76 research outputs found
Impact of Rhabdomyosarcoma (RMS) Characteristics on Prognosis of Pediatric RMS: a SEER Database Large Population Study
To provide a better insight into the epidemiology, characteristics, therapeutics, and outcomes of pediatric RMS. Data of 1,623 pediatric RMS were acquired from the Surveillance, Epidemiology and End Results (SEER) database. Detailed information on demographics, primary site, size, subtype, stage, surgery, and survival had been recorded during 1975-2016. The most common subtype was embryonal RMS (64.9%) followed by alveolar RMS (29.9%). Additionally, the majority of RMS size was larger than 5 cm. Multivariable analysis exhibited that the age over 10, unfavorable primary site, distant metastasis was respectively correlated with the poor OS, whereas surgery could improve the outcomes of pediatric RMS. In conclusion, our large population-based analysis described that age, subtype, primary tumor sites, stage and surgery are all independent prognosis factors for RMS
Advancing Medical Imaging with Language Models: A Journey from N-grams to ChatGPT
In this paper, we aimed to provide a review and tutorial for researchers in
the field of medical imaging using language models to improve their tasks at
hand. We began by providing an overview of the history and concepts of language
models, with a special focus on large language models. We then reviewed the
current literature on how language models are being used to improve medical
imaging, emphasizing different applications such as image captioning, report
generation, report classification, finding extraction, visual question
answering, interpretable diagnosis, and more for various modalities and organs.
The ChatGPT was specially highlighted for researchers to explore more potential
applications. We covered the potential benefits of accurate and efficient
language models for medical imaging analysis, including improving clinical
workflow efficiency, reducing diagnostic errors, and assisting healthcare
professionals in providing timely and accurate diagnoses. Overall, our goal was
to bridge the gap between language models and medical imaging and inspire new
ideas and innovations in this exciting area of research. We hope that this
review paper will serve as a useful resource for researchers in this field and
encourage further exploration of the possibilities of language models in
medical imaging
High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome
Differential expression of microRNAs (miRNAs) has been implicated in leukemogenesis. We investigate
the ex- pression pattern of miR-196b. Using quantitative real-time PCR (qRT-PCR), we detected the
expression of miR- 196b and its correlated genes (SMC1A/MLH1) in initial pediatric AML. A significant association was observed between overexpression of miR-196b and inferior overall
survival of pediatric AML (Log Rank P<0.0001). AML M4/5 subtype, high white blood cell (WBC) count
at presentation, MLL rearrangement, or FLT3-ITD mutation at diagnosis and non-remission group after
the first induction chemotherapy possessed higher miR-196b expression. Furthermore, a positive
relationship was found between the expression of miR-196b and SMC1A/MLH1 (Spear- man’s r=0.37 and
0.44, P=0.001 and <0.0001, respectively). Taken together, these findings suggest that differen-
tially high expression of miR-196b in diagnostic marrow samples of pediatric AML is associated with
unfavorable outcome, and miR-196b potentially can be a novel biomarker for the diagnosis, prognosis
and treatment in pediatric AML
In vivo total or partial hepatectomy followed by ex vivo liver resection and autotransplantation for malignant tumors: a single center experience
BackgroundEx vivo liver resection and autotransplantation (ELRAT) may provide an opportunity for R0 resection of conventionally unresectable hepatobiliary cancers and hepatic metastases. To date, few studies of the surgery for malignant tumors have been conducted and there are no known reports of in vivo partial hepatectomy followed by ELRAT (IPH-ELRAT) for malignant tumors.MethodsBetween December 2021 and November 2022, ten patients with malignant hepatobiliary primary cancers or hepatic metastases underwent ELRAT at our institution. We shared the surgical skills and postoperative prognoses of these patients were assessed.ResultsThe types of tumors were biliary tract cancer (BTC, n=8), hepatic metastasis of colonic carcinoma (n=1), and hepatic metastasis of small-bowel stromal tumor (n=1). Five patients underwent in vivo total hepatectomy followed by ex vivo liver resection and autotransplantation (ITH-ELRAT), The other five received in vivo partial hepatectomy followed by ex vivo liver resection and autotransplantation (IPH-ELRAT). Four patients underwent inferior vena cava replacement using artificial blood vessels. The survival rate of all ten patients one month after surgery was 100%. Nine patients (90%) are currently alive, with a median follow-up of 8.5 months (range 6–16.5 months). To date, seven of the nine surviving patients have had no cancer recurrence, including six with BTC.ConclusionsWe report the world first five cases that received IPH-ELRAT for malignancies. We also demonstrated relatively favorable outcomes in patients who underwent ELRAT. ELRAT may be a recommendable surgical option for selected patients with conventionally unresectable hepatobiliary malignant tumors
On the Road with GPT-4V(ision): Early Explorations of Visual-Language Model on Autonomous Driving
The pursuit of autonomous driving technology hinges on the sophisticated
integration of perception, decision-making, and control systems. Traditional
approaches, both data-driven and rule-based, have been hindered by their
inability to grasp the nuance of complex driving environments and the
intentions of other road users. This has been a significant bottleneck,
particularly in the development of common sense reasoning and nuanced scene
understanding necessary for safe and reliable autonomous driving. The advent of
Visual Language Models (VLM) represents a novel frontier in realizing fully
autonomous vehicle driving. This report provides an exhaustive evaluation of
the latest state-of-the-art VLM, GPT-4V(ision), and its application in
autonomous driving scenarios. We explore the model's abilities to understand
and reason about driving scenes, make decisions, and ultimately act in the
capacity of a driver. Our comprehensive tests span from basic scene recognition
to complex causal reasoning and real-time decision-making under varying
conditions. Our findings reveal that GPT-4V demonstrates superior performance
in scene understanding and causal reasoning compared to existing autonomous
systems. It showcases the potential to handle out-of-distribution scenarios,
recognize intentions, and make informed decisions in real driving contexts.
However, challenges remain, particularly in direction discernment, traffic
light recognition, vision grounding, and spatial reasoning tasks. These
limitations underscore the need for further research and development. Project
is now available on GitHub for interested parties to access and utilize:
\url{https://github.com/PJLab-ADG/GPT4V-AD-Exploration
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KIF21A Mutations in Two Chinese Families with Congenital Fibrosis of the Extraocular Muscles (CFEOM)
Purpose: Two Chinese families (XT and YT) with congenital fibrosis of the extraocular muscles (CFEOM) were identified. The purpose of this study was to determine if previously described Homo sapiens kinesin family member 21A (KIF21A) mutations were responsible for CFEOM in these two Chinese pedigrees. Methods: Clinical characterization and genetic studies were performed. Microsatellite genotyping for linkage to the CFEOM1 and CFEOM3 loci was performed. The probands were screened for KIF21A mutations by bidirectional direct sequencing. Once a mutation was detected in the proband, all other participating family members and 100 unrelated control normal individuals were screened for the mutation. Results: All affected individuals in family XT shared the common manifestations of CFEOM1. Family YT had two affected individuals, a mother and a daughter. The daughter had CFEOM1, while her mother never had congential ptosis but did have limited extraocular movements status post strabismus surgery. Haplotype analysis revealed that pedigree XT was linked to the 12q CFEOM1 locus and the affected memberes harbored the second most common missense mutation in KIF21A (2,861G>A, R954Q). Family YT harbored the most common missense de novo mutation in KIF21A (2,860C>T, R954W). Both of these mutations have been previously described. Conclusions: The observation of these two KIF21A mutations in a Chinese pedigree underscores the homogeneity of these mutations as a cause of CFEOM1 and CFEOM3 across ethnic divisions
The influence of methotrexate-related transporter and metabolizing enzyme gene polymorphisms on peri-engraftment syndrome and graft-versus-host disease after haplo-hematopoietic stem cell transplantation in pediatric patients with malignant hematological diseases
BackgroundMethotrexate (MTX), utilized as a graft-versus-host disease (GvHD) prophylactic agent in allogeneic hematopoietic stem cell transplantation (allo-HSCT), has been proven to effectively decrease the occurrence of the peri-engraftment syndrome (Peri-ES) and acute GvHD (aGvHD). Changes in the pharmacodynamics of MTX are closely associated with gene polymorphisms in genes encoding drug-metabolizing enzymes and transporters. Nevertheless, the current studies mainly concentrate on leukemia or autoimmune diseases, and limited studies on allo-HSCT were reported.MethodsHere, we retrospectively assessed the relationship between MTX-related transporter and metabolizing enzyme gene polymorphisms, clinical characteristics, and outcomes in 57 pediatric patients who received haploid HSCT (haplo-HSCT) with malignant tumors at a single center.ResultsWe discovered all gene polymorphisms were in the Hardy–Weinberg equilibrium in our cohort. We discovered a significant correlation between platelet recovery time and ABCB1 (1236C>T) (p = 0.042). Compared with patients with SLCO1B1 (1865+4846T>C) TT, patients with SLCO1B1 (1865+4846T>C) TC/CC had an increased incidence of Peri-ES (p = 0.030). Based on the multivariate Cox analysis, we discovered that SLCO1B1 (1865+4846T>C) TT genotype was an independent protective factor for Peri-ES morbidity (hazard ratio (HR) = 0.464, p = 0.031), and the dose of mononuclear cells reinfused was significantly correlated with II–IV aGvHD (HR = 2.604, p = 0.039).ConclusionIn summary, our findings prove that the host’s genotypes might modify the risk of developing Peri-ES, contribute to a better understanding of the inter-individual difference in efficacy, and facilitate the development of individualized approaches to GvHD prophylaxis
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