Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A

A series of monomethoxy poly(ethylene glycol)–poly(lactide) (mPEG–PLA) diblock copolymers were designed according to polymer–drug compatibility and synthesized, and mPEG–PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun Neoral®), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug

Assessment: Feedback from Our Pasts, Feedforward for Our Futures

This chapter begins by pointing out that the behaviourist paradigm that still largely dominates assessment practices conflicts with more progressive understandings of constructivist and sociocultural approaches to learning and teaching. In order to progress assessment in Technology Education, Kay argues for adopting a pedagogic approach to assessment (where both teaching and assessment practices aim to support learning), maintaining authenticity in activities through which assessment is being undertaken, recognising the importance of judgement in valid processes of assessment, and maintaining a focus on equity and the inclusive role of the learner. The chapter also considers the potential affordances of new technologies in assessment. The chapter concludes by pointing out that future developments should support teachers to align learning and assessment. This is to ensure that learners engage in technological practice that makes visible to them and their teachers and assessors the learning that has taken place and the capability that has been developed

ARM-DOE/ACT: ACT Release Version 1.5.3

<h2>What's Changed</h2> <ul> <li>FIX: Update versioneer.py for python 3.12 support. by @zssherman in https://github.com/ARM-DOE/ACT/pull/720</li> <li>FIX: Fix failing geoplot test suite by @mgrover1 in https://github.com/ARM-DOE/ACT/pull/726</li> <li>ENH: Bug fix for geoplot example by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/722</li> <li>ENH: Adding ability to provide a img_tile found in cartopy.io.img_tiles. by @zssherman in https://github.com/ARM-DOE/ACT/pull/728</li> <li>FIX: Remove verify warning, by setting verify to true. by @zssherman in https://github.com/ARM-DOE/ACT/pull/729</li> <li>Preparing for discovery module standardization by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/724</li> <li>CI: Update coveragerc. by @zssherman in https://github.com/ARM-DOE/ACT/pull/735</li> <li>ADD: Adding new example for working with ARM QC and Xarray Transforma… by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/734</li> <li>ENH: Adding airnow to codecov by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/736</li> <li>FIX: Use the new syntax for setup micromamba by @mgrover1 in https://github.com/ARM-DOE/ACT/pull/745</li> <li>Updated DQR tool to use new DQR web-service. by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/743</li> <li>Pint update to stop warning by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/747</li> <li>MNT: Setup.cfg update by @zssherman in https://github.com/ARM-DOE/ACT/pull/749</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ARM-DOE/ACT/compare/v1.5.2...v1.5.3</p&gt

ARM-DOE/ACT: ACT Release Version 2.0.1

<p>This is the full 2.0.0 release plus a 2.0.1 release with a distribution fix that was breaking the conda build.</p> <h2>What's Changed</h2> <ul> <li>ADD: Adding arm site and facility location coordinate elastic search. by @zssherman in https://github.com/ARM-DOE/ACT/pull/751</li> <li>converting data to numpy array before checking data with numpy function by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/752</li> <li>V2 guide by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/746</li> <li>CI: Python 3 12 by @zssherman in https://github.com/ARM-DOE/ACT/pull/754</li> <li>ENH: Fix to resolve #750 for older ARM qc convention in files by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/755</li> <li>FIX: Fix for arm_elastic_search, missing space causing search issues. by @zssherman in https://github.com/ARM-DOE/ACT/pull/758</li> <li>DOC: Update main index page for v2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/759</li> <li>Improvements for the secondary y axis functionality by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/723</li> <li>Discovery changes for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/737</li> <li>MNT: Remove stamen for v2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/756</li> <li>IO Changes for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/739</li> <li>Changing default behavior for data filter for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/740</li> <li>ENH: Removing HistogramDisplay and updating functions to remove graph… by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/741</li> <li>FIX: Fix for examples to be updated to new discovery.download_arm_data. by @zssherman in https://github.com/ARM-DOE/ACT/pull/760</li> <li>DOC: Update readme for version 2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/761</li> <li>ENH: Use arm-test-data repo for unit testing by @zssherman in https://github.com/ARM-DOE/ACT/pull/762</li> <li>ENH: Update examples to use arm_test_data repo and remove old test files. by @zssherman in https://github.com/ARM-DOE/ACT/pull/763</li> <li>DOC: Update docs on release candidate. by @zssherman in https://github.com/ARM-DOE/ACT/pull/764</li> <li>ENH: Grammatical error in V2 guide and pointing readme to documentati… by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/765</li> <li>ENH: Reverting back the secondary y-axis change and removing the seco… by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/769</li> <li>Correctly inserting two nan values for 2D plots to ensure minimal streaking in plot. by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/770</li> <li>TST: Reorganize the entire test module. by @zssherman in https://github.com/ARM-DOE/ACT/pull/771</li> <li>ENH: New options to the skewt plot to close out #699 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/775</li> <li>Base functionality to create movies from images by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/776</li> <li>ENH: Updating tests for plotting to increase coverage by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/777</li> <li>Adding functionality to generate_movie(). by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/778</li> <li>Catching divide by 0 error before it errors. by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/780</li> <li>Updating time_height_scatter and more of the tests in the timeseries test module by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/779</li> <li>FIX: Fix for missing tests in distribution. by @zssherman in https://github.com/ARM-DOE/ACT/pull/782</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ARM-DOE/ACT/compare/v1.5.3...v2.0.1</p&gt

ARM-DOE/ACT: ACT Pre-release Candidate v2.0.0-rc.0

<h2>What's Changed</h2> <ul> <li>ADD: Adding arm site and facility location coordinate elastic search. by @zssherman in https://github.com/ARM-DOE/ACT/pull/751</li> <li>converting data to numpy array before checking data with numpy function by @kenkehoe in https://github.com/ARM-DOE/ACT/pull/752</li> <li>V2 guide by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/746</li> <li>CI: Python 3 12 by @zssherman in https://github.com/ARM-DOE/ACT/pull/754</li> <li>ENH: Fix to resolve #750 for older ARM qc convention in files by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/755</li> <li>FIX: Fix for arm_elastic_search, missing space causing search issues. by @zssherman in https://github.com/ARM-DOE/ACT/pull/758</li> <li>DOC: Update main index page for v2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/759</li> <li>Improvements for the secondary y axis functionality by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/723</li> <li>Discovery changes for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/737</li> <li>MNT: Remove stamen for v2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/756</li> <li>IO Changes for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/739</li> <li>Changing default behavior for data filter for V2.0.0 by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/740</li> <li>ENH: Removing HistogramDisplay and updating functions to remove graph… by @AdamTheisen in https://github.com/ARM-DOE/ACT/pull/741</li> <li>FIX: Fix for examples to be updated to new discovery.download_arm_data. by @zssherman in https://github.com/ARM-DOE/ACT/pull/760</li> <li>DOC: Update readme for version 2.0. by @zssherman in https://github.com/ARM-DOE/ACT/pull/761</li> <li>ENH: Use arm-test-data repo for unit testing by @zssherman in https://github.com/ARM-DOE/ACT/pull/762</li> <li>ENH: Update examples to use arm_test_data repo and remove old test files. by @zssherman in https://github.com/ARM-DOE/ACT/pull/763</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ARM-DOE/ACT/compare/v1.5.3...v2.0.0-rc.0</p&gt