Electrophilicity of neutral square-planar organosilver(III) compounds

Neutral Ag(III) complexes stabilised with just monodentate ligands are here unambiguously established. In a series of square-planar (CF3)3Ag(L) compounds with hard and soft Group 15 donor ligands, L, the metal center has been found to exhibit substantial acidity favouring apical coordination of an additional ligand under no coordination constraints

1-(12-Azido-n-dodecyl)-4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetrahydro-1 H-1,5-benzodiazepin-3-yl)methyl]-1H-1,2,3-triazole

The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with 1,12-diazido-n-dodecane in the presence of catalysts leads to the formation of the title compound, C(38)H(46)N(8)O(2). The seven-membered diazepinyl ring adopts a boat conformation with the azidododecyltriazolylmethyl-bearing C atom as the prow and the fused-ring C atoms as the stern. The octyltriazolylmethyl substituent occupies an axial position

1-Arsa-3-germaallene tip(t-Bu)Ge=C=AsMes*: The heaviest mixed group 14 and 15 heteroallenic compound

cited By 8International audienceThe 1-arsa-3-germaallene Tip(t-Bu)Ge=C=AsMes* (1, Tip = 2,4,6-triisopropylphenyl, Mes* = 2,4,6-tri-tert-butylphenyl), a stable heavier group 14 and 15 congener of allenes, has been synthesized by debromofluorination of Tip(t-Bu)Ge(F)-C(Br)=AsMes. It reacts with methanol and 2,3-dimethyl-1,3-butadiene by the Ge=C double bond. The allenic-type structure of 1, featuring cumulated Ge=C and C=As double bonds, has been evidenced by means of spectroscopic and single-crystal X-ray determination. The electronic properties involved in this new system were obtained from DFT calculations. The mechanism of the reaction between 1 and the dimethylbutadiene is also described to understand the observed regio- and chemoselectivity. © 2011 American Chemical Society

Copper(I) complexes derived from mono- and diphosphino-boranes: Cu→b interactions supported by arene coordination

cited By 66International audienceThe monophosphino-boranes o-iPr2P(C6H 4)BR2 (1: R = Ph and 3: R = Cy) and diphosphino-boranes [o-R2P(C6H4)]2BPh (5: R = Ph and 6: R = iPr) readily react with CuCl to afford the corresponding complexes [o-iPr2P(C6H4)BPh2]Cu(μ-Cl) 2 2, [o-iPr2P(C6H4)BCy 2]Cu(μ-Cl)2 4, [o-Ph2P(C6H 4)]2BPhCuCl 7, and [o-iPr2P(C 6H4)]2BPhCuCl 8. The presence of Cu→B interactions supported by arene coordination within complexes 2, 7, and 8 has been unambiguously evidenced by NMR spectroscopy and X-ray diffraction studies. The unique η2-BC coordination mode adopted by complexes 7 and 8 has been thoroughly analyzed by density-functional theory (DFT) calculations. © 2009 American Chemical Society

Synthesis and evaluation of α-ketotriazoles and α,β-diketotriazoles as inhibitors of Mycobacterium tuberculosis

Two series of α-ketotriazole and α,β-diketotriazole derivatives were synthesized and evaluated for antitubercular and cytotoxic activities. Among them, two α,β-diketotriazole compounds, 6b and 9b, exhibited good activities (minimum inhibitory concentration = 7.6 μM and 6.9 μM, respectively) on Mycobacterium tuberculosis and multi-drug resistant M. tuberculosis strains and presented no cytotoxicity (IC50 > 50 μM) on colorectal cancer HCT116 and normal fibroblast GM637H cell lines. These two compounds represent promising leads for further optimization

A Significant but Constrained Geometry Pt→Al Interaction: Fixation of CO2 and CS2, Activation of H2 and PhCONH2

International audienc

Group 10 and 11 metal boratranes (Ni, Pd, Pt, CuCl, AgCl, AuCl, and Au +) derived from a triphosphine-borane

cited By 128International audienceThe ambiphilic triphosphine-borane ligand 1 TPB = [o-iPr 2P-(C6H4)]3B readily coordinates to all group 10 and 11 metals to afford a complete series of metal boratranes (TPB)[M] 2-8 (2: M = Ni, 3: M = Pd, 4: M = Pt, 5: M = CuCl, 6: M = AgCl, 7: M = AuCl, 8: M = Au+). Spectroscopic and structural characterization unambiguously establishes the presence of M→B interactions in all of these complexes. The first evidence for borane coordination to copper and silver is provided, and the Au→B interaction is shown to persist upon chloride abstraction. Experimental and theoretical considerations indicate that the M→B interaction is strongest in the Pt and Au complexes. The influence of the oxidation state and charge of the metal is substantiated, and the consequences of relativistic effects are discussed. The coordination of the σ-acceptor borane ligand is found to induce a significant bathochromic shift of the UV-vis spectra, the Ni, Pd, and Pt complex presenting strong absorptions in the visible range. In addition, all of the group 10 and 11 metal boratranes adopt C3 symmetry both in the solid state and in solution. The central M→B interaction is found to moderately influence the degree of helicity and configurational stability of these three-bladed propellers, and DFT calculations support a dissociative pathway for the inversion process. © 2008 American Chemical Society