Deviations from early--time quasilinear behaviour for the quantum kicked rotor near the classical limit

We present experimental measurements of the mean energy for the atom optics kicked rotor after just two kicks. The energy is found to deviate from the quasi--linear value for small kicking periods. The observed deviation is explained by recent theoretical results which include the effect of a non--uniform initial momentum distribution, previously applied only to systems using much colder atoms than ours

Health, faith and therapeutic landscapes: Places of worship as black, Asian and Minority Ethnic (BAME) public health settings in the United Kingdom

Within the United Kingdom, there is evidence that faith-based affiliations, ideas, actors and organisations play a role in public health (PH) that has been neither properly recognised nor integrated into mainstream health systems (November, 2014). Discourses on faith and improving health outcomes have been particularly focused on 'seldom heard' groups, including 'Black, Asian and Minority Ethnic' (BAME) communities (November, 2014; Jain, 2014; Burton et al., 2017; Muhammad, 2018). In this paper we first present findings from a qualitative scoping study carried out in Leeds and Bradford, cities in the UK, between 2014 and 2015, which examined Places of Worship (PWs) as BAME PH settings. We carried out nineteen semi-structured interviews with purposively selected respondents, and three focus groups. Second, we develop a theory that originates from one in the sub-discipline of 'health geography' concerned with 'therapeutic landscapes', applying it to our research findings on PWs as BAME PH settings. The paper argues for the recentring of religion and faith settings back into the therapeutic landscapes literature, reflecting evidence that faith-based affiliations, ideas, actors and organisations are relevant to the pursuit of health and wellbeing. We also contend that a therapeutic landscapes framework provides a way of making the health relevance of PWs visible to both health practitioners and to members of PWs. We argue that PWs act as therapeutic places (i.e. specific transformative sacred sites) as well as therapeutic spaces (i.e. settings that provide adjuncts to formal PH promotion services), and are often part of therapeutic networks included in 'kinship groups and networks of care provided by family, friends, therapists and other agents of support' (Smyth, 2005: 490). This approach allows us to see how influences on health behaviour are not just confined to bio-medical settings, but that the 'healing process works itself out in places (or situations, locales, settings and milieus)' (Gesler, 1992: 743)

Fast object detection in pastoral landscapes using a multiple expert colour feature extreme learning machine

Fast and accurate object detection is a desire of many vision-guided robotics based systems. Agriculture is an area where detection accuracy is often sacrificed for speed, especially in the pursuit of real time results. Pastoral landscapes are especially challenging with varying levels of complexity, as competing objects are rarely textually smooth or visibly different from surroundings. This study presents a machine learning algorithm designed for object detection called the Multiple Expert Colour Extreme Learning Machine (MEC-ELM). The MEC-ELM is a multiple expert implementation of a Colour Feature Extreme Learning Machine (CF-ELM). The CF-ELM is itself a modification of the Extreme Learning Machine (ELM) with a partially connected hidden layer and a fully connected output layer, taking 3 inputs. The inputs can be utilised by multiple colour systems, including, RGB, Y'UV and HSV. Colour inputs were chosen, as colour is not sensitive to adjustments in scale, size and location and provides information not available in the standard grey-scale ELM. In the MEC-ELM algorithm, feature extraction and classification techniques were implemented simultaneously making a fully functional object detection algorithm. The algorithm was tested on weed detection and cattle detection from a video feed, delivering 0.89 (cattle) to 0.98 (weeds) accuracy in tuning and a precision of 0.61 to 0.95 in testing, with classification times between 0.5s to 1s per frame. The algorithm has been designed with complex and unpredictable terrain in mind, making it an ideal application for agricultural or pastoral landscapes

Experimental investigation of early-time diffusion in the quantum kicked rotor using a Bose-Einstein condensate

We report the experimental observation of resonances in the early-time momentum diffusion rates for the atom-optical delta-kicked rotor. In this work a Bose-Einstein condensate provides a source of ultra-cold atoms with an ultra-narow initial momentum distribution, which is then subjected to periodic pulses (or "kicks") using an intense far-detuned optical standing wave. A quantum resonance occurs when the momentum eigenstates accumulate the same phase between kicks leading to ballistic energy growth. Conversely, an anti-resonance is observed when the phase accumulated from successive kicks cancels and the system returns to its initial state. Our experimental results are compared with theoretical predictions.Comment: 6 pages, 6 figure

Radionuclide Decorporation: Matching the Biokinetics of Actinides by Transdermal Delivery of Pro-chelators

The threat of nuclear terrorism by the deliberate detonation of a nuclear weapon or radiological dispersion device ("dirty bomb") has made emergency response planning a priority. The only FDA-approved treatments for contamination with isotopes of the transuranic elements Am, Pu, and Cm are the Ca and Zn salts of diethylenetriaminepentaacetic acid (DTPA). These injectable products are not well suited for use in a mass contamination scenario as they require skilled professionals for their administration and are rapidly cleared from the circulation. To overcome the mismatch in the pharmacokinetics of the DTPA and the biokinetics of these transuranic elements, which are slowly released from contamination sites, the penta-ethyl ester of DTPA (C2E5) was prepared and formulated in a nonaqueous gel for transdermal administration. When gels comprised of 40% C2E5, 40-45% Miglyol® 840, and 15-20% ethyl cellulose were spiked with [(14)C]-C2E5 and applied to rat skin; over 60% of the applied dose was absorbed within a 24-h period. Radioactivity was observed in urinary and fecal excretions for over 3 days after removal of the gel. Using an (241)Am wound contamination model, transdermal C2E5 gels were able to enhance total body elimination and reduce the liver and skeletal burden of (241)Am in a dose-dependent manner. The efficacy achieved by a single 1,000 mg/kg dose to contaminated rats was statistically comparable to intravenous Ca-DTPA at 14 mg/kg. The effectiveness of this treatment, favorable sustained release profile of pro-chelators, and ease of administration support its use following radiological emergencies and for its inclusion in the Strategic National Stockpile

Species-dependent effective concentration of DTPA in plasma for chelation of 241AmI

Diethylenetriaminepentaacetic acid (DTPA) is a chelating agent that is used to facilitate the elimination of radionuclides, such as americium, from contaminated individuals. Its primary site of action is in the blood, where it competes with various biological ligands, including transferrin and albumin, for the binding of radioactive metals. To evaluate the chelation potential of DTPA under these conditions, the competitive binding of 241Am between DTPA and plasma proteins was studied in rat, beagle and human plasma in vitro. Following incubation of DTPA and 241Am in plasma, the 241Am-bound ligands were fractionated by ultrafiltration and ion-exchange chromatography, and each fraction was assayed for 241Am content by gamma scintillation counting. Dose-response curves of DTPA for 241Am binding were established, and these models were used to calculate the 90% maximal effective concentration, or EC90, of DTPA in each plasma system. The EC90 were determined to be 31.4, 15.9 and 10.0 μM in rat, beagle and human plasma, respectively. These values correspond to plasma concentrations of DTPA that maximize 241Am chelation while minimizing excess DTPA. Based on the pharmacokinetic profile of DTPA in humans, after a standard 30 μmol kg−1 intravenous bolus injection, the plasma concentration of DTPA remains above EC90 for approximately 5.6 h. Likewise, the effective duration of DTPA in rat and beagle were determined to be 0.67 and 1.7 h, respectively. These results suggest that species differences must be considered when translating DTPA efficacy data from animals to humans and offer further insights into improving the current DTPA treatment regimen

The Segmented Colour Feature Extreme Learning Machine: Applications in Agricultural Robotics

This study presents the Segmented Colour Feature Extreme Learning Machine (SCF-ELM). The SCF-ELM is inspired by the Extreme Learning Machine (ELM) which is known for its rapid training and inference times. The ELM is therefore an ideal candidate for an ensemble learning algorithm. The Colour Feature Extreme Learning Machine (CF-ELM) is used in this study due to its additional ability to extract colour image features. The SCF-ELM is an ensemble learner that utilizes feature mapping via k-means clustering, a decision matrix and majority voting. It has been evaluated on a range of challenging agricultural object classification scenarios including weed, livestock and machinery detection. SCF-ELM model performance results were excellent both in terms of detection, 90 to 99% accuracy, and also inference times, around 0.01(s) per image. The SCF-ELM was able to compete or improve upon established algorithms in its class, indicating its potential for remote computing applications in agriculture

Emergence of methicillin resistance predates the clinical use of antibiotics

The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development

Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of 'Artocarpus heterophyllus' Lam

Colorectal cancer (CRC) represents the third leading cause of death among cancer patients below the age of 50, necessitating improved treatment and prevention initiatives. A crude methanol extract from the wood pulp of Artocarpus heterophyllus was found to be the most bioactive among multiple others, and an enriched extract containing 84% (w/v) artocarpin (determined by HPLC–MS–DAD) was prepared. The enriched extract irreversibly inhibited the activity of human cytochrome P450 CYP2C9, an enzyme previously shown to be overexpressed in CRC models. In vitro evaluations on heterologously expressed microsomes, revealed irreversible inhibitory kinetics with an IC50 value of 0.46 μg/mL. Time- and concentration-dependent cytotoxicity was observed on human cancerous HCT116 cells with an IC50 value of 4.23 mg/L in 72 h. We then employed the azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-induced model in C57BL/6 mice, which revealed that the enriched extract suppressed tumor multiplicity, reduced the protein expression of proliferating cell nuclear antigen, and attenuated the gene expression of proinflammatory cytokines (Il-6 and Ifn-γ) and protumorigenic markers (Pcna, Axin2, Vegf, and Myc). The extract significantly (p = 0.03) attenuated (threefold) the gene expression of murine Cyp2c37, an enzyme homologous to the human CYP2C9 enzyme. These promising chemopreventive, cytotoxic, anticancer and anti-inflammatory responses, combined with an absence of toxicity, validate further evaluation of A. heterophyllus extract as a therapeutic agent