Serotonin transporter gene 5-HTTLPR VNTR allele frequency distribution in Africa and Eurasia

The S allele frequencies of serotonin transporter gene 5-HTTLPR, which is associated with a number of psychiatric disorders, were found for 21 populations of Eurasia and Africa. The principal components of genetic variability (PC1 and PC2) based on the published frequencies for 68 alleles at five STR loci of CODIS, which are supposed to be neutral, were calculated for the same populations. The S allele frequency is correlated to PC2 (R = 0.820, p < 0.0001); this means that the correlation corresponds to the general genetic variability in the studied populations. The correlation between the STR allele frequency and Hofstede’s individualism-collectivism dimension index for 4 of the 68 studied alleles is even higher than the correlation of the S allele frequency. Our findings do not support the hypothesis (Chiao and Blizinsky, 2010) on the culture-gene coevolution of the S allele frequency and the level of collectivism. © 2016, Pleiades Publishing, Ltd

Serotonin transporter gene 5-HTTLPR VNTR allele frequency distribution in Africa and Eurasia

The S allele frequencies of serotonin transporter gene 5-HTTLPR, which is associated with a number of psychiatric disorders, were found for 21 populations of Eurasia and Africa. The principal components of genetic variability (PC1 and PC2) based on the published frequencies for 68 alleles at five STR loci of CODIS, which are supposed to be neutral, were calculated for the same populations. The S allele frequency is correlated to PC2 (R = 0.820, p < 0.0001); this means that the correlation corresponds to the general genetic variability in the studied populations. The correlation between the STR allele frequency and Hofstede’s individualism-collectivism dimension index for 4 of the 68 studied alleles is even higher than the correlation of the S allele frequency. Our findings do not support the hypothesis (Chiao and Blizinsky, 2010) on the culture-gene coevolution of the S allele frequency and the level of collectivism. © 2016, Pleiades Publishing, Ltd

Allele frequency distributions of -174G/C polymorphism in regulatory region of interleukin 6 gene (IL6) in Russian and worldwide populations

Allele and genotype frequencies of the -174G/C polymorphism (rs1800795) in the regulatory region of the IL6 gene, which encode anti-inflammatory cytokine interleukin 6, were determined in seven populations representing five ethnic groups from the European part of Russia (440 individuals), as well as in small cohorts that represent populations from 24 countries of Africa and Eurasia (365 individuals). The maps of the geographic distribution of the -174G/C allele frequencies were constructed based on personal (22 populations) and the literature data (66 populations), and the data from dbSNP database obtained by the HapMap project (10 populations). The frequency of the -174G allele varied from 45 to 100% and was characterized by nonrandom geographic distribution. These data could reflect the adaptive load of the alleles examined, which was different in different regions of the world. It is suggested that the level of pathogen prevalence is one of the environmental factors that determine different adaptive values of the IL6*-174G/C alleles. This suggestion is supported by a positive correlation between the -174G allele frequency and level of pathogen prevalence calculated based on historical data (R = 0. 768; p & 0. 0001). © 2013 Pleiades Publishing, Ltd

Allele frequency distributions of -174G/C polymorphism in regulatory region of interleukin 6 gene (IL6) in Russian and worldwide populations

Allele and genotype frequencies of the -174G/C polymorphism (rs1800795) in the regulatory region of the IL6 gene, which encode anti-inflammatory cytokine interleukin 6, were determined in seven populations representing five ethnic groups from the European part of Russia (440 individuals), as well as in small cohorts that represent populations from 24 countries of Africa and Eurasia (365 individuals). The maps of the geographic distribution of the -174G/C allele frequencies were constructed based on personal (22 populations) and the literature data (66 populations), and the data from dbSNP database obtained by the HapMap project (10 populations). The frequency of the -174G allele varied from 45 to 100% and was characterized by nonrandom geographic distribution. These data could reflect the adaptive load of the alleles examined, which was different in different regions of the world. It is suggested that the level of pathogen prevalence is one of the environmental factors that determine different adaptive values of the IL6*-174G/C alleles. This suggestion is supported by a positive correlation between the -174G allele frequency and level of pathogen prevalence calculated based on historical data (R = 0. 768; p & 0. 0001). © 2013 Pleiades Publishing, Ltd

Polymorphism of the apolipoprotein e gene (APOE) in the populations of Russia and neighboring countries

Allele and genotype frequencies for the locus encoding apolipoprotein E, involved in the regulation of lipid metabolism (APOE), were evaluated in 16 populations representing 12 ethnic groups (a total of 1103 subjects) from Russia and neighboring countries. In the populations examined, the frequencies of allele 4, which is the risk factor of Alzheimer's disease and coronary heart disease, varied from less than 5 to more than 20%, while the variation of the major 3 allele in these populations ranged from less than 75 to 95%. The frequencies of alleles 3 and 4 were 0.714 and 0.205 in Saami, 0.735 and 0.220 in Komi-Izhemts, 0.770 and 0.130 in Komi-Zyryans, 0.771 and 0.149 in Udmurts, 0.734 and 0.149 in Maris, 0.841 and 0.122 in Evenks, 0.788 and 0.163 in Buryats, 0.764 and 0.202 in Chukchi, 0.875 and 0.075 in Iranians, 0.956 and 0.044 in mountain-dwellers of the Pamirs, 0.771 and 0.094 in Ukrainians, and 0.795 and 0.091 in Belarussians, respectively. In Russians from different regions of the country, the frequencies of these alleles were 0.728 and 0.139 (Kostroma), 0.795 and 0.105 (Moscow), 0.857 and 0.092 (Rostov-on-Don), and 0.824 and 0.083 (Krasnodar), respectively. The latitudinal distribution of the APOE 3 and 4 allele frequencies in the populations examined was comparable to the frequency distribution pattern of these alleles in other populations of Eurasia. © 2007 Pleiades Publishing, Inc