Cognitive symptoms associated with antipsychotic course experience in residual schizophrenia

Urgency. The cognitive symptoms of schizophrenia are recognized either as a part of a negative complex of symptomatic, where cognitive malfunction seem to be the secondary complication of emotional and motivational dysregulation; or as a separate group of schizophrenia manifestations that constitutes a massive part of a residual condition. Aim – to evaluate the cognitive functioning and analyze its violation levels in association with antipsychotic course experience in patients with residual schizophrenia. Results. The assessment of cognitive functions was established by direct testing in clinical setting. Education in years varied from 9 to 16, mean 11,27±2,12 in the population under study. The basic level of cognitive impairment was established: verbal memory test result was 31,6±11,6; digit sequencing test result was 13,4±5,7; token motor task test result was 40,1±18,3; verbal fluency test result was 41,2±10,7; symbol coding test result was 30,6±13,1; tower of london test result was 12,2±4,5. Some correlations were found: for chlorpromazine we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,27) results; for haloperidol we can assume more pronounced but still minor impact on token motor task (r= -0,22), verbal fluency test (r= -0,27), verbal memory test (r= -0,28) and tower of London test (r= -0,20) results; for trifluoperazine we can see minor negative impact on  verbal fluency test (r= -0,26); for clozapine we can’t find any representative correlations with cognitive tests; chlorprothixene as we can assume have minor negative impact on verbal memory test (r= -0,32) result, but minor positive – on tower of London test (r= 0,21) result; for risperidone also assume minor positive impact on sequence coding test (r= 0,25), but other tests in battery show no significant correlations; for zuclopenthixol we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,31) results.&nbsp

Synthetic cannabinoids induced psychotic episode as differential diagnostic challenge: clinical case

In order to highlight a problem of differential diagnostic of primal psychotic episode which induced by "smoking mixtures" intoxication, the case of a primary psychotic episode of schizophrenia due to the use of cannabinoids, which is primarily qualified as acute polymorphic psychotic disorder with symptoms of schizophrenia has been described. As a result, the issue of clinical differential diagnosis of the genesis of acute polymorphic psychotic disorder with symptoms of schizophrenia induced by synthetic cannabinoids was revealed

Variants and factors of catatonic syndrome pathomorphosis in the structure of endogenous catatonia

Urgency. Pathomorphosis of mental pathology leads to polymorphism or dissociation of its clinical manifestations, and, as a result, to difficulties in identification and differential diagnosis of individual psychopathological forms. Design. In order to establish the basic characteristics, variants and factors of the endogenic catatonia pathomorphism in schizophrenia patients, 144 individuals were examined. In the patients under examination the elements of endogenous catatonia were in the structure of various clinical forms of schizophrenia. Results. On the basis of a comparative analysis of the clinical and psychopathological characteristics of the catatonic syndrome in two ten - year periods pool of factors of endogenous catatonia pathomorphism, its structural and dynamic deviations were established. Conclusions. The main characteristics and tendencies of endogenous catatonia pathomorphism are determined. Four groups of catatonic syndrome pathomorphosis factors are identified and systematized: pharmacogenic, toxic, alternative, involutionary. Two vectors of pathomorphosis were systematized: functional (pharmacogenic and toxic groups) and morphological (alternative and involutionary groups)

Comparison of basic neurocognitive violations in patients with residual schizophrenia with and without history of ischemic stroke

Relevance. The cognitive symptoms associated with schizophrenia have been a subject of controversy and are often viewed through a dualistic lens. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), these cognitive symptoms can be further elucidated within specific neurocognitive domains. Many of the symptoms of schizophrenia manifest behaviorally and can be challenging to differentiate from the consequences of organic brain impairment, especially when these symptoms involve the frontal and temporal cortex or have a diffuse presentation. Aim – to evaluate neurocognitive deficit in patients with residual schizophrenia with history of ischemic stroke. Materials and methods. A comprehensive study was conducted involving 100 patients diagnosed with recurrent schizophrenia (ICD-10: F20.5) at the Communal Non-Profit Enterprise "Regional Clinical Institution for the Provision of Psychiatric Care". We selected 59 patients: 32 patients with residual schizophrenia without history of stroke (Group 1, G1) and 27 patients with residual schizophrenia with history of stroke (Group 2, G2). Neuropsychological testing was used to evaluate neurocognitive violations. Due to massive distortions that brought to testing results by schizophrenia negative symptoms, only general evaluation was made to reflect critical or non-critical to no violations in separate functions. Statistical method of chi-square test was used to compare results in groups.  Study results. To compare neurocognitive violations in G1 and G2 we performed neuropsychological testing in basic neurocognitive domains. G2 patients, diagnosed with both schizophrenia and a stroke, generally exhibit heightened cognitive impairments compared to G1 patients with only schizophrenia. Notably, deficits in Sustained Attention, Divided Attention, Processing Speed, Working Memory, Mental Flexibility, immediate memory, implicit learning, and both expressive and receptive language are more pronounced in G2 patients. However, for functions like Selective Attention, Planning, Decision-Making, recent and very-long-term memory, and interpersonal understanding, the added influence of a stroke in G2 doesn't drastically differentiate them from G1. In essence, while schizophrenia inherently poses cognitive challenges, the co-occurrence of a stroke amplifies certain deficits but not others. This data suggests a complex interplay between schizophrenia and stroke in influencing cognitive function. Conclusions. The coexistence of schizophrenia and a history of stroke in G2 patients frequently exacerbates certain cognitive impairments when compared to those diagnosed solely with schizophrenia. This underlines the compounded cognitive challenges faced by patients with comorbid conditions. However, for some cognitive domains, the severity of impairments is primarily governed by schizophrenia, irrespective of the presence of an additional stroke history. This comprehensive analysis underscores the complex interplay of multiple conditions on cognitive function and emphasizes the importance of individualized care and intervention strategies tailored to the specific cognitive challenges faced by each patient group

Preclinical differential diagnostics of anorexia nervosa and dissociative food refusal: the rating scale

In order to develop the rating scale for preclinical differential diagnostics of anorexia nervosa and dissociative food refusal, a retrospective study of two groups of patients with established diagnoses of anorexia nervosa (21 patients) and «mixed (conversion) dissociative disorder» with refusal to eat (23 female patients) were examined. As a result, the express-test for the differential diagnosis of anorexia nervosa and dissociative disorders with the refusal of food was developed, it can be used in the first contact of the patient and the doctor

Hyperfine frequency shift in two-dimensional atomic hydrogen

We propose the explanation of a surprisingly small hyperfine frequency shift in the two-dimensional (2D) atomic hydrogen bound to the surface of superfluid helium below 0.1 K. Owing to the symmetry considerations, the microwave-induced triplet-singlet transitions of atomic pairs in the fully spin-polarized sample are forbidden. The apparent nonzero shift is associated with the density-dependent wall shift of the hyperfine constant and the pressure shift due to the presence of H atoms in the hyperfine state $a$ not involved in the observed $b\to c$ transition. The interaction of adsorbed atoms with one another effectively decreases the binding energy and, consequently, the wall shift by the amount proportional to their density. The pressure shift of the $b\to c$ resonance comes from the fact that the impurity $a$-state atoms interact differently with the initial $b$-state and final $c$-state atoms and is also linear in density. The net effect of the two contributions, both specific for 2D hydrogen, is comparable with the experimental observation. To our knowledge, this is the first mentioning of the density-dependent wall shift. We also show that the difference between the triplet and singlet scattering lengths of H atoms, $a_t-a_s=30(5)$ pm, is exactly twice smaller than the value reported by Ahokas {\it et al.}, Phys. Rev. Lett. {\bf101}, 263003 (2008).Comment: 4 pages, no figure

Metallic and insulating behaviour of the two-dimensional electron gas on a vicinal surface of Si MOSFETs

The resistance R of the 2DEG on the vicinal Si surface shows an unusual behaviour, which is very different from that in the (100) Si MOSFET where an unconventional metal to insulator transition has been reported. The crossover from the insulator with dR/dT0 occurs at a low resistance of R_{\Box}^c \sim 0.04h/e^2. At the low-temperature transition, which we attribute to the existence of a narrow impurity band at the interface, a distinct hysteresis in the resistance is detected. At higher temperatures, another change in the sign of dR/dT is seen and related to the crossover from the degenerate to non-degenerate 2DEG.Comment: 4 pages, 4 figure

Fluctuation-dissipation considerations and damping models for ferromagnetic materials

The role of fluctuation-dissipation relations (theorems) for the magnetization dynamics with Landau-Lifshitz-Gilbert and Bloch-Bloembergen damping terms are discussed. We demonstrate that the use of the Callen-Welton fluctuation-dissipation theorem that was proven for Hamiltonian systems can give an inconsistent result for magnetic systems with dissipation