4 research outputs found
A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make
Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased
our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient with POMC
deficiency due to a homozygous c.206delC mutation in the POMC gene. We discuss the pathogenesis of this condition with emphasis
on the crosstalk between hypothalamic and peripheral signals in the development of obesity and the POMC-melanocortin 4 receptors
system as a target for therapeutic intervention
Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional study
Aims To describe the baseline clinical and laboratory findings and treatment modalities of 367 children and adolescents diagnosed with Type 2 diabetes in various paediatric endocrinology centres in Turkey. Methods A standard questionnaire regarding clinical and laboratory characteristics at onset was uploaded to an online national database system. Data for 367 children (aged 6-18 years) newly diagnosed with Type 2 diabetes at 37 different paediatric endocrinology centres were analysed. Results After exclusion of the children with a BMI Z-score 50% of the children were asymptomatic at diagnosis. The other important result of our study was the high rate of exclusion from the initial registration (38%), suggesting that accurate diagnosis of Type 2 diabetes in youth is still problematic, even for paediatric endocrinologists
Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional study
Aims To describe the baseline clinical and laboratory findings and
treatment modalities of 367 children and adolescents diagnosed with Type
2 diabetes in various paediatric endocrinology centres in Turkey.
Methods A standard questionnaire regarding clinical and laboratory
characteristics at onset was uploaded to an online national database
system. Data for 367 children (aged 6-18 years) newly diagnosed with
Type 2 diabetes at 37 different paediatric endocrinology centres were
analysed. Results After exclusion of the children with a BMI Z-score < 1
SD, those with genetic syndromes associated with Type 2 diabetes, and
those whose C-peptide and/or insulin levels were not available, 227
cases were included in the study. Mean age was 13.8 +/- 2.2 (range
6.5-17.8) years, with female preponderance (68\%). Family history of
Type 2 diabetes was positive in 86\% of the children. The mean BMI was
31.3 +/- 6.5 kg/m(2) (range 18.7-61) and BMI Z-score was 2.4 +/- 0.8
(range 1-5). More than half (57\%) of the children were identified by an
opportunistic diabetes screening due to existing risk markers without
typical symptoms of diabetes. Only 13\% (n = 29) were treated solely by
lifestyle modification, while 40.5\% (n = 92) were treated with
metformin, 13\% (n = 30) were treated with insulin, and 33.5\% (n = 76)
were treated with a combination of insulin and metformin initially. Mean
HbA(1C) levels of the insulin and combination of insulin and metformin
groups were 98 (11.1\%) and 102 mmol/mol (11.5\%), respectively, and
also were significantly higher than the lifestyle modification only and
metformin groups mean HbA(1C) levels (70(8.6\%) and 67 mmol/mol (8.3\%),
respectively). Conclusions An opportunistic screening of children who
are at high risk of Type 2 diabetes is essential, as our data showed
that > 50\% of the children were asymptomatic at diagnosis. The other
important result of our study was the high rate of exclusion from the
initial registration (38\%), suggesting that accurate diagnosis of Type
2 diabetes in youth is still problematic, even for paediatric
endocrinologists