32 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Automated classification of solid renal masses on contrast-enhanced computed tomography images using convolutional neural network with decision fusion
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- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Type 1 papillary renal cell carcinoma: differentiation from Type 2 papillary RCC on multiphasic MDCT
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Benign mesenchymal tumors of the abdomen
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Preoperative loco-regional staging of invasive lobular carcinoma with contrast-enhanced digital mammography (CEDM)
- Author
- A Fiorentino
- A Goldhirsch
- A Kalovidouri
- Anne-julie Carin
- BK Patel
- BK Patel
- C Boetes
- Catherine Depretto
- CI Li
- CJACR D’Orsi
- D Bernardi
- DJ Hilleren
- Donatello Cirone
- E Luczynska
- EM Fallenberg
- Ermanno Vanzi
- Federica Di Naro
- Francesco Amato
- G Arpino
- G Bicchierai
- G Kanyilmaz
- Gianfranco Scaperrotta
- Giulia Bicchierai
- Giulia Bicchierai
- GN Rodenko
- IV Gruber
- Jacopo Nori
- JM Bland
- K Schelfout
- KN Krecke
- M Le Gal
- M Macchini
- M Thomas
- M Zanotel
- MA Francescone
- MA Marino
- MM Hobbs
- Monica Iorfida
- MS Jochelson
- PJ Kneeshaw
- RF Brem
- RM Mann
- RM Mann
- RM Trimboli
- RS Butler
- S Fallahpour
- S Montemezzi
- SA Lee-Felker
- SP Weinstein
- Stephanie A Lee-Felker
- Terry K Koo
- Tommaso Vincenzo Bartolotta
- TV Bartolotta
- V Selvi
- Vittorio Miele
- WA Berg
- Y Zheng
- Yi-Zhou Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Quantitative multiparametric MR analysis of small renal lesions: correlation with surgical pathology
- Author
- A Volpe
- AA Razek
- AB Rosenkrantz
- AM Hotker
- B Taouli
- C Galmiche
- C Roy
- CA Karlo
- CL Siegel
- CW Yang
- DC Johnson
- EK Outwater
- F Agnello
- F Chen
- F Cornelis
- G Erbay
- H Mirka
- H Wang
- HC Thoeny
- HD Patel
- I Pedrosa
- JH Choi
- JJ Park
- JR Young
- K Sandrasegaran
- KS Jhaveri
- M Cova
- M Dhyani
- M Jinzaki
- M Notohamiprodjo
- MF Muller
- N Hindman
- PM Pierorazio
- RS Lim
- S Collins
- SA Lee-Felker
- SC Ha
- T Namimoto
- VE Reuter
- VG Bird
- X Yu
- Y Kim
- Y Zhong
- YY Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Management of end-stage heart failure: a perspective on the Arab Gulf states
- Author
- Abraham WT
- Al-Maeda
- Al-Nozha M
- Al-Nozha MM
- Al-Nozha MM
- Al-Nozha MM
- Al-Nozha MM
- Al-Nozha MM
- Al-Othaimeen AI
- Aurigemma GP
- Beyersdorf F
- Bourge RC
- Bristow MR
- Cadeiras M
- Chen JM
- Chen JM
- Cleland JG
- Cohn JN
- El-Shoubaki H
- Evans RW
- Felker GM
- Felker GM
- Fonarow GC
- Foody JM
- Garg R
- Garrick C. Stewart
- Gilbert H. Mudge
- Hauptman PJ
- Hunt SA
- Hunt SA
- Jarcho JA
- Jessup M
- Jessup M
- Josephson M
- Juurlink DN
- Kirklin JK
- Lee DS
- Levy WC
- Lietz K
- Lietz K
- Lietz K
- McAlister FA
- McMurray JJ
- Miller LW
- Miller LW
- Moskowitz AJ
- Mozaffarian D
- Mudge GH
- Nohria A
- Omran AR
- Packer M
- Pitt B
- Pitt B
- Portner PM
- Redfield MM
- Redfield MM
- Roger VL
- Rosamond W
- Rose EA
- Russo MJ
- Senni M
- Shaheen FA
- Shaheen FA
- Stevenson LW
- Stevenson LW
- Stevenson LW
- Stewart S
- Stromberg A
- Swedberg K
- Taylor AL
- Taylor DO
- Teuteberg JJ
- Waleed Al Habeeb
- Weber KT
- Westaby S
- Westaby S
- Wilson SR
- Wilson SR
- Young JB
- Young JB
- Young JB
- Publication venue
- Medknow Publications
- Publication date
- Field of study
The ever expanding epidemic of end-stage heart failure represents one of the greatest challenges of modern cardiovascular medicine. With medical treatments hampered by significant limitations, physicians caring for patients with advanced heart disease have turned to cardiac transplantation and durable mechanical circulatory assist devices as definitive therapies. These advanced therapeutic modalities are not widely available outside the United States and Europe, but nevertheless offer enormous potential for patients in the Arab Gulf suffering from end-stage heart failure. This review will discuss the management of end-stage heart failure in the Gulf States, with an emphasis on therapies best utilized within a framework of regional cooperation and coordination
Shape and texture-based radiomics signature on CT effectively discriminates benign from malignant renal masses
- Author
- A Traverso
- AH Davarpanah
- Assad A. Oberai
- Austin J. Fullenkamp
- B Bhindi
- B Zhao
- BA Varghese
- Bhushan Desai
- Bino A. Varghese
- Brian D. Quinn
- Christopher Lau
- CT Bektas
- Darryl H. Hwang
- EJ Limkin
- Felix Y. Yap
- FY Yap
- H Coy
- Inderbir S. Gill
- IS Gill
- J Ding
- J Shu
- Lindsay L. Yang
- Manju Aron
- Marielena Rivas
- Megha Nayyar Gupta
- Mihir M. Desai
- ML Blute
- Monish Aron
- NS Patel
- R Díaz-Uriarte
- R Yang
- RM Haralick
- SA Lee-Felker
- Simin Hajian
- Steven Y. Cen
- T Shin
- Vinay A. Duddalwar
- X He
- Xiaomeng Lei
- Z Feng
- Z-C Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chagas’ Disease: Update on Current Diagnosis
- Author
- A Peix
- A Rassi Jr
- A Rassi Jr
- A Rassi Jr
- A Rassi Jr
- A Regueiro
- AI Fiorelli
- Andréa Marinho Falcão
- AV Sarabanda
- C Mady
- CA Rochitte
- CE Rochitte
- D Rassi do C
- E Botvinick
- EA Bocchi
- EB Falchetto
- EM Tassi
- FJ Mancuso
- FW Torres
- H Rodríguez-Zanella
- HF Freitas
- J Chen
- JA Marin-Neto
- JA Marin-Neto
- JM Hagar
- JO Duarte
- JP Andrade
- KC Wu
- Marcelo L. Campos Vieira
- Maria Clementina Giorgi
- MC Nunes
- MC Nunes
- MF Carli Di
- MF Tsan
- ML Higuchi
- ML Vieira
- ML Vieira
- MM Barbosa
- MV Simões
- P Lancellotti
- PJ Hotez
- RJ Viotti
- RM Lang
- RM Lang
- RP Mello
- RT Hahn
- SA Lee-Felker
- SA Morris
- Salvador Borges-Neto
- SC Brandão
- SC Brandão
- VM Gimenes
- VT Hotta
- VT Hotta
- W Tsang
- WG Hundley
- William A. Chalela
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study