What Developments in Western Europe Tell Us About American Critiques of Corporate Criminal Liability

Although corporate criminal liability has been recognized in the United States for nearly a century, contemporary academic commentators have questioned its legitimacy and argued that it is inferior to its alternatives: civil liability for the corporation and/or criminal liability for individual corporate agents. Other academic critics have attacked the present definitions of corporate criminal liability. In other words, although corporate criminal liability has also had its academic champions, it has been under attack in the United States. The situation in Europe poses a sharp contrast

Growth Inhibition of Various Pathogenic Microorganisms Using Effective Microorganisms (EM)

In recent years, researchers focus on treatment of wastewater using low-cost treatment processes. Several studies showed that using effective microorganisms (EM) is a promising technology in the treatment of wastewater. However, the treatment mechanism using EM is not clear. In this study, the effect of EM towards several pathogenic microorganisms was investigated to examine its ability to inhibit their growth. The results showed that EM has the ability to inhibit the growth of pathogenic bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Streptococcus faecalis; while no effect was detected on fungi that were examined.  &nbsp

Adoption of Open Source and conventional ERP solutions for small and medium enterprises in manufacturing

Many studies on the Enterprise Resource Planning (ERP) market have indicated that very few ERPs have succeeded to fully meet the expectations of an organisation in particularly the Small and Medium Enterprises (SMEs). This is usually due to commercial reasons, because most of the ERP systems are primarily designed and developed for large corporations which is not suitable for simplified and rapidly changing SMEs. With the arrival of licence free open source ERPs and at an affordable price, the problem of capital shortage in SMEs is partially resolved while flexibility remains a problem. In order to solve the flexibility issue, this paper presents methods of (a) an industrial survey and (b) a multistage initiation model to compare open source ERPs and the advantages of conventional ERP’s modular structure to propose an alternative ERP platform. The finding concludes that this alternative platform is feasible to be developed by users as well as flexible enough for growing SMEs in manufacturing

Hair histology as a tool for forensic identification of some domestic animal species

Animal hair examination at a criminal scene may provide valuable information in forensic investigations. However, local reference databases for animal hair identification are rare. In the present study, we provide differential histological analysis of hair of some domestic animals in Upper Egypt. For this purpose, guard hair of large ruminants (buffalo, camel and cow), small ruminants (sheep and goat), equine (horse and donkey) and canine (dog and cat) were collected and comparative analysis was performed by light microscopy. Based on the hair cuticle scale pattern, type and diameter of the medulla, and the pigmentation, characteristic differential features of each animal species were identified. The cuticle scale pattern was imbricate in all tested animals except in donkey, in which coronal scales were identified. The cuticle scale margin type, shape and the distance in between were characteristic for each animal species. The hair medulla was continuous in most of the tested animal species with the exception of sheep, in which fragmental medulla was detected. The diameter of the hair medulla and the margins differ according to the animal species. Hair shaft pigmentation were not detected in all tested animals with the exception of camel and buffalo, in which granules and streak-like pigmentation were detected. In conclusion, the present study provides a first-step towards preparation of a complete local reference database for animal hair identification that can be used in forensic investigations.Comment: 8 pages, 3 Figure

Upgrading Conventional Activated Sludge System Using Bio-media: A Case Study of Zenin Wastewater Treatment Plant, Egypt

This study investigated the ability to upgrade the biological treatment system in Zenin wastewater treatment plant, in Egypt. This investigation was conducted through the comparison of three different biological treatment systems: activated sludge process (AS), moving bed biofilm reactor (MBBR), and integrated fixed film activated sludge system (IFAS). Three pilot systems were established at Zenin wastewater treatment plant, to simulate AS, MBBR, and IFAS systems, to show the effect of various parameters on the removal efficiencies of biochemical oxygen demand (BOD5), total suspended solids (TSS), and ammonium-nitrogen (NH4-N). Different values of hydraulic retention time, different amounts of returned sludge, and concentration of dissolved oxygen, were examined. The maximum removal efficiencies of BOD5, TSS, and NH4-N were 50%, 81.9%, and 82% in activated sludge system, respectively; 80%, 81.8%, and 99.3% in MBBR system, respectively; and 62.3%, 86.2%, and 76% in IFAS system, respectively. Keywords: Attached growth; Hybrid growth; Sludge; Suspended growth; Wastewater DOI: 10.7176/CER/11-1-0

A Novel Implementation of an Extended 8x8 Playfair Cipher Using Interweaving on DNA-encoded Data

Recentlty, cryptography makes extensive use of different fields includingbioinformatics. The fundamental idea behind the cipher presented here is to transform any kind of binary message; such as text, sound tracks, and even images, into the form of a single-stranded DNA sequence. Subsequently, digraphs of codon triplets are encrypted using a grid of 8x8 codon matrix that is randomly constructed according to some secret key. Although the encryption/decryption rules were kept almost the same as the classical 5x5 Playfair, using the DNA encoding step makes it almost impossible for an attacker to perform a frequency analysis on that vast number of character digraphs. Furthermore, an interweaving step is added to scramble the encrypted sequence offering more randomness. When compared with other modifications of the Playfair cipher, the proposed method showed a number of advantages including the ability to cipher any type of digital media, the elimination of plain-text preprocessing step, and the applicability to be integrated into larger security systems such as DNA steganography. Furthermore, due to the very weak correlation between cipher-data and original message, the proposed method shows a strong robustness against cipher attacks.DOI:http://dx.doi.org/10.11591/ijece.v4i1.496

Folate Nanoparticle Conjugates

The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate receptor positive cancer cells. In this review I will examine the current status and role of folate targeted nanoconjugates for both diagnostic imaging and therapy

Analysis of single-cell RNA-Seq reveals dynamic changes during macrophage state transition in atherosclerosis mouse model

Background: Atherosclerosis is an arterial inflammation that causes ischemic heart disease, which is the first leading cause of death worldwide. Macrophages play major roles during disease development by having pro-inflammatory and anti-inflammatory functions. Lack of effective treatment is mainly due to incomplete understanding of the molecular mechanisms underlying disease progression and regression. Materials and methods: The transcripts of the macrophages from two aortic samples from atherosclerotic region during disease progression and regression were analyzed using previously published dataset (GEO Accession GSE123587). Pre-processing, clustering of cells and identification of unique markers for each cluster were done using Seurat package implemented in R programming language. Monocle package was used to order the cells in pseudotime and to detect the key molecules that changed dramatically during comparison between distinct macrophages states (pro-inflammatory and anti-inflammatory). Ingenuity Pathway Analysis (IPA) software was used to analyze the pathways activity across macrophage states along the trajectory and to retrieve the transcriptional regulatory network between the genes determining the final states. Prediction of the miRNAs that might be involved in the disease progression was performed using TargetScan and GSEA (Gene Set Enrichment Analysis). Cytoscape application was used to visualize the regulatory network between the differentially regulated genes across macrophages states. Results: Clustering analysis of macrophages revealed their presence in distinct 11 states. In addition, Two states were found to be dominant in the progression group macrophages, and one state was found to be dominant in the regression group macrophages. Moreover, trajectory analysis showed a bifurcation point near the end of the trajectory, where macrophages fates were destined to be either pro-inflammatory or anti-inflammatory. Macrophages unique to the disease progression branch were found to activate STAT cascade, induce acute inflammatory response and upregulate inflammatory cytokines, denoting M1 polarization. In contrast, regression-branch specific macrophages were found to activate cholesterol efflux pathways and upregulate anti-inflammatory cytokines such as TSLP and CCL24. The transcription regulatory network between differentially regulated genes in both branches revealed changes in the transcriptional dynamics acquired during macrophage states transition. STAT1 (Signal transducer and activator of transcription 1) and IRF7 (Interferon Regulatory Factor 7) were found to be upregulated in the progression branch to maintain an inflammatory module resulting in production of distinct inflammatory cytokines. On the other hand, MAFB (MAF BZIP Transcription Factor B) and IGF1 (Insulin-like growth factor 1) were found to be upregulated in the regression branch to interrupt the inflammatory module at different levels. In addition, 10 miRNAs were predicted to be unregulated in progression-branch specific macrophages such as miR-344, miR-346 and miR-485. Conclusion: Inflammatory sites in atherosclerosis lesions contain both pro-inflammatory and anti-inflammatory macrophages. Each subset of macrophage activates unique transcriptional program. Certain transcription factors and growth factors have potential to alter the whole transcriptional regulatory network, thereby shifting the macrophages from inflammatory to anti-inflammatory state. Understanding how macrophage state transition occurs from inflammatory to anti-inflammatory state will be a key step to better understanding and treating atherosclerosis

Safety Culture of Companies in the Oil and Gas Industry

This project examines the factors that influence the safety culture in companies of the oil and gas industry. The project highlights and identifies the important factors that affect the safety culture in the oil and gas industry and based on the findings from past researches and a field study, a model of safety culture will be developed. The report explains in details the review of 48 literature and case studies that are related to the safety culture of companies in different industries but mainly from the oil and gas industry. The literature studied the factors that affect the safety culture and identified the factors that contributed to the occurrence of major accident