31 research outputs found
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
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- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
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- Creteur J
- Creteur J
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- Crimella F
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- Cuellar AI
- Cui N
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- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
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- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
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- Day A
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- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
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- de Wilde W
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- Deblier I
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- Del Rosario CG
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- Di Gravio V
- Di Gregorio A
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- Dimopoulou IK
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- Elbers PW
- Elgendy M
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- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Eroles AA
- Escalada SH
- Escalada SH
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- Escórcio S
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- Espinasse F
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- Fernández IF
- Fernández L
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- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
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- Ferri F
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- Ferrón FR
- Ferrón FR
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- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
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- Follin A
- Follin A
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- Fontaiña LP
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- Frithiof R
- Fritz C
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- Fromentin M
- Frontera PR
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- Gadgil S
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- Garcia-Alvarez JM
- Garcia-Alvarez JM
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- García-Martínez MV
- García-Olivares P
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- Gavrychenko D
- Gayat E
- Geantot MA
- Gemmell L
- Gemmell LK
- Genc D
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- Geri G
- GETGAG Working Group
- GETGAG/SEMICYUC
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- Ghazal S
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- Giesinger RE
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- Gommers D
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- Gonçalves B
- Goodwin S
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- Gordillo-Brenes A
- Gordo F
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- Gordon M
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- Gouveia J
- Gracia RM
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- Granados PR
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- Grangé S
- Granillo JF
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- Grossestreuer A
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- Guidet B
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- Hernández A
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- Hernández AA
- Hernández AA
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- Hernández-Tejedor A
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- Hualde JB
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- Hualde JB
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- Hualde JB
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- Huang WC
- Huang WC
- Huang WC
- Huang WC
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- Huber W
- Huddart S
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- Hung CY
- Hung WT
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- Husheer SL
- Hutchings S
- Hutchison R
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- Hwang GS
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- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- Iotti GA
- IPREA Study Group
- Irazabal JM
- Irazabal JM
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- Itenov TS
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- Jacobs FM
- Jacques T
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- Jang BH
- Janotka M
- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
- Jeong WY
- Jeong WY
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- Jiao LR
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- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
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- Jun IG
- Jung K
- Jung KW
- Junior JM
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- Kaminsky GE
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- Katabami K
- Katabami K
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- Kim JM
- Kim JW
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- Kolnikova I
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- Kouatchet A
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- Krishna B
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Labra C
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- Lafuente E
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- Lai CH
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- Latini R
- Latini R
- Latini R
- Latorre J
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- Lichtenstein D
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- Lin KC
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- Lin PH
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- Lin WC
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- Lischinsky A
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- Llorente MÁ
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- Lobo-Civico A
- Loizou C
- Lombardo MD
- Londoño JG
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- Lopez-Gude MJ
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- Lortat-Jacob B
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- Loudet CI
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- Louf-Durier A
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- Lozano JA
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- Lucinio NM
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- Lukaszewicz AC
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- López AR
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- López MA
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- MacKay A
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- Mackey G
- MacPhee I
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- Madueño VP
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- Maekawa K
- Maekawa K
- Maekawa K
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- Maghsoudi B
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- Magnoni S
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- Maistry N
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- Mancebo J
- Mancebo J
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- Mar GY
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- Marca L
- Marcos-Zambrano LJ
- Mariani M
- Mariman A
- Marin-Mateos H
- Marine-Vidal J
- Mariotte E
- Mariotti L
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- Marmanidou K
- Marqués-Miñana MR
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- Martí AT
- Martín MC
- Martín-Loeches I
- Martín-Loeches I
- Martínez F
- Martínez L
- Martínez L
- Martínez M
- Martínez MP
- Martínez MV
- Martínez NA
- Martínez-Carmona JF
- Marín-Corral J
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- Masjedi M
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- Masson S
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- Matamis D
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- Mathew R
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- McPhail MJ
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- Mecklenburg A
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- Mejías CR
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- Melnyk L
- Melo N
- Mendes A
- Mendez MC
- Mendonca AV
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- Menendez R
- Mengelle C
- Mercat A
- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
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- Mezidi M
- Michel L
- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
- Millar M
- Mimoun M
- Mimoz O
- Min A
- Min HJ
- Mingone D
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- Mirabella L
- Miranda F
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- Mistry M
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- Mohammed HM
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- Monroy NS
- Monsalvo S
- Montejo-González JC
- Montenegro AP
- Montenegro WS
- Montero JG
- Montero RM
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- Montgomery HE
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- Montoya AA
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- Montravers P
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- Moon YJ
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- Mora-Ordóñez JM
- Moraes RB
- Morais CC
- Morales RC
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- Morimoto T
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- Moro F
- Morán I
- Motos A
- Mouaci A
- Mourad M
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- Muhammad JB
- Mukherjee DN
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- Murakami H
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Olavarria E
- Olea-Jiménez V
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- Olkkola KT
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- Ono Y
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- Ori C
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- Orozco V
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Experience of parents who have suffered a perinatal death in two Spanish hospitals: a qualitative study
- Author
- A Ellis
- A Linde
- A Payás
- AE Heazell
- AEP Heazell
- AM Üstündağ-Budak
- C Burden
- C Chojenta
- C Dirix
- C Kingdon
- Cayetano Fernández-Sola
- CB Ogwulu
- Curt A. Sandman
- D Bakhbakhi
- D Côté-Arsenault
- D Horey
- DJ Krosch
- Euro-Peristat Project
- Francisca Rosa Jiménez-López
- GC Smith
- H Lindgren
- H Mistry
- HG Gadamer
- HM Osman
- I Ridaura
- I Rådestad
- IK Gravensteen
- IK Gravensteen
- Instituto Nacional de Estadística
- Isabel María Fernández-Medina
- J Cacciatore
- J Huberty
- J O’Leary
- J Warland
- J Warland
- J Warland
- JA Di-Pietro
- JE Lawn
- JL Rosenbaum
- JM Page
- JM Youngblut
- José Granero-Molina
- José Manuel Hernández-Padilla
- JW Worden
- K Erlandsson
- K Lisy
- K Ryninks
- KJ Doka
- KJ Doka
- L Brierley-Jones
- L Koopmans
- L Nappi
- Laura Martínez-Artero
- M Fernández-Alcántara
- MA Einaudi
- Marcos Camacho-Ávila
- MC Chung
- MC Malm
- N Asplin
- P Nikula
- PR Cassidy
- S Meaney
- S Murphy
- S Pullen
- S Steen
- SD Yilmaz
- SM Pastor-Montero
- Soo Downe
- T Stacey
- V Fleming
- V Flenady
- V Gopichandran
- YF Tseng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2019
- Field of study
Background: Perinatal grief is a process that affects families in biological, psychological, social and spiritual terms. It is estimated that every year there are 2.7 million perinatal deaths worldwide and 4.43 deaths for every 1000 births in Spain. The aim of this study is to describe and understand the experiences and perceptions of parents who have suffered a perinatal death. Methods: A qualitative study based on Gadamer’s hermeneutic phenomenology. The study was conducted in two hospitals in the South of Spain. Thirteen mothers and eight fathers who had suffered a perinatal death in the 5 years prior to the study participated in this study. In-depth interviews were carried out for data collection. Inductive analysis was used to find themes based on the data. Results: Eight sub-themes emerged, and they were grouped into three main themes: ‘Perceiving the threat and anticipating the baby’s death: “Something is going wrong in my pregnancy”’; ‘Emotional outpouring: the shock of losing a baby and the pain of giving birth to a stillborn baby’; “We have had a baby”: The need to give an identity to the baby and legitimise grief’. Conclusion: The grief suffered after a perinatal death begins with the anticipation of the death, which relates to the mother’s medical history, symptoms and premonitions. The confirmation of the death leads to emotional shock, characterised by pain and suffering. The chance to take part in mourning rituals and give the baby the identity of a deceased baby may help in the grieving and bereavement process. Having empathy for the parents and notifying them of the death straightaway can help ease the pain. Midwives can help in the grieving process by facilitating the farewell rituals, accompanying the family, helping in honouring the memory of the baby, and supporting parents in giving the deceased infant an identity that makes them a family member
A forma abreviada da escala posições frente ao diagnóstico de enfermagem: desenvolvimento e avaliação psicométrica
- Author
- Anna J. Frandsen
- Antonio Martínez-Sabater
- Colton T
- Cristina Castro-Yuste
- Cristina O'Ferrall-González
- Cruz DALM
- De Vet HC
- Dillman DA
- Dillman DA
- Eva María Gabaldón-Bravo
- Fishbein M
- Granello DH
- Hair J
- Halberstadt SM
- Husted JA
- Jensen R
- José Manuel Romero-Sánchez
- Juan Carlos Paramio-Cuevas
- Kline P
- Lunney M
- Lunney M
- María Eugenia González-Domínguez
- Nunnally JC
- Olga Paloma-Castro
- Oliva APV
- Polit DF
- Romero-Sánchez JM
- Sonia María Pastor-Montero
- Streiner DL
- Swets JA
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
The Positions on Nursing Diagnosis (PND) is a scale that uses the semantic differential technique to measure nurses' attitudes towards the nursing diagnosis concept. The aim of this study was to develop a shortened form of the Spanish version of this scale and evaluate its psychometric properties and efficiency. A double theoretical-empirical approach was used to obtain a short form of the PND, the PND-7-SV, which would be equivalent to the original. Using a cross-sectional survey design, the reliability (internal consistency and test-retest reliability), construct (exploratory factor analysis, known-groups technique and discriminant validity) and criterion-related validity (concurrent validity), sensitivity to change and efficiency of the PND-7-SV were assessed in a sample of 476 Spanish nursing students. The results endorsed the utility of the PND-7-SV to measure attitudes toward nursing diagnosis in an equivalent manner to the complete form of the scale and in a shorter time.El Position on Nursing Diagnosis (PND) es una escala que utiliza la técnica del diferencial semántico para medir las actitudes hacia el concepto diagnóstico enfermero. El estudio objetivó desarrollar una forma abreviada de la versión española de esta escala, evaluar sus propiedades psicométricas y eficiencia. Se utilizó un doble enfoque empírico-teórico para obtener una forma reducida del PND, el PND-7-SV, que fuera equivalente a la original. Mediante un diseño transversal a través de encuesta, se evaluó la fiabilidad (consistencia interna y fiabilidad test-retest), validez de constructo (análisis factorial exploratorio, técnica de grupos conocidos y validez discriminante) y de criterio (validez concurrente), sensibilidad al cambio y eficiencia del PND-7-SV en una muestra de 476 estudiantes de enfermería españoles. Los resultados avalaron la utilidad del PND-7-SV para medir las actitudes hacia el diagnóstico enfermero de manera equivalente a la forma completa de la escala y en un tiempo más reducido
Repercussões maternas do diagnóstico pré-natal de anomalia fetal
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The embryo as moral work object: PGD/IVF staff views and experiences
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
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- Vetterli MC
- Vetterli MC
- Vichou I
- Vichou I
- Vickey T
- Vickey T
- Viegas FJTA
- Viehhauser GHA
- Viehhauser GHA
- Viel S
- Villa M
- Villa M
- Villani EG
- Vilucchi E
- Vilucchi E
- Vincter MG
- Vincter MG
- Vinek E
- Vinek E
- Vinogradov VB
- Vinogradov VB
- Virchaux M
- Viret S
- Viret S
- Virzi J
- Virzi J
- Vitale A
- Vitale A
- Vitells O
- Vitells O
- Viti M
- Vivarelli I
- Vivarelli I
- Vlachos S
- Vlachos S
- Vlasak M
- Vlasak M
- Vlasov N
- Vlasov N
- Vogel A
- Vogel A
- Vokac P
- Vokac P
- Volpi G
- Volpi M
- Volpi M
- Volpini G
- von der Schmitt H
- von der Schmitt H
- von Loeben J
- von Loeben J
- von Radziewski H
- von Radziewski H
- von Toerne E
- von Toerne E
- Vorobel V
- Vorobel V
- Vorobiev AP
- Vorwerk V
- Vorwerk V
- Vos M
- Vos M
- Voss R
- Voss R
- Voss TT
- Voss TT
- Vossebeld JH
- Vossebeld JH
- Vovenko AS
- Vranjes N
- Vranjes N
- Vrba V
- Vrba V
- Vreeswijk M
- Vreeswijk M
- Vudragovic D
- Vuillermet R
- Vuillermet R
- Vukotic I
- Vukotic I
- Wagner P
- Wagner P
- Wagner W
- Wahlen H
- Wakabayashi J
- Walbersloh J
- Walbersloh J
- Walch S
- Walder J
- Walder J
- Walker R
- Walker R
- Walkowiak W
- Walkowiak W
- Wall R
- Wall R
- Waller P
- Wang C
- Wang C
- Wang H
- Wang H
- Wang H
- Wang J
- Wang J
- Wang J
- Wang JC
- Wang R
- Wang SM
- Wang SM
- Warburton A
- Warburton A
- Ward CP
- Ward CP
- Warsinsky M
- Warsinsky M
- Wastie R
- Watkins PM
- Watkins PM
- Watson AT
- Watson AT
- Watson MF
- Watson MF
- Watts G
- Watts G
- Watts S
- Watts S
- Waugh AT
- Waugh AT
- Waugh BM
- Waugh BM
- Weber J
- Weber M
- Weber M
- Weber MD
- Weber MS
- Weber MS
- Weber P
- Weber P
- Weidberg AR
- Weidberg AR
- Weigell P
- Weingarten J
- Weingarten J
- Weiser C
- Weiser C
- Wellenstein H
- Wellenstein H
- Wells PS
- Wells PS
- Wen M
- Wenaus T
- Wenaus T
- Wendler S
- Wendler S
- Weng Z
- Weng Z
- Wengler T
- Wengler T
- Wenig S
- Wenig S
- Wermes N
- Wermes N
- Werner M
- Werner M
- Werner P
- Werner P
- Werth M
- Werth M
- Werthenbach U
- Wesse
- Wessels M
- Whalen K
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik LAM
- Wildauer A
- Wildt MA
- Wilkens HG
- Williams E
- Williams HH
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winklmeier F
- Wittgen M
- Wolter MW
- Wolters H
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wraight K
- Wright C
- Wright D
- Wrona B
- Wu SL
- Wu X
- Wulf E
- Wynne BM
- Xaplanteris L
- Xella S
- Xie S
- Xu D
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Z
- Yao WM
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef SP
- Yu D
- Yu J
- Yuan L
- Yurkewicz A
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zambrano V
- Zanello L
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang H
- Zhang J
- Zhang Q
- Zhang X
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zutshi V D
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2008
- Field of study
Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and experiences of practitioners and scientists on social, ethical and clinical dilemmas encountered when working in the field of preimplantation genetic diagnosis (PGD) for serious genetic disorders. The study produced an ethnography based on observation, interviews and ethics discussion groups with staff from two PGD/IVF Units in the UK. We focus here on staff perceptions of work with embryos that entails disposing of ‘affected’ or ‘spare’ embryos or using them for research. A variety of views were expressed on the ‘embryo question’ in contrast to polarised media debates. We argue that the prevailing policy acceptance of destroying affected embryos, and allowing research on embryos up to 14 days leaves some staff with rarely reported, ambivalent feelings. Staff views are under-researched in this area and we focus on how they may reconcile their personal moral views with the ethical framework in their field. Staff construct embryos in a variety of ways as ‘moral work objects’. This allows them to shift attention between micro-level and overarching institutional work goals, building on Casper's concept of ‘work objects’ and focusing on negotiation of the social order in a morally contested field.The Wellcome Trust Biomedical Ethics Programme, who funded the projects‘Facilitating choice, framing choice: the experience of staff working in pre-implantation genetic diagnosis’ (no: 074935), and ‘Ethical Frameworks for Embryo Donation:the views and practices of IVF/PGD staff’ (no: 081414)
Cell death pathologies: targeting death pathways and the immune system for cancer therapy
- Author
- A Ashkenazi
- A Degterev
- A Degterev
- A Fouque
- A Hantusch
- A Kaczmarek
- A Kotschy
- A Linkermann
- A Lujambio
- A Marini
- A Muir
- A Ribas
- A Rufini
- A Rufini
- A Witt
- AD Garg
- AH Stegh
- AJ Souers
- AK Marwaha
- AM Crompton
- AM Dudek
- AO Guerreiro-Cacais
- AW Roberts
- AW Roberts
- BR Stockwell
- C Espadinha
- C Hernandez
- C Kandoth
- CA Brady
- D Hanahan
- D Vercammen
- D Vercammen
- DF Tschaharganeh
- DV Krysko
- E Candi
- E Candi
- E Perez
- E Vacchelli
- EM Alexandrova
- EM Carrington
- EM Memmi
- ER Kastenhuber
- F Kruiswijk
- FR Abdul Razak
- Francesca Pentimalli
- G Anovazzi
- G Lessene
- Gerry Melino
- GW Dorn 2nd
- GZ Ng
- H Inoue
- H Solomon
- H Zhao
- HC Tu
- HO Fearnhead
- I Amelio
- I Amelio
- I Amelio
- I Lopez
- Ivano Amelio
- J Durgan
- J Liang
- J Montero
- JA Roth
- JD Leverson
- JI Belle
- JM Lowe
- JM Murphy
- JM Wilson
- JW Upton
- KH Khoo
- KT Bieging
- L Dara
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Jiang
- LA Timmerman
- LM Smith
- LT Vassilev
- M Aggarwal
- M Charni
- M Charni
- M Hayano
- M Jamal-Hanjani
- M Krajcovic
- M Krajcovic
- M Napoli
- M Overholtzer
- M Pawar
- M Sundvall
- M Wang
- MA Postow
- N Senzer
- N Zanesi
- Nicola Di Daniele
- O Florey
- O Florey
- O Merkel
- P Bose
- P Casara
- P Nana-Sinkam
- P Pihan
- P Rivetti di Val Cervo
- P Vandenabeele
- P Vandenabeele
- P Vikhreva
- Q Sun
- Q Xia
- R Brigelius-Flohe
- R Reinhart
- R Valdes-Mas
- S Dolma
- S Fouchecourt
- S Kehrloesser
- S Krishna
- S Lehmann
- Sandro Grelli
- SE Kim
- SJ Dixon
- SJ Dixon
- SM Chan
- SS Mello
- SY Seong
- T Vanden Berghe
- TC Messemaker
- TN Nguyen
- V Molinier-Frenkel
- V Peperzak
- VJN Bykov
- WA Freed-Pastor
- WA Freed-Pastor
- WJ Kaiser
- WJ Kaiser
- WS Yang
- WS Yang
- X Liu
- Y Pekarsky
- Y Xie
- Z Salah
- ZS Guo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/12/2018
- Field of study
Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically been exclusively associated with classical apoptosis; however, increasing evidence indicates that several alternative mechanisms orchestrate multiple death pathways, such as ferroptosis, entosis, necroptosis and immunogenic cell death, each with distinct underlying molecular mechanisms. Although pharmacological targeting of cell death pathways has been the subject of intensive efforts in recent decades with a dominant focus on targeting apoptosis, the identification of these novel death pathways has opened additional venues for intervention in cancer cells and the immune system. In this mini-review, we cover some recent progress on major recently emerged cell death modalities, emphasizing their potential clinical and therapeutic implications. We also discuss the interplay between cell death and immune response, highlighting the potential of the combination of traditional anticancer therapy and immunocheckpoint blockade. While attempting to stimulate discussion and draw attention to the possible clinical impact of these more recently emerged cell death modalities, we also cover the major progress achieved in translating strategies for manipulation of apoptotic pathways into the clinic, focusing on the attempts to target the anti-apoptotic protein BCL2 and the tumour suppressor p53
Cell death pathologies: targeting death pathways and the immune system for cancer therapy
- Author
- A Ashkenazi
- A Degterev
- A Degterev
- A Fouque
- A Hantusch
- A Kaczmarek
- A Kotschy
- A Linkermann
- A Lujambio
- A Marini
- A Muir
- A Ribas
- A Rufini
- A Rufini
- A Witt
- AD Garg
- AH Stegh
- AJ Souers
- AK Marwaha
- AM Crompton
- AM Dudek
- AO Guerreiro-Cacais
- AW Roberts
- AW Roberts
- BR Stockwell
- C Espadinha
- C Hernandez
- C Kandoth
- CA Brady
- D Hanahan
- D Vercammen
- D Vercammen
- DF Tschaharganeh
- DV Krysko
- E Candi
- E Candi
- E Perez
- E Vacchelli
- EM Alexandrova
- EM Carrington
- EM Memmi
- ER Kastenhuber
- F Kruiswijk
- FR Abdul Razak
- Francesca Pentimalli
- G Anovazzi
- G Lessene
- Gerry Melino
- GW Dorn 2nd
- GZ Ng
- H Inoue
- H Solomon
- H Zhao
- HC Tu
- HO Fearnhead
- I Amelio
- I Amelio
- I Amelio
- I Lopez
- Ivano Amelio
- J Durgan
- J Liang
- J Montero
- JA Roth
- JD Leverson
- JI Belle
- JM Lowe
- JM Murphy
- JM Wilson
- JW Upton
- KH Khoo
- KT Bieging
- L Dara
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Jiang
- LA Timmerman
- LM Smith
- LT Vassilev
- M Aggarwal
- M Charni
- M Charni
- M Hayano
- M Jamal-Hanjani
- M Krajcovic
- M Krajcovic
- M Napoli
- M Overholtzer
- M Pawar
- M Sundvall
- M Wang
- MA Postow
- N Senzer
- N Zanesi
- Nicola Di Daniele
- O Florey
- O Florey
- O Merkel
- P Bose
- P Casara
- P Nana-Sinkam
- P Pihan
- P Rivetti di Val Cervo
- P Vandenabeele
- P Vandenabeele
- P Vikhreva
- Q Sun
- Q Xia
- R Brigelius-Flohe
- R Reinhart
- R Valdes-Mas
- S Dolma
- S Fouchecourt
- S Kehrloesser
- S Krishna
- S Lehmann
- Sandro Grelli
- SE Kim
- SJ Dixon
- SJ Dixon
- SM Chan
- SS Mello
- SY Seong
- T Vanden Berghe
- TC Messemaker
- TN Nguyen
- V Molinier-Frenkel
- V Peperzak
- VJN Bykov
- WA Freed-Pastor
- WA Freed-Pastor
- WJ Kaiser
- WJ Kaiser
- WS Yang
- WS Yang
- X Liu
- Y Pekarsky
- Y Xie
- Z Salah
- ZS Guo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry
- Author
- A Bateman
- A Grove
- A Mustaev
- A Mérens
- A Roy
- A Sugino
- A Wohlkonig
- AA Belogurov
- AD Bates
- AM Emmerson
- AM Muro-Pastor
- BD Bax
- BD Bax
- BE Ramirez
- C Levine
- C Montero
- CD Mol
- CD Putnam
- CD Putnam
- CJ Dorman
- CJ Kenyon
- DB Wigley
- DE Whitworth
- DS Horowitz
- DT Dryden
- E León
- EC Friedberg
- EL Fonseca
- EL Zechiedrich
- F Collin
- F Moreno
- G Jacoby
- G Serrano-Heras
- GA Jacoby
- H Yoshida
- H-C Wang
- HC Wang
- HC Wang
- HC Wang
- HC Wang
- HR Drew
- I Laponogov
- I Laponogov
- I Laponogov
- I Laponogov
- I Takahashi
- J Felsenstein
- J Heddle
- J Papillon
- J Strahilevitz
- J Tao
- J-P Kruse
- JG Heddle
- JG Heddle
- JH Tran
- JH Tran
- JJ Champoux
- JJ Lopez-Rubio
- JL Asensio
- JM Rodríguez-Martínez
- Jonathan G. Heddle
- JS Richardson
- K Black
- K Drlica
- K Mizuuchi
- K Tamura
- KC Murphy
- L Brino
- L Martínez-Martínez
- L Poirel
- L Tora
- LM Cavaco
- LM Parsons
- M Chatterji
- M Fontes
- M Ghosh
- M Hata
- M Nei
- M Nollmann
- M Wang
- MA Larkin
- MC Garrido
- MD Walkinshaw
- MJ Romanowski
- MM Babu
- MM Cox
- MM Tavío
- MW Vetting
- MW Vetting
- MW Vetting
- MW Vetting
- MW Vetting
- NA Baker
- NL Williams
- NL Williams
- NL Williams
- NP Higgins
- O Lomovskaya
- ON Voloshin
- Q Guo
- R Cone
- R Court
- R Kolter
- R Loris
- RA Stabler
- RG Birch
- RG Birch
- RM Exley
- S Arsène
- S Ni
- S Ni
- SA McMahon
- SC Kampranis
- SC Kampranis
- Shama Shah
- SM Hashimi
- SS Hegde
- SS Hegde
- SV Nekrasov
- T Ogura
- T Yasuda
- TW Kirby
- VE Galkin
- WM Parks
- X Xiong
- Y Nakamura
- Y Zhang
- Z Wang
- Z Wang
- ZG Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study
- Author
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aiman M
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba A
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Alvarez Montero L
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antonelli Massimo
- Antônio AP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabi YM
- Arabi Yaseen M.
- Araujo AM
- Arizmendi A
- Arnal JM
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Bauer Philippe R.
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani Giacomo
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Bermejo Lopez E
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Blasco Navalpotro MA
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard Laurent
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Bumbasirevic Vesna
- Burtenshaw AJ
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Canestrini S
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
- Casement J
- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato VI
- Cervantes MR
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
- Chena A
- Chiche JD
- Chouchene I
- Choudry S
- Christiansen A
- Cimic N
- Cinnella G
- Cirone R
- Citalán JE
- Claraco-Vega LM
- Clarkson K
- Clarkson KP
- Claverias L
- Cohen JE
- Cole JM
- Collins DV
- Collyer T
- Colombo R
- Combaux DM
- Combes A
- Cooper R
- Coppadoro A
- Corneci DE
- Cortegiani A
- Cortez CA
- Coxo CM
- Cracchiolo AN
- Cranshaw JH
- Crapelli G
- Crouch DR
- Crouch DR
- Crova PJ
- Csabi P
- Curley G
- Daldin J
- Dangers L
- Danin PE
- Daubin C
- Daviaud F
- Davies KG
- Dawson H
- De Cima-Iglesias S
- De Haro C
- De Pablo R
- de Prost N
- Dean MN
- Declercq PM
- Dector D
- Dector DM
- Deicas A
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman SS
- Di Tomasso NN
- Di YD
- Diaz Abad R
- Diaz-Rodriguez E
- Dive AM
- Dixit SB
- do Vale Fernandes A
- Dolva MS
- Donnelly A
- Dowling AT
- Doyen D
- Dres M
- Dreyer KR
- Dreyer KR
- Dunne ES
- Dupont H
- Duranteau J
- Dwyer R
- Démpaire G
- Ebeid A
- Elatrous S
- Elisabet GM
- Elkhayari M
- Ellis HE
- Elmasri M
- Erbabacan E
- Eriksson KE
- Esteban Andres
- Estenssoro E
- Esteve F
- Estilita JM
- Estrella CR
- Eugenio Luis PS
- Ezzouine H
- Fan E
- Fan Eddy
- Fartoukh M
- Farías PA
- Fawkes DA
- Ferguson A
- Ferguson ND
- Fernandez AM
- Fernandez RO
- Fierro JM
- Flores Mejia FJ
- Floris L
- Follin A
- Fontenele DC
- Formenti P
- Forteza C
- Fossali T
- Foti G
- Franco N
- Francois GM
- França AG
- Frati E
- Frendl G
- Frigyik AD
- Fusari M
- Futami S
- Gallego Curto E
- Gally J
- Ganesan D
- Gao Y
- Gao YN
- Garcia PH
- Gattinoni Luciano
- Gazenkampf AA
- Gelée B
- George FG
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin NK
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher EC
- Gomaa D
- Gomaa D
- Gomes RM
- Gomez PE
- Gomez-Flores SS
- Gonzalez DR
- Gonzalez M
- González Rojas MA
- González-Salamanca A
- Gonçalves CH
- Goodson JC
- Gordo F
- Gosselin RJ
- Goubaux B
- Graziani R
- Grelon F
- Griffin RO
- Grigoriev E
- Grissom CK
- Gritsan AI
- Grubissich N
- Gueret RM
- Gurjar M
- Guttormsen AB
- Guérin C
- Gómez PA
- Hacking DJ
- Haddad Y
- Hadfield D
- Hagan SJ
- Han H
- Han Y
- Hang AY
- Hanlon GC
- Harasawa T
- Harrois A
- Hashemian SM
- Hashemian SM
- Hashida T
- He Z
- Hedlund L
- Heidari F
- Heines SJ
- Helleberg J
- Henderson G
- Herbrecht JE
- Hermosa C
- Herrera Para L
- Hessell RJ
- Heunks LM
- Heunks LM
- Higashijima U
- Hirata A
- Holzgraefe B
- Honda H
- Honrubia T
- Hopf HF
- Hopkins P
- Hormis AP
- Hou PC
- Hou SK
- Hraiech S
- Hua MX
- Huang QQ
- Huang XB
- Huerta FP
- Huff NG
- Humphreys SK
- Hunt A
- Hurtado J
- Hurtado J
- Hurtado J
- Hutchison RA
- Hutton PJ
- Ibañez-Santacruz M
- Ichikado K
- Iglesias Moles S
- Ilutovich S
- Imai H
- Imma VP
- Imperio MC
- Insaurralde CS
- Inskip DM
- Ioannou N
- Iotti GA
- Irvine DA
- Ismail D
- Ismail M
- Ito F
- Izawa M
- Jaafar RF
- Jakubowska K
- Jamaati H
- Jarquin-Badiola YD
- Jassal M
- Javeed A
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- Zogheib EH
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- Publication venue
- 'American Thoracic Society'
- Publication date
- 01/01/2017
- Field of study
Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse. Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FIO2Berlin criteria is useful. Methods: TheLUNGSAFE(Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FIO2ratio in classifying patients receiving NIV, and the impact of NIV on outcome. MeasurementsandMain Results:Of2,813 patients with ARDS,436 (15.5%) were managed with NIV on Days 1 and 2 following fulfillment of diagnosticcriteria.Classification of ARDS severity based on PaO2/FIO2ratio was associated with an increase in intensity of ventilatory support, NIV failure, and intensive care unit (ICU) mortality. NIV failure occurred in 22.2% of mild, 42.3% of moderate, and 47.1% of patients with severe ARDS. Hospital mortality in patients with NIV success and failure was 16.1% and 45.4%, respectively. NIV use was independently associated with increased ICU (hazard ratio, 1.446 [95% confidence interval, 1.159-1.805]), but not hospital, mortality. In a propensity matched analysis, ICU mortality was higher in NIV than invasively ventilated patients with a PaO2/FIO2lower than 150 mm Hg. Conclusions:NIV was used in 15% of patients with ARDS,irrespective of severity category. NIV seems to be associated with higher ICU mortality in patients with a PaO2/FIO2lower than 150 mm Hg