1,336 research outputs found
The Lamb-Bateman integral equation and the fractional derivatives
The Lamb-Bateman integral equation was introduced to study the solitary wave
diffraction and its solution was written in terms of an integral transform. We
prove that it is essentially the Abel integral equation and its solution can be
obtained using the formalism of fractional calculus.Comment: 3 pages; revised version (misprints corrected, acknowledgements
added
Hysteresis effects in Bose-Einstein condensates
Here, we consider damped two-components Bose-Einstein condensates with
many-body interactions. We show that, when the external trapping potential has
a double-well shape and when the nonlinear coupling factors are modulated in
time, hysteresis effects may appear under some circumstances. Such hysteresis
phenomena are a result of the joint contribution between the appearance of
saddle node bifurcations and damping effect.Comment: 10 pages, 2 figure
Progress towards Bell-type polarization experiment with thermal neutrons
Experimental tests of Bell-type inequalities distinguishing between quantum
mechanics and local realistic theories remain of considerable interest if
performed on massive particles, for which no conclusive result has yet been
obtained. Only two-particle experiments may specifically test the concept of
spatial nonlocality in quantum theory, whereas single-particle experiments may
generally test the concept of quantum noncontextuality. Here we have performed
the first Bell-type experiment with a beam of thermal-neutron pairs in the
singlet state of spin, as originally suggested by J. S. Bell. These
measurements confirm the quantum-theoretical predictions, in agreement with the
results of the well-known polarization experiments carried out on optical
photons years ago
Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment. Current treatments for DED aim at lubricating and controlling inflammation of the ocular surface. Development of novel therapies targeting different pathogenic mechanisms is sought-after. The aim of this study is to evaluate safety and efficacy of recombinant human nerve growth factor (rhNGF) eye drops in patients with DED. Methods: Forty consecutive patients with moderate to severe DED were included in a phase IIa, prospective, open label, multiple-dose, clinical trial to receive rhNGF eye drops at 20 μg/mL (Group 1: G1) or at 4 μg/mL (Group 2: G2) concentrations, two times a day in both eyes for 28 days (NCT02101281). The primary outcomes measures were treatment-emerged adverse events (AE), Symptoms Assessment in Dry Eye (SANDE) scale, ocular surface staining and Schirmer test. Results: Of 40 included patients, 39 completed the trial. Both tested rhNGF eye drop concentrations were safe and well tolerated. Twenty-nine patients experienced at least one AE (14 in G1 and 15 in G2), of which 11 had at least 1 related AE (8 in G1 and 3 in G2). Both frequency and severity of DED symptoms and ocular surface damage showed significant improvement in both groups, while tear function improved only in G1. Conclusions: The data of this study indicate that rhNGF eye drops in both doses is safe and effective in improving symptoms and signs of DED. Randomised clinical trials are ongoing to confirm the therapeutic benefit of rhNGF in DED. Trial registration number: NCT02101281
Factors Influencing the Clinician\u27s Intention to Use AI Systems in Healthcare: A Value-Based Approach
Healthcare systems worldwide are in rapid transition, moving from traditional, paper-based practices to computerized approaches to improve service delivery. Consequently, interest in AI applications within medicine has been growing exponentially. The benefits of adopting such technology in a data-driven healthcare environment have been readily studied. However, few studies have investigated whether these AI-based medical interventions would be valued and used by clinicians. Thus, this study aims to extend a value-based adoption model (VAM) within the North American healthcare context to assess the clinician\u27s positive and negative views of AI and whether their perceptions of risks and benefits influence their intention to adopt the technology within their practice
Tuning topological disorder in MgB
We carried out Raman measurements on neutron-irradiated and Al-doped MgB
samples. The irradiation-induced topological disorder causes an unexpected
appearance of high frequency spectral structures, similar to those observed in
lightly Al-doped samples. Our results show that disorder-induced violations of
the selection rules are responsible for the modification of the Raman spectrum
in both irradiated and Al-doped samples. Theoretical calculations of the phonon
density of states support this hypothesis, and demonstrate that the high
frequency structures arise mostly from contributions at of the
E phonon mode.Comment: 4 pages, 4 figure
Pressure-tuning of the electron-phonon coupling: the insulator to metal transition in manganites
A comprehensive understanding of the physical origin of the unique magnetic
and transport properties of A_(1-x)A'^xMnO_3 manganites (A = trivalent
rare-earth and A' = divalent alkali-earth metal) is still far from being
achieved. The complexity of these systems arises from the interplay among
several competing interactions of comparable strength. Recently the
electron-phonon coupling, triggered by a Jahn-Teller distortion of the MnO_6
octahedra, has been recognised to play an essential role in the insulator to
metal transition and in the closely related colossal magneto-resistance. The
pressure tuning of the octahedral distortion gives a unique possibility to
separate the basic interactions and, at least in principle, to follow the
progressive transformation of a manganite from an intermediate towards a weak
electron-phonon coupling regime. Using a diamond anvil cell, temperature and
pressure-dependent infrared absorption spectra of La_(0.75)Ca_(0.25)MnO_3 have
been collected and, from the spectral weight analysis, the pressure dependence
of the insulator to metal transition temperature T_IM has been determined for
the first time up to 11.2 GPa. The T_IM(P) curve we proposed to model the
present data revealed a universality character in accounting for the whole
class of intermediate coupling compounds. This property can be exploited to
distinguish the intermediate from the weak coupling compounds pointing out the
fundamental differences between the two coupling regimes.Comment: 8 pages, 4 figure
Further evidence of antibunching of two coherent beams of fermions
We describe an experiment confirming the evidence of the antibunching effect
on a beam of non interacting thermal neutrons. The comparison between the
results recorded with a high energy-resolution source of neutrons and those
recorded with a broad energy-resolution source enables us to clarify the role
played by the beam coherence in the occurrence of the antibunching effect.Comment: 4 pages, 3 figure
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