Analyzing the Structure of Administrative System of Hormozgan and its Adaptation to the Perspective of 1404 with the Land Use Planning Approach

The present study aimed to analyze the structure of administrative systems in Hormozgan and its adaptation to the 1404 perspective with the land use planning (land preparation) approach. This paper is applied in purpose and is descriptive-analytical in nature. The statistical population of this research is Hormozgan as one of the Iran provinces. In order to collect information on the theoretical foundations and research literature, library resources, articles and required books were used and indicators of the administrative system structures (staff, development budget, planning system, spatial structure and free zones) were identified. The required quantitative data was extracted and classified based on census and housing results during 2006- 2017 and after quantitative calculations, they were analyzed in order to adjust with the 1404 goals. In order to analyze the information, time series and factor analysis methods and central tendencies and dispersion were used. SPSS version 24, MINTAB version 17, AMOS version 24 and excel were used for data analysis. Based on the results, considering that there was a significant difference between the value of the mean calculated for each of the factors of the administrative system structure during 2006-2017 (the current administrative system of Hormozgan) and the values related to the administrative system of perspective 1404, so it can be said that there is a difference between the current administrative system of Hormozgan and the perspective of 1404 with the land use planning approach

Analyzing the Structure of Administrative System of Hormozgan and its Adaptation to the Perspective of 1404 with the Land Use Planning Approach

The present study aimed to analyze the structure of administrative systems in Hormozgan and its adaptation to the 1404 perspective with the land use planning (land preparation) approach. This paper is applied in purpose and is descriptive-analytical in nature. The statistical population of this research is Hormozgan as one of the Iran provinces. In order to collect information on the theoretical foundations and research literature, library resources, articles and required books were used and indicators of the administrative system structures (staff, development budget, planning system, spatial structure and free zones) were identified. The required quantitative data was extracted and classified based on census and housing results during 2006- 2017 and after quantitative calculations, they were analyzed in order to adjust with the 1404 goals. In order to analyze the information, time series and factor analysis methods and central tendencies and dispersion were used. SPSS version 24, MINTAB version 17, AMOS version 24 and excel were used for data analysis. Based on the results, considering that there was a significant difference between the value of the mean calculated for each of the factors of the administrative system structure during 2006-2017 (the current administrative system of Hormozgan) and the values related to the administrative system of perspective 1404, so it can be said that there is a difference between the current administrative system of Hormozgan and the perspective of 1404 with the land use planning approach.El presente estudio tuvo como objetivo analizar la estructura de los sistemas administrativos en Hormozgan y su adaptación a la perspectiva 1404 con el enfoque de planificación del uso del suelo (preparación del suelo). Este artículo se aplica con un propósito y es de naturaleza descriptiva-analítica. La población estadística de esta investigación es Hormozgan como una de las provincias de Irán. Para recopilar información sobre los fundamentos teóricos y la literatura de investigación, se utilizaron recursos bibliotecarios, artículos y libros requeridos y se identificaron indicadores de las estructuras del sistema administrativo (personal, presupuesto de desarrollo, sistema de planificación, estructura espacial y zonas francas). Los datos cuantitativos requeridos se extrajeron y clasificaron con base en los resultados del censo y vivienda durante el período 2006-2017 y luego de cálculos cuantitativos, se analizaron para ajustarlos con las metas 1404. Para el análisis de la información se utilizaron métodos de análisis factorial y de series de tiempo y tendencias centrales y dispersión. Para el análisis de datos se utilizaron SPSS versión 24, MINTAB versión 17, AMOS versión 24 y Excel. Con base en los resultados, considerando que hubo una diferencia significativa entre el valor de la media calculada para cada uno de los factores de la estructura del sistema administrativo durante el período 2006-2017 (el actual sistema administrativo de Hormozgan) y los valores relacionados con el sistema administrativo de perspectiva 1404, por lo que se puede decir que existe una diferencia entre el sistema administrativo actual de Hormozgan y la perspectiva de 1404 con el enfoque de ordenamiento territorial

Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat

Ulcerative colitis is a chronic inflammatory condition of the colon with an unknown etiology. In this study, we aimed to evaluate the therapeutic effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. Fifty-five male rats divided into five equal treatment groups were used for this study and received the following treatments: Group 1, 250 mg/kg asacol; Group 2, 1 ml gel base (carboxymethyl cellulose); Group 3, 0.5% gel form of C. sempervirens extract; Group 4, 1% gel form of C. sempervirens extract, and; Group 5, considered as negative control and received 1 ml of normal saline. Body weight changes, histopathological and antioxidant changes in the colon tissue were evaluated. Significant weight gain was observed in rats that received 1% gel extract of C. sempervirens. Significant superoxide dismutase activity was also detected in 0.5 and 1% gel extract groups compared to C. sempervirens extract, Asacol and in 1% gel extract groups compared to the gel base group. Furthermore, both gel extract groups had significant lower total antioxidant capacity compared to Asacol group. Several histopathological lesions including inflammation, ulceration, crypt disarray, and goblet cell depletion were detected in the different groups, however, the mean rank of pathological changes showed no significant difference among the five groups. In summary, our results showed that hydroalcoholic extracts of C. sempervirens leaves produces healing effects in acetic acid induced ulcerative colitis. Resumo: A colite ulcerativa é uma doença inflamatória crônica do cólon com uma etiologia desconhecida. O objetivo deste estudo foi avaliar os efeitos terapêuticos do extrato de Cupressus sempervirens na cicatrização de colite ulcerativa induzida por ácido acético em ratos. Cinquenta e cinco ratos machos divididos em cinco grupos de tratamento iguais foram utilizados para este estudo e receberam os seguintes tratamentos: Grupo 1: 250 mg/kg de asacol; Grupo 2: 1 mL de gel base (carboximetilcelulose); Grupo 3: extrato de C. sempervirens a 0,5% em gel; Grupo 4: extrato de C. sempervirens a 1% em gel e; Grupo 5: considerado controle negativo que recebeu 1 mL de solução salina normal. Alterações no peso corporal, alterações histopatológicas e antioxidantes no tecido do cólon foram avaliadas. Ganho de peso significativo foi observado em ratos que receberam extrato em gel de C. sempervirens a 1%. Atividade significativa de superóxido dismutase também foi detectada em grupos de extrato em gel de 0,5 e 1% em comparação com o extrato de C. sempervirens, Asacol e em grupos de extrato em gel a 1% em comparação com o grupo base de gel. Além disso, ambos os grupos de extrato em gel apresentaram capacidade antioxidante total significativamente menor em comparação ao grupo Asacol. Várias lesões histopatológicas, incluindo inflamação, ulceração, desarranjo da cripta e depleção de células caliciformes foram detectadas nos diferentes grupos; no entanto, a classificação média de alterações patológicas não apresentou diferença significativa entre os cinco grupos. Em resumo, nossos resultados mostraram que extratos hidroalcoólicos de folhas de C. sempervirens produzem efeitos cicatrizantes em colite ulcerativa induzida por ácido acético. Keywords: Cupressus sempervirens, Ulcerative colitis, Histopathology, Antioxidant, Healing, Palavras-chave: Cupressus sempervirens, Colite ulcerativa, Histopatologia, Antioxidante, Cicatrizaçã

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. Methods Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects models with SDI as the main covariate, and YLDs were computed from the resulting prevalence forecasts and average disability weights from GBD. Alternative future scenarios were constructed by replacing appropriate reference trajectories for risk factors with hypothetical trajectories of gradual elimination of risk factor exposure from current levels to 2050. The scenarios were constructed from various sets of risk factors: environmental risks (Safer Environment scenario), risks associated with communicable, maternal, neonatal, and nutritional diseases (CMNNs; Improved Childhood Nutrition and Vaccination scenario), risks associated with major non-communicable diseases (NCDs; Improved Behavioural and Metabolic Risks scenario), and the combined effects of these three scenarios. Using the Shared Socioeconomic Pathways climate scenarios SSP2-4.5 as reference and SSP1-1.9 as an optimistic alternative in the Safer Environment scenario, we accounted for climate change impact on health by using the most recent Intergovernmental Panel on Climate Change temperature forecasts and published trajectories of ambient air pollution for the same two scenarios. Life expectancy and healthy life expectancy were computed using standard methods. The forecasting framework includes computing the age-sex-specific future population for each location and separately for each scenario. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings In the reference scenario forecast, global and super-regional life expectancy increased from 2022 to 2050, but improvement was at a slower pace than in the three decades preceding the COVID-19 pandemic (beginning in 2020). Gains in future life expectancy were forecasted to be greatest in super-regions with comparatively low life expectancies (such as sub-Saharan Africa) compared with super-regions with higher life expectancies (such as the high-income super-region), leading to a trend towards convergence in life expectancy across locations between now and 2050. At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. We also forecasted that both DALY counts and age-standardised DALY rates will continue to shift from CMNNs to NCDs, with the most pronounced shifts occurring in sub-Saharan Africa (60·1% [95% UI 56·8–63·1] of DALYs were from CMNNs in 2022 compared with 35·8% [31·0–45·0] in 2050) and south Asia (31·7% [29·2–34·1] to 15·5% [13·7–17·5]). This shift is reflected in the leading global causes of DALYs, with the top four causes in 2050 being ischaemic heart disease, stroke, diabetes, and chronic obstructive pulmonary disease, compared with 2022, with ischaemic heart disease, neonatal disorders, stroke, and lower respiratory infections at the top. The global proportion of DALYs due to YLDs likewise increased from 33·8% (27·4–40·3) to 41·1% (33·9–48·1) from 2022 to 2050, demonstrating an important shift in overall disease burden towards morbidity and away from premature death. The largest shift of this kind was forecasted for sub-Saharan Africa, from 20·1% (15·6–25·3) of DALYs due to YLDs in 2022 to 35·6% (26·5–43·0) in 2050. In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5–6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2–26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [–0·6 to 3·6]). Interpretation Globally, life expectancy and age-standardised disease burden were forecasted to improve between 2022 and 2050, with the majority of the burden continuing to shift from CMNNs to NCDs. That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. By constructing alternative future scenarios wherein certain risk exposures are eliminated by 2050, we have shown that opportunities exist to substantially improve health outcomes in the future through concerted efforts to prevent exposure to well established risk factors and to expand access to key health interventions