Evaluation of cognitive impairment in rheumatoid arthritis: predictive value of joint destruction and disease activity

AMAÇ: Romatoid Artrit (RA), oryantasyon, dikkat ve bellek zayıflığı gibi azalmış bilişsel işlevlere neden olur. Sunulan bu çalışmanın amacı RA’da bilişsel işlevlerin bir belirleyicisi olarak eklem yıkımını ve hastalığın diğer parametrelerini değerlendirmektir. GEREÇ VE YÖNTEM: Bu kesitsel çalışma, 45 hasta ve 40 sağlıklı kontrol içemektedir. RA’lı hastalarda radyolojik progresyon skoru (≥0.5, modifiye Sharp / van der Heijde skorları- MTS’ler), 28 eklemin hastalık aktivite skoru (DAS-28) ve 44 eklemin hastalık aktivite skoru (DAS-44) değerlendirildi. Mini Mental Test (MMSE) ve Hastane Anksiyete Depresyon Ölçeği (HADÖ) değerlendirildi. Sonuçlar, bilişsel işlevleri belirlemek için hasta ve kontrol grubu arasında karşılaştırıldı. BULGULAR: MMSE skorları açısından gruplar arasında istatistiksel olarak anlamlı fark vardı (p=0.003). RA ve kontrol grupları arasında anksiyete ve depresyon düzeyleri açısından anlamlı farklılık yoktu. MMSE skoru; hastalık süresi (p=0.011, r=-0.371), Sharp skoru (p=0.018, r=-0.350) ve DAS-28(p=0.044, r=-0.296) skoru ile ilişkilendirildi. Depresyon skoru da DAS ile ilişkiliydi (p=0.004, r=0.425). Romatoid faktör düzeyleri, antisiklik sitrullinat peptid düzeyleri ve bilişsel işlev testleri arasında herhangi bir ilişki bulunamadı. SONUÇ: Sonuçlar, uzun süredir RA olan hastalarda inflamatuar mediatörlere maruz kalmanın, eklemleri etkilediği sürece merkezi sinir sisteminde de bozulmaya neden olabileceğini göstermektedir. Bilişsel bozulma, hastalık şiddeti ve eklem yıkımı ile ilişkili idi. Dolayısıyla, radyografik eklem hasarı, RA’daki bu kronik süreç boyunca nöronal hasarın ve bilişsel bozulmanın boyutunu yansıtan pozitif bir ön belirteç olabilir.OBJECTIVE: Rheumatoid Arthritis (RA) cause poor cognitive functions including reduced memory, orientation and attention. The aim of the present study is to evaluate joint destruction and other parameters of disease as a predictor of cognitive functions in RA. MATERIAL AND METHODS: This cross-sectional study included forty five patients and forty healthy controls. Radiological progression score (≥0.5 the modified Sharp/ van der Heijde scores- MTSs), disease activity score of 28 joints (DAS-28) and disease activity score of 44 joints (DAS-44) were evaluated in patients with RA. Mini Mental State Examination (MMSE) and Hospital Anxiety Depression Scale (HADS) were evaluated and the results were compared between patients and control groups to determinate cognitive functions. RESULTS: There was a statistically significant difference between groups in terms of MMSE scores (p=0.003). There were no significant differences in terms of anxiety and depression levels between RA and control groups. MMSE score was correlated with disease duration (p=0.011, r=- 0.371), Sharp score (p=0.018, r=-0.350) and DAS-28 score (p=0.044, r=-0.296). Depression score was also correlated with DAS (p=0.004, r=0.425). No relationship was found between Rheumatoid factor levels, anti-cyclic citrullinated peptide levels and the cognitive function tests. CONCLUSIONS: The results indicate that exposure to inflammatory mediators in patients with long standing RA may lead to deterioration on central nervous system as long as affecting joints. Cognitive deterioration was correlated with disease severity and joint destruction. Thus, the radiographic joint destruction can be a positive predictor of reflecting the extent of neuronal damage and cognitive deterioration during this chronic process in RA

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Conclusion: We found no correlation between PTX3 and disease activity score 28 or NLR, although PTX3 levels were higher in RA patients than the controls. As a result, we were unable to establish a relationship between PTX3 and disease activity, directly or indirectly. To our knowledge, our study was the first to investigate the relationship between PTX3 and NLR

Assessing the validity and reliability of the Turkish version of the Trunk Impairment Scale in stroke patients

CONCLUSION: TIS is a scale used in measuring the motor derangement that develops after a stroke. It has sufficient reliability, internal consistency, and validity for use in clinical practice and stroke investigations. Our study has shown that TIS used for the evaluation of body balance is valid and reliable for the Turkish population

The Evaluation of Serum Tumor Necrosis Factor-Like Weak Inducer of Apoptosis, Interleukin-6, Fetuin-A, Homeostatic Model Assessment-Insulin Resistance, and Insulin Levels in Rheumatoid Arthritis Patients in Clinical Remission

Conclusion: We found that RA patients had lower sTWEAK levels and higher fetuin-A levels than the control group subjects. Furthermore, these two molecules were associated with each other. This study demonstrated that in RA patients, even if the disease is controlled with treatment, some molecules associated with an increased metabolic and cardiovascular risk continue to function. Follow-up studies on larger populations are warranted to confirm these findings

Evaluation of cognitive impairment in rheumatoid arthritis: predictive value of joint destruction and disease activity

AMAÇ: Romatoid Artrit (RA), oryantasyon, dikkat ve bellek zayıflığı gibi azalmış bilişsel işlevlere neden olur. Sunulan bu çalışmanın amacı RA’da bilişsel işlevlerin bir belirleyicisi olarak eklem yıkımını ve hastalığın diğer parametrelerini değerlendirmektir. GEREÇ VE YÖNTEM: Bu kesitsel çalışma, 45 hasta ve 40 sağlıklı kontrol içemektedir. RA’lı hastalarda radyolojik progresyon skoru (≥0.5, modifiye Sharp / van der Heijde skorları- MTS’ler), 28 eklemin hastalık aktivite skoru (DAS-28) ve 44 eklemin hastalık aktivite skoru (DAS-44) değerlendirildi. Mini Mental Test (MMSE) ve Hastane Anksiyete Depresyon Ölçeği (HADÖ) değerlendirildi. Sonuçlar, bilişsel işlevleri belirlemek için hasta ve kontrol grubu arasında karşılaştırıldı. BULGULAR: MMSE skorları açısından gruplar arasında istatistiksel olarak anlamlı fark vardı (p=0.003). RA ve kontrol grupları arasında anksiyete ve depresyon düzeyleri açısından anlamlı farklılık yoktu. MMSE skoru; hastalık süresi (p=0.011, r=-0.371), Sharp skoru (p=0.018, r=-0.350) ve DAS-28(p=0.044, r=-0.296) skoru ile ilişkilendirildi. Depresyon skoru da DAS ile ilişkiliydi (p=0.004, r=0.425). Romatoid faktör düzeyleri, antisiklik sitrullinat peptid düzeyleri ve bilişsel işlev testleri arasında herhangi bir ilişki bulunamadı. SONUÇ: Sonuçlar, uzun süredir RA olan hastalarda inflamatuar mediatörlere maruz kalmanın, eklemleri etkilediği sürece merkezi sinir sisteminde de bozulmaya neden olabileceğini göstermektedir. Bilişsel bozulma, hastalık şiddeti ve eklem yıkımı ile ilişkili idi. Dolayısıyla, radyografik eklem hasarı, RA’daki bu kronik süreç boyunca nöronal hasarın ve bilişsel bozulmanın boyutunu yansıtan pozitif bir ön belirteç olabilir.OBJECTIVE: Rheumatoid Arthritis (RA) cause poor cognitive functions including reduced memory, orientation and attention. The aim of the present study is to evaluate joint destruction and other parameters of disease as a predictor of cognitive functions in RA. MATERIAL AND METHODS: This cross-sectional study included forty five patients and forty healthy controls. Radiological progression score (≥0.5 the modified Sharp/ van der Heijde scores- MTSs), disease activity score of 28 joints (DAS-28) and disease activity score of 44 joints (DAS-44) were evaluated in patients with RA. Mini Mental State Examination (MMSE) and Hospital Anxiety Depression Scale (HADS) were evaluated and the results were compared between patients and control groups to determinate cognitive functions. RESULTS: There was a statistically significant difference between groups in terms of MMSE scores (p=0.003). There were no significant differences in terms of anxiety and depression levels between RA and control groups. MMSE score was correlated with disease duration (p=0.011, r=- 0.371), Sharp score (p=0.018, r=-0.350) and DAS-28 score (p=0.044, r=-0.296). Depression score was also correlated with DAS (p=0.004, r=0.425). No relationship was found between Rheumatoid factor levels, anti-cyclic citrullinated peptide levels and the cognitive function tests. CONCLUSIONS: The results indicate that exposure to inflammatory mediators in patients with long standing RA may lead to deterioration on central nervous system as long as affecting joints. Cognitive deterioration was correlated with disease severity and joint destruction. Thus, the radiographic joint destruction can be a positive predictor of reflecting the extent of neuronal damage and cognitive deterioration during this chronic process in RA

Diagnostic Value of Musculoskeletal Ultrasound in Newly Diagnosed Rheumatoid Arthritis Patients

Conclusion: We demonstrated that the efficacy of US is comparable with that of contrast-enhanced MRI in detecting arthritis. However, clinicians must be careful so as to not obtain misleading information regarding MCP and PIP joints using US in patients with synovitis and erosions

Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis

CONCLUSION: In this study, we determined that AS had a significant influence on the working conditions and the factors related to the disease had a significant correlation with work productivity. Factors related to the psychology and the disease were also correlated with the working conditions

Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort

In this study, it was shown that the MASEI scores assessed by US were significantly higher in patients with PSS than in healthy controls. Plantar fascia, Achilles tendon, and distal patellar tendon were significantly thicker in the PSS group than in the healthy controls. This result suggests that PSS may be one of the causes of musculoskeletal pain that can be seen in patients with PSS. Our study was the first study to use an enthesis index ultrasonographically in patients with PSS. In addition, it is the first study to investigate the relationship between the presence of enthesopathy and disease activity by means of US

The relationship of pentraxin-3 levels with IL-17, fetuin-A, insulin in patients with Behcet's disease

Conclusions: Similar to CRP, PTX-3 is an acute-phase reactant that is considered an inflammatory and atherosclerotic biomarker. This study showed that PTX-3 levels can increase, similar to IL-17, but no relationship was detected between disease activity and coronary risk factors such as serum lipids, glucose intolerance and obesity. This was a cross-sectional study; therefore, the patients should be followed in long-term studies to determine whether higher PTX levels in BD patients are associated with a higher incidence of cardiovascular disease. Copyright (C) 2017, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC