2,311 research outputs found
Enabling Adaptive Grid Scheduling and Resource Management
Wider adoption of the Grid concept has led to an increasing amount of federated
computational, storage and visualisation resources being available to scientists and
researchers. Distributed and heterogeneous nature of these resources renders most of the
legacy cluster monitoring and management approaches inappropriate, and poses new
challenges in workflow scheduling on such systems. Effective resource utilisation monitoring
and highly granular yet adaptive measurements are prerequisites for a more efficient Grid
scheduler. We present a suite of measurement applications able to monitor per-process
resource utilisation, and a customisable tool for emulating observed utilisation models. We
also outline our future work on a predictive and probabilistic Grid scheduler. The research is
undertaken as part of UK e-Science EPSRC sponsored project SO-GRM (Self-Organising
Grid Resource Management) in cooperation with BT
Understanding the Student with Asperger Syndrome
Children diagnosed with Asperger syndrome present a special challenge in the educational milieu. This article provides teachers with descriptions of seven defining characteristics of Asperger syndrome, in addition to suggestions and strategies for addressing these symptoms in the classroom. Behavioral and academic interventions based on the author's teaching experiences with children with Asperger syndrome are offered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68244/2/10.1177_108835769501000202.pd
Self-organising management of Grid environments
This paper presents basic concepts, architectural principles and algorithms for efficient resource and security management in cluster computing environments and the Grid. The work presented in this paper is funded by BTExacT and the EPSRC project SO-GRM (GR/S21939)
Cosmic Calibration: Constraints from the Matter Power Spectrum and the Cosmic Microwave Background
Several cosmological measurements have attained significant levels of
maturity and accuracy over the last decade. Continuing this trend, future
observations promise measurements of the statistics of the cosmic mass
distribution at an accuracy level of one percent out to spatial scales with
k~10 h/Mpc and even smaller, entering highly nonlinear regimes of gravitational
instability. In order to interpret these observations and extract useful
cosmological information from them, such as the equation of state of dark
energy, very costly high precision, multi-physics simulations must be
performed. We have recently implemented a new statistical framework with the
aim of obtaining accurate parameter constraints from combining observations
with a limited number of simulations. The key idea is the replacement of the
full simulator by a fast emulator with controlled error bounds. In this paper,
we provide a detailed description of the methodology and extend the framework
to include joint analysis of cosmic microwave background and large scale
structure measurements. Our framework is especially well-suited for upcoming
large scale structure probes of dark energy such as baryon acoustic
oscillations and, especially, weak lensing, where percent level accuracy on
nonlinear scales is needed.Comment: 15 pages, 14 figure
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Apolipoprotein E in VLDL and LDL With Apolipoprotein CâIII is Associated With a Lower Risk of Coronary Heart Disease
Background: Lowâdensity lipoprotein (LDL) with apolipoprotein CâIII (apoCâIII) is the lipoprotein species that most strongly predicts initial and recurring coronary heart disease (CHD) events in several cohorts. Thus, a large portion of the CHD risk conferred by LDL may be attributable to LDL that contains apoCâIII. Veryâlowâdensity lipoprotein (VLDL) and LDL with apoCâIII have varying amounts of apoE. We hypothesized that a high content of apoE lessens the adverse influence of apoCâIII on the risk of CHD because it promotes the clearance of VLDL and LDL from plasma. Methods and Results: We studied 2 independent cohorts, the Nurses' Health Study, composed of women, and the Health Professionals Followâup Study, composed of men. These cohorts contributed to this study 322 women and 418 men initially free of CVD who developed a fatal or nonfatal myocardial infarction during 10 to 14 years of followâup and matched controls who remained free of CHD. The apoE content of LDL with apoCâIII was inversely associated with CHD after multivariable adjustment (relative risk for top versus bottom quintile 0.53, 95% CI 0.35 to 0.80). The apoE content of VLDL with apoCâIII had a similar inverse association with CHD. The highest risks were associated with a high apoB concentration and a low apoE content of LDL with apoCâIII or of VLDL+LDL with apoCâIII. The observed associations were in both male and female cohorts and independent of traditional CHD risk factors and of Câreactive protein. Conclusions: An increased apoE content in VLDL and LDL with apoCâIII was associated with a lower risk of CHD. Strategies to enrich VLDL and LDL in apoE are worth exploring for the prevention of CHD
Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania
Hybrid genotypes have been repeatedly described among natural isolates of Leishmania, and the recovery of experimental hybrids from sand flies co-infected with different strains or species of Leishmania has formally demonstrated that members of the genus possess the machinery for genetic exchange. As neither gamete stages nor cell fusion events have been directly observed during parasite development in the vector, we have relied on a classical genetic analysis to determine if Leishmania has a true sexual cycle. Here, we used whole genome sequencing to follow the chromosomal inheritance patterns of experimental hybrids generated within and between different strains of L. major and L. infantum. We also generated and sequenced the first experimental hybrids in L. tropica. We found that in each case the parental somy and allele contributions matched the inheritance patterns expected under meiosis 97â99% of the time. The hybrids were equivalent to F1 progeny, heterozygous throughout most of the genome for the markers that were homozygous and different between the parents. Rare, non-Mendelian patterns of chromosomal inheritance were observed, including a gain or loss of somy, and loss of heterozygosity, that likely arose during meiosis or during mitotic divisions of the progeny clones in the fly or culture. While the interspecies hybrids appeared to be sterile, the intraspecies hybrids were able to produce backcross and outcross progeny. Analysis of 5 backcross and outcross progeny clones generated from an L. major F1 hybrid, as well as 17 progeny clones generated from backcrosses involving a natural hybrid of L. tropica, revealed genome wide patterns of recombination, demonstrating that classical crossing over occurs at meiosis, and allowed us to construct the first physical and genetic maps in Leishmania. Altogether, the findings provide strong evidence for meiosis-like sexual recombination in Leishmania, presenting clear opportunities for forward genetic analysis and positional cloning of important genes.</div
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