Parental brain: cerebral areas activated by infant cries and faces. A comparison between different populations of parents and not.

Literature about parenting traditionally focused on caring behaviors and parental representations. Nowadays, an innovative line of research, interested in evaluating the neural areas and hormones implicated in the nurturing and caregiving responses, has developed. The only way to permit a newborn to survive and grow up is to respond to his needs and in order to succeed it is necessary, \ufb01rst of all, that the adults around him understand what his needs are. That is why adults\u2019 capacity of taking care of infants cannot disregard from some biological mechanisms, which allow them to be more responsive to the progeny and to infants in general. Many researches have proved that exist speci\ufb01c neural basis activating in response to infant evolutionary stimuli, such as infant cries and infant emotional facial expression. There is a sort of innate predisposition in human adults to respond to infants\u2019 signals, in order to satisfy their need and allow them to survive and become young adults capable of taking care of themselves. This article focuses on research that has investigated, in the last decade, the neural circuits underlying parental behavioral responses. Moreover, the paper compares the results of those studies that investigated the neural responses to infant stimuli under different conditions: familiar versus unknown children, parents versus non-parents and normative versus clinical samples (depression, addiction, adolescence, and PTSD)

Maternal Drug Addiction: Influences on mother-child relationship and on early child development.

Much literature has pointed out parental drug addiction as a risk factor at multiple levels for the dyad, affecting parenting quality, child development and more globally the adult-child relationship. Drug addicted mothers are often reported as less sensitive, more intrusive and less able to regulate negative affects during early adult-child interactions. On the other hand, children of addicted mothers are often described as more irritable or more passive. The aim of this research was to investigate longitudinally the quality of adult-child relationship and of child interactive and emotional development in a group of drug addicted mothers and their children prenatally exposed to substances. The study involved 25 mother-child pairs (with children aged between 2 and 24 months) with drug addicted mothers. The dyads were followed for a 15 months-period and assessed regularly (every 3 months) through the application of the Emotional Availability Scales (EAS \u2013 Biringen, 2008) to videotaped free play interactions. In this way it has been possible to consider both the mothers\u2019 and the children\u2019s contribution to the development of their relationship. The results were controversial, showing on one hand changes related only to specific EA dimensions and on the other hand patterns of changes that seemed characteristics of specific patterns of emotional availability. Dyads that initially showed interactions of better quality tended to improve their relationship during time, whereas dyads that exhibited more difficulties at the beginning of the study did not show improvements. Moreover, children of dyads which experienced interactions of better quality showed better interactive and emotional features than children of dyads characterized by more dysfunctional patterns of interaction. Dyads characterized by maternal drug addiction are often reported to be at higher risk for experiencing difficulties during everyday interactions and more likely to be associated to less optimal developmental outcomes. Anyway the results of our study highlight that, despite the condition of drug addiction, experiencing a relationship of good quality could be associated to better mother-child interactions and to more functional interactive and emotional development for children

Attachment representations and early interactions in drug addicted mothers: a case study of four women with distinct Adult Attachment Interview classifications

open4Drug addiction is considered a major risk factor that can influence maternal functioning at multiple levels, leading to less optimal parental qualities and less positive interactive exchanges in mother-child dyads. Moreover, drug abusers often report negative or traumatic attachment representations regarding their own childhood. These representations might affect, to some extent, later relational and developmental outcomes of their children. This study explored whether the development of dyadic interactions in addicted women differed based on attachment status. The longitudinal ongoing of mother-child emotional exchanges was assessed among four mothers with four different attachment statuses (F-autonomous, E-preoccupied, Ds-dismissing, and U-unresolved/with losses). Attachment representations were assessed using the Adult Attachment Interview ( George et al., 1985), while mother-child interactions were evaluated longitudinally during videotaped play sessions, through the Emotional Availability Scales (Biringen, 2008). As expected, the dyad with the autonomous mother showed better interactive functioning during play despite the condition of drug-abuse; the mother proved to be more affectively positive, sensitive, and responsive, while her baby showed a better organization of affects and behaviors. On the other side,insecure mothers seemed to experience more difficulties when interacting with their children showing inconsistency in the ability to perceive and respond to their babies’ signals. Finally, children of insecure mothers showed less clear affects and signals. While differences between secure and insecure dyads appeared clear, differences between insecure patterns where less linear, suggesting a possible mediating role played by other factors. Clinical implications and suggestions for future research are discussed.openPorreca, A.; De Palo, F.; Simonelli, A.; Capra, N.Porreca, Alessio; DE PALO, Francesca; Simonelli, Alessandra; Capra, N

Sexual orientation and drive: a comparative pilot study on sexual desire

Many studies addressing sexual drive and hypersexuality stated that homosexuals are used to report higher levels of sexual desire and compulsive sexual behaviors. Literature showed a lack of comparisons between perceived level of desire in hetero and gay population. This study aims to analyze some variables which could predict levels of sexual desire in both heterosexual and homosexual men such as sexual satisfaction, distress, sexism and dysfunctional sexual beliefs

Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art

Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits. The cardioprotective effects of several foods and dietary supplements in both animal models and in humans have been explored. It was found that beneficial effects are mainly dependent on antioxidant and anti-inflammatory properties, also involving modulation of mitochondrial function. Resveratrol is one of the most studied phytochemical compounds and it is provided with several benefits in cardiovascular diseases as well as in other pathological conditions (such as cancer). Other relevant compounds are Brassica oleracea, curcumin, and berberine, and they all exert beneficial effects in several diseases. In the attempt to provide a comprehensive reference tool for both researchers and clinicians, we summarized in the present paper the existing literature on both preclinical and clinical cardioprotective effects of each mentioned phytochemical. We structured the discussion of each compound by analyzing, first, its cellular molecular targets of action, subsequently focusing on results from applications in both ex vivo and in vivo models, finally discussing the relevance of the compound in the context of human diseases

The Role of Father Involvement and Marital Satisfaction in the Development of Family Interactive Abilities: A Multilevel Approach.

The study aims to investigate the development of family interactions from pregnancy to preschool age in a longitudinal perspective, using multilevel analysis. Also, it explored the impact of couple relationship and father involvement in childcare on the developmental trend of the quality of mother\u2013father\u2013child interactions. One hundred and three primiparous families were assessed at 7th month of pregnancy, 4th, 9th, and 18th months of child\u2019s life and during preschool age (36\u201348th), using the observational procedure named, Lausanne Trilogue Play. Parents\u2019 perception of marital satisfaction was assessed with the Dyadic Adjustment Scale at each point of measure; moreover, in the postnatal assessment, parents completed the Father Involvement Questionnaire. Results showed that family interactions increase over time. Secondly, a decrease of marital adjustment is associated with an improvement of the quality of family interactions. Moreover, father involvement predicts the quality of family interactions from the earliest stages of child\u2019s life. In a longitudinal perspective, family interactions and marital quality show opposite developmental trends and father\u2019s involvement represents a particularly important feature of the family

Pupillometric analysis for assessment of gene therapy in Leber Congenital Amaurosis patients

Background: Objective techniques to assess the amelioration of vision in patients with impaired visual function are needed to standardize efficacy assessment in gene therapy trials for ocular diseases. Pupillometry has been investigated in several diseases in order to provide objective information about the visual reflex pathway and has been adopted to quantify visual impairment in patients with Leber Congenital Amaurosis (LCA). In this paper, we describe detailed methods of pupillometric analysis and a case study on three Italian patients affected by Leber Congenital Amaurosis (LCA) involved in a gene therapy clinical trial at two follow-up time-points: 1 year and 3 years after therapy administration. Methods: Pupillary light reflexes (PLR) were measured in patients who had received a unilateral subretinal injection in a clinical gene therapy trial. Pupil images were recorded simultaneously in both eyes with a commercial pupillometer and related software. A program was generated with MATLAB software in order to enable enhanced pupil detection with revision of the acquired images (correcting aberrations due to the inability of these severely visually impaired patients to fixate), and computation of the pupillometric parameters for each stimulus. Pupil detection was performed through Hough Transform and a non-parametric paired statistical test was adopted for comparison. Results: The developed program provided correct pupil detection also for frames in which the pupil is not totally visible. Moreover, it provided an automatic computation of the pupillometric parameters for each stimulus and enabled semi-automatic revision of computerized detection, eliminating the need for the user to manually check frame by frame. With reference to the case study, the amplitude of pupillary constriction and the constriction velocity were increased in the right (treated eye) compared to the left (untreated) eye at both follow-up time-points, showing stability of the improved PLR in the treated eye. Conclusions: Our method streamlined the pupillometric analyses and allowed rapid statistical analysis of a range of parameters associated with PLR. The results confirm that pupillometry is a useful objective measure for the assessment of therapeutic effect of gene therapy in patients with LCA

Psycho-relational well-being in women with sexual pain: a preliminary study

Female sexual pain is a complex multi-factorial condition. Most of the research has focused on underlying biomedical factors. Although psychological and relational factors have been studied as possible correlates, data are still controversial. The aim of the present study was to investigate psychological and relational well-being in women who complain of sexual pain. The hypothesis was that sexual pain is associated with worse scores

Research and Intervention for Drug-Addicted Mothers and Their Children: New Perspectives

According to research carried out by the EMCDDA, drug-addicted women in Europe account for at least one quarter of the total European population consuming illicit substances (Emcdda, 2006a). A specific research platform entitled \u201cWomen and Drugs\u201d was created within the context of the second European project \u201cDemocracies, Cities and Drugs.\u201d This platform is focused on what characterizes and distinguishes female substance addiction from male substance addiction: its manifestation, its attributes, and the interventions or services which can be put into effect while devoting special attention and offering specialized care to this phenomenon. Our findings confirm that women substance users are exposed to a great number of risks such as medical, social, economic, familial and psychopathological risks requiring intervention through specific tools and aimed responses (see Brentari, Hernandez, Tripodi, 2011). The investigated factors included pregnancy, parenthood and the well-being as well as development of the child, while taking into account institutional and ethical reflections regarding this complex theme. The substance abuse phenomenon indeed affects a high number of fertile women. When drugs are consumed during pregnancy, they can have serious, direct and indirect effects on the postpartum development with subsequent effects on the child (OTIS, 2010). Substance abusing mothers represent an at-risk parenting situation which, in turn, profoundly influences the quality of the mother-child relationship. The awareness of these at-risk situations for children along with the widely accepted notion that ideally, children should always be raised by their mothers led to the introduction of residential treatment in Italy. These services deal with maternal pathologies and provide care and assistance for children; in fact, these therapeutic communities accommodate addicted mothers as well as their children. Up until recently, therapies for children (particularly medical ones) were administered by institutions outside of the community, while no therapeutic treatment was mandated for minors. The first therapeutic communities for drug addicted mothers and their children appeared in Europe in the early nineties. These institutions must provide assistance to children and assure them the greatest possible social, psychological and physical well-being. In addition to the funds available for each mother, funds for each individual minor are made available on a daily basis. Our project: \u201cResearch and intervention on minors in communities for addicted mothers and their children: from at-risk parenting to child wellbeing\u201d was promoted within this specific intervention framework. The project aims to secure child well-being by assessing maternal parenting as well as by carrying out direct and indirect observations of the child, his/her caregivers and the caregiver-child relationship. At the same time, the most suitable intervention for each single subject is put into effect

Extraversion and neuroticism in sexually dysfunctional men suffering from erectile dysfunction and premature ejaculation: a cross-sectional study

The role of personality traits in sexual complaints and dysfunctions is ever more evident. However, the literature is very scarce as to the possible relationships between such personality traits and specific sexual dysfunctions like ED, PE or both, their subtypes as to time of onset and severity levels. The main aim of the present study was to investigate if Neuroticism and Extraversion have different roles and trends in men suffering from PE and/or ED, both lifelong and acquired. Moreover, we verified if, by adopting DSM-IV-TR and DSM-5 criteria for diagnosing PE, some differences emerged in percentages of diagnosed cases. The sample consisted of 222 patients aged 18-70. The International Index of Erectile Function (IIEF-15) was used to assess erectile function, and the Premature Ejaculation Severity Index (PESI) was used to assess the severity of PE dysfunction. Neuroticism and Extraversion were measured with the Eysenck Personality Questionnaire-Revised (EPQ-R). In our results, Neuroticism and Extraversion were dependent on the kind of sexual dysfunction and its severity. These results suggest that type, time of onset and severity of sexual dysfunctions should be considered as related to specific personality characteristics and vice versa