. Total 18 out of 44 patients underwent colostomy. No grade 3 or 4 late toxicities occurred after completion of treatment. Conclusion: This study concluded that definitive chemoradiotherapy achieves good local control, overall survival and colostomy free survival with acceptable toxicity and can be recommended as standard treatment in patients with carcinoma anal canal

Dosimetric study for mastectomy carcinoma left breast cases with volumetric modulated arc therapy (VMAT)

Background: Radiation therapy for breast cancer has evolved from conventional to 3-dimentional radiation therapy (3-DCRT) and through more precise IMRT and VMAT. 3-DCRT is preferred for ca breast treatment as it reduces low dose area in contra lateral lung but with the advances in radiotherapy image guided techniques can deliver precise and lower doses to OARs with better coverage. This study is aimed to evaluate the doses of PTV, heart and ipsi-lateral lung with contra lateral lung doses delivered by VMAT technique. Method and material: Total 10 patients of carcinoma left breast with mastectomy were selected for VMAT planning with prescription of 45 Gy/20#. Eclipse 16.1 treatment planning system was used and treatment was delivered by True Beam with 6 MV photon energy with image guidance. The VMAT technique includes the non-continuous partial arc and continuous partial arc to deliver the dose. Dose volume histogram (DVH) was used to analyze for doses of planning target volume (PTV) and organs at risk (OARs). Results: PTV was covered with average 94.96% of prescribed dose. The average homogeneity index was found 0.02 and average conformity index was found 0.97 for VMAT plans. Mean doses for heart were measured 14.49±2.11Gy and for V25Gy 11.16±1.97Gy. Ipsilateral lung mean doses were observed 16.23±1.01 Gy, V20Gy doses were 28.73±1.52Gy, V30Gy doses were 14.78±2.5Gy and V40Gy doses were 5.59±1.98Gy. The contralateral lung mean doses were reported 7.69±1.79Gy and V10Gy 19.05±2.05Gy. Average planning target volume was 1710.98cc. The average homogeneity index was 0.02 and conformity index was 0.96. Conclusion: OARs doses with the use of VMAT with continuous and partial arcs are within limit and PTV coverage was also satisfactory. The contralateral lung doses were also within limit. For more precise treatment and low doses of heart and contra lateral lung VMAT technique can be preferred for carcinoma left breast treatment

Delineation of pathogenomic insights of breast cancer in young women

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The prognosis of breast cancer (BC) in young women (BCYW) aged ≤40 years tends to be poorer than that in older patients due to aggressive phenotypes, late diagnosis, distinct biologic, and poorly understood genomic features of BCYW. Considering the estimated predisposition of only approximately 15% of the BC population to BC-promoting genes, the underlying reasons for an increased occurrence of BCYW, at large, cannot be completely explained based on general risk factors for BC. This underscores the need for the development of next-generation of tissue- and body fluid-based prognostic and predictive biomarkers for BCYW. Here, we identified the genes associated with BCYW with a particular focus on the age, intrinsic BC subtypes, matched normal or normal breast tissues, and BC laterality. In young women with BC, we observed dysregulation of age-associated cancer-relevant gene sets in both cancer and normal breast tissues, sub-sets of which substantially affected the overall survival (OS) or relapse-free survival (RFS) of patients with BC and exhibited statically significant correlations with several gene modules associated with cellular processes such as the stroma, immune responses, mitotic progression, early response, and steroid responses. For example, high expression of COL1A2, COL5A2, COL5A1, NPY1R, and KIAA1644 mRNAs in the BC and normal breast tissues from young women correlated with a substantial reduction in the OS and RFS of BC patients with increased levels of these exemplified genes. Many of the genes upregulated in BCYW were overexpressed or underexpressed in normal breast tissues, which might provide clues regarding the potential involvement of such genes in the development of BC later in life. Many of BCYW-associated gene products were also found in the extracellular microvesicles/exosomes secreted from breast and other cancer cell-types as well as in body fluids such as urine, saliva, breast milk, and plasma, raising the possibility of using such approaches in the development of non-invasive, predictive and prognostic biomarkers. In conclusion, the findings of this study delineated the pathogenomics of BCYW, providing clues for future exploration of the potential predictive and prognostic importance of candidate BCYW molecules and research strategies as well as a rationale to undertake a prospective clinical study to examine some of testable hypotheses presented here. In addition, the results presented here provide a framework to bring out the importance of geographical disparities, to overcome the current bottlenecks in BCYW, and to make the next quantum leap for sporadic BCYW research and treatment.info:eu-repo/semantics/publishedVersio

Influence of integrated nutrient management on physiological parameters of lentil (Lens culinaris Medik.)

During the rabi season of 2021, a field experiment was conducted in the North Western plains of Uttarakhand at Crop Research Centre, School of Agriculture, Uttaranchal University, Dehradun to examine the impact of integrated nutrient management (INM) on lentil growth, yield, and economics (Lens culinaris Medik.). The experiment was laid in Randomized Block Design with seven treatments i.e. T1 (Control, 100% RDF (Recommended Dose of Fertilizers), T2 (75 % NPK (Nitrogen, Phosphorus, Potassium) + 25 % FYM (Farm Yard Manure), T3 (50 % NPK + 50 % FYM), T4 (75 % NPK + 25 % Azotobacter), T5 (50 % NPK + 50 % Azotobacter), T6 (75 % NPK + 25 % (Vermicompost + Azotobacter)) & T7 (50 % NPK+ 50 % (Vermicompost + Azotobacter)). The treatments T7 with the combination of 50 per cent NPK and 50 per cent vermicompost plus Azotobacter showed maximum LAI (Leaf Area Index) (0.25), NAR (Net Assimilation Rate) (0.0020), chlorophyll content (3.05), dry matter (4.44 g), and protein content (26.99 %) in contrast to other six treatments

Dosimetric and volumetric analysis in endobronchial brachytherapy treatment of carcinoma lung patients: A pilot study

Background: To analyze the radiation doses received by Organ at Risk (OAR) nearby the target volume and volumetric changes in the target volume in carcinoma lung patients irradiated in three treatment session of endobronchial brachytherapy (EBBT). Methods: Dosimetric analysis was conducted on patients of carcinoma Lung received three session of Endobronchial brachytherapy treatment in High Dose Rate brachytherapy unit with Ir-192 source. A flexible Lumencare catheter was inserted into the bronchus and positioned catheter tip at the tumor. Length of the implanted catheter was measured with the source position simulator device. Acquired three dimensional CT image data set with x-ray marker was sent to TPS to generate an optimized treatment plan. The OAR’s and target volume were delineated for the accurate assessment of doses in each brachytherapy treatment session. The prescribed dose was normalization at 1.0cm from the center of the catheter. Doses to OAR’s and target volume were noted down from the DVH and detailed dose volume table from TPS. The prescribed dose was 7Gy per fraction in three fractions. Doses to OAR’s and Target volumes were also evaluated for each treatment session of the patient. The change in the volume of the target irradiated was noted down from the dose volume table in TPS. Results: Thirty sessions were evaluated in this study as these were infrequent procedures to perform. Average mean dose to Esophagus was varied from 1.18Grey to 0.85Grey, average maximum dose to Heart was varied from 4.77Grey to 3.69Grey and average maximum dose to left coronary artery was varied from 0.44Grey to 0.91Grey. Average changes in the volume of a Target volume was found in varied from 20.45cc to 13.70cc in each treatment session and found there is signification volume reduction in the target volume irradiated. Conclusion: This study showed that the doses to OARs are significantly increased in second and third session of EBBT and the doses to OAR’s were in their tolerance limit. There is a significant volume reduction in volume of the target in second and third treatment EBBT session. It implies that the EBBT is much effective in the treatment of lung carcinoma patients having disease lesion in primary and secondary bronchus

Clinical profile of dengue fever infection in patients admitted in tertiary care centre Agroha, Hisar, Haryana, India

Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at MAMC.Methods: This retrospective study included 188 patients infected with dengue virus, age 6 years to 70 years. Laboratory and haematological data were included.Results: Peak of infection occurred in October 2015 and least number of cases were recorded in December 2015. Common clinical symptoms were fever, and abdominal pain. Common haematological abnormalities were thrombocytopenia and leucopoenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations