172 research outputs found
SuperIdentity: fusion of identity across real and cyber domains
Under both benign and malign circumstances, people now manage a spectrum of identities across both real-world and cyber domains. Our belief, however, is that all these instances ultimately track back for an individual to reflect a single âSuperIdentityâ. This paper outlines the assumptions underpinning the SuperIdentity Project, describing the innovative use of data fusion to incorporate novel real-world and cyber cues into a rich framework appropriate for modern identity. The proposed combinatorial model will support a robust identification or authentication decision, with confidence indexed both by the level of trust in data provenance, and the diagnosticity of the identity factors being used. Additionally, the exploration of correlations between factors may underpin the more intelligent use of identity information so that known information may be used to predict previously hidden information. With modern living supporting the âdistribution of identityâ across real and cyber domains, and with criminal elements operating in increasingly sophisticated ways in the hinterland between the two, this approach is suggested as a way forwards, and is discussed in terms of its impact on privacy, security, and the detection of threa
Search for Rare and Forbidden Dilepton Decays of the D+, Ds, and D0 Charmed Mesons
We report the results of a search for flavor-changing neutral current,
lepton-flavor violating, and lepton-number violating decays of D+, Ds, and D0
mesons (and their antiparticles) into modes containing muons and electrons.
Using data from Fermilab charm hadroproduction experiment E791, we examine the
pi,l,l and K,l,l decay modes of D+ and Ds and the l+l- decay modes of D0. No
evidence for any of these decays is found. Therefore, we present
branching-fraction upper limits at 90% confidence level for the 24 decay modes
examined. Eight of these modes have no previously reported limits, and fourteen
are reported with significant improvements over previously published results.Comment: 12 pages, 3 figures, LaTeX, elsart.cls, epsf.sty, amsmath.sty
Submitted to Physics Letters
Measurement of the form-factor ratios for D+ --> K* l nu
The form factor ratios rv=V(0)/A1(0), r2=A2(0)/A1(0) and r3=A3(0)/A1(0) in
the decay D+ --> K* l nu, K* -->K-pi+ have been measured using data from charm
hadroproduction experiment E791 at Fermilab. From 3034 (595) signal
(background) events in the muon channel, we obtain rv=1.84+-0.11+-0.09,
r2=0.75+-0.08+-0.09 and, as a first measurement of r3, we find 0.04+-0.33
+-0.29. The values of the form factor ratios rv and r2 measured for the muon
channel are combined with the values of rv and r2 that we have measured in the
electron channel. The combined E791 results for the muon and electron channels
are rv=1.87+-0.08+-0.07 and r2=0.73+-0.06+-0.08.Comment: 9 pages + 3 figures ; submitted to PL
Differential cross sections, charge production asymmetry, and spin-density matrix elements for D*(2010) produced in 500 GeV/c pi^- nucleon interactions
We report differential cross sections for the production of D*(2010) produced
in 500 GeV/c pi^- nucleon interactions from experiment E791 at Fermilab, as
functions of Feynman-x (x_F) and transverse momentum squared (p_T^2). We also
report the D* +/- charge asymmetry and spin-density matrix elements as
functions of these variables. Investigation of the spin-density matrix elements
shows no evidence of polarization. The average values of the spin alignment are
\eta= 0.01 +- 0.02 and -0.01 +- 0.02 for leading and non-leading particles,
respectively.Comment: LaTeX2e (elsart.cls). 13 pages, 6 figures (eps files). Submitted to
Physics Letters
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Search for electroweak production of single top quarks in collisions.
We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DZero detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process ppbar->tb+X of 39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb. (arXiv
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
Hard Single Diffraction in pbarp Collisions at root-s = 630 and 1800 GeV
Using the D0 detector, we have studied events produced in proton-antiproton
collisions that contain large forward regions with very little energy
deposition (``rapidity gaps'') and concurrent jet production at center-of-mass
energies of root-s = 630 and 1800 Gev. The fractions of forward and central jet
events associated with such rapidity gaps are measured and compared to
predictions from Monte Carlo models. For hard diffractive candidate events, we
use the calorimeter to extract the fractional momentum loss of the scattered
protons.Comment: 11 pages 4 figures. submitted to PR
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