FM-track: a fiducial marker tracking software for studying cell mechanics in a three-dimensional environment

Tracking the deformation of fiducial markers in the vicinity of living cells embedded in compliant synthetic or biological gels is a powerful means to study cell mechanics and mechanobiology in three-dimensional environments. However, current approaches to track and quantify three-dimensional (3D) fiducial marker displacements remain ad-hoc, can be difficult to implement, and may not produce reliable results. Herein, we present a compact software package entitled “FM-Track,” written in the popular Python language, to facilitate feature-based particle tracking tailored for 3D cell micromechanical environment studies. FM-Track contains functions for pre-processing images, running fiducial marker tracking, and post-processing and visualization. FM-Track can thus aid the study of cellular mechanics and mechanobiology by providing an extensible software platform to more reliably extract complex local 3D cell contractile information in transparent compliant gel systems.https://www.sciencedirect.com/science/article/pii/S2352711019303474Published versio

Failed Secular Revolutions: Religious Belief, Competition, and Extremism

All advanced economies have undergone secular revolutions in which religious belief and institutions have been subordinated to secular forms of authority. There are, however, numerous examples of failed secular transitions. To understand these failures, we present a religious club model with endogenous entry and cultural transmission of religious beliefs. A spike in the demand for religious belief, due for example to a negative economic shock, induces a new and more extreme organization to enter the religious market and exploit the dissatisfaction of highly religious types with the religious incumbent. The eect is larger where institutional secularization is more advanced, for example where the religious establishment has moderated itself or has been moderated by the political authority. The greater the moderation of the religious incumbent, the more extreme is the position chosen by the religious entrant, and the larger is the rise in religious participation. Hence, unanticipated shifts in religious demand can lead to the emergence of new and more extreme religious organizations, and reverse previous trends toward secularization. Our model sheds light on the causes and consequences of failed secular revolutions and religious revivals in Latin America and Egypt

Exploring Relative Value Bias: Learned Outcomes or Choice Repetition?

People sometimes choose options yielding relatively better outcomes in past contexts, even when those options have lower absolute values. This study tested whether this effect is due to participants learning relative outcomes or simply repeating previous choices. Participants (n = 151) were randomly assigned to two conditions and completed a two-phase choice task. In the learning phase, participants either actively chose from (choice condition) or passively viewed (sampling condition) pairs of symbols and received reward feedback. In the subsequent transfer phase, participants were shown different combinations of the same symbols and were asked to choose the symbol with the higher value on each trial. Choice patterns in both conditions exhibited a bias towards lower-valued options yielding relatively greater outcomes in the learning phase. However, the effect was slightly stronger in the choice condition. Our findings suggest choice repetition plays a minor role, but cannot fully account for relative value choice biases.https://orb.binghamton.edu/research_days_posters_2024/1129/thumbnail.jp

Food policies for physical and mental health

Noncommunicable diseases (NCDs) account for the largest burden of early mortality and are predicted to cost the global community more than US $30 trillion over the next 20 years. Unhealthy dietary habits, in large part driven by substantial changes to global food systems, are recognised as major contributors to many of the common NCDs, including cardiovascular disease, cancer and diabetes. Recent evidence now indicates that unhealthy diets are also risk factors for mental disorders, particularly depression and dementia. This affords substantial scope to leverage on the established and developing approaches to the nutrition-related NCDs to address the large global burden of these mental disorders and reinforces the imperative for governments take substantial actions in regards to improving the food environment and consequent population health via policy initiatives

Counseling Athletes Who Use Performance-Enhancing Drugs: A New Conceptual Framework Linked to Clinical Practice

Doping, the use of performance-enhancing drugs by athletes, is a major concern that the media have publicized prominently. Sport governing bodies currently use two primary methods to dissuade athletes from doping: punishment and didactic education. Neither of these approaches has eradicated doping from competitive athletics because the practice appears to be increasing. Including clinical interventions in systemic campaigns that address this problem would be efficacious. The current article provides a conceptual framework that addresses doping from a psychologist’s perspective and then operationalizes this framework, all the while identifying the unique environment in which athletes function. Practical interventions for working with clients who dope are identified, as are possible future research paths that could benefit work with this population

Review of the Refeeding Syndrome

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142310/1/ncp0625.pd