Particle identification for charmless two-body B decays at LHCb

Due to the possibility to produce $B^0$, $B_s^0$ and $\lambda_b$ hadrons in the proton-proton collisions at the LHC, the mass peaks of many two-body $B$ decays overlap. For this reason, the particle identification capabilities of the LHCb detector will play a crucial role in the measurements related to these decay modes. In this document we propose a method for combining different observables provided by the LHCb particle identification system into a single generalized discriminating variable, useful when performing the statistical separation of the various channels in event-by-event fits

The FIT-pull Method: an experimental tool to monitor the track measurements and the B proper time.

In this note we describe a statistical tool, the \textit{FIT-pull method}, that can test the reliability of the measurements of the tracks and the vertices on real and Monte-Carlo data without knowledge of the truth information. The basic mathematical formalism is derived from the Lagrange Multipliers method and briefly described. Several tests are performed to prove its validity in different situations. %KDifferent useful examples are discussed. In particular, by using Monte-Carlo simulation, we demonstrate that the method can be applied to check if the measured tracks or vertices have biases or incorrect covariance matrices. For correct input measurements we obtain pull distributions with a normal Gaussian statistical form. In this case the B proper time value and its error, which is a function of the track and vertex measurements, are correctly calculated. However, in the case of incorrect measurements, for example due to a systematic error or to a scale factor of the covariance matrix, the pull distributions studied deviate from normal Gaussians and the B proper time measurement can be affected. In principle the method can, if necessary, be used to recover information from corrupted measurements. Its potential in this capacity is demonstrated for the particular case of the decay channel $B^0_d \to \pi^+ \pi^-$ with the reconstructed Monte-Carlo data produced in 2004

Charmless charged two-body B decays at LHCb

In this note we summarize the status of the studies on charmless charged two-body B-meson decays at LHCb. LHCb has a great potential for triggering, reconstructing and selecting a huge number of such decays, increasing the available statistics from the B-factories and the Tevatron by more than one order of magnitude. First we will describe the selection algorithm ans its performance, then we will show how it is possible to get relevant information on the γ angle of the Unitarity Triangle and on the breaking of the U-spin symmetry using these decays

Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues

Meningiomas are the most common intracranial tumors. Most meningiomas are WHO grade 1 tumors whereas less than one-quarter of all meningiomas are classified as atypical (WHO grade 2) and anaplastic (WHO grade 3) tumors, based on local invasiveness and cellular features of atypia. Surgical resection remains the cornerstone of meningioma therapy and represents the definitive treatment for the majority of patients; however, grade 2 and grade 3 meningiomas display more aggressive behavior and are difficult to treat. Several retrospective series have shown the efficacy and safety of postoperative adjuvant external beam radiation therapy (RT) for patients with atypical and anaplastic meningiomas. More recently, two phase II prospective trials by the Radiation Therapy Oncology Group (RTOG 0539) and the European Organisation for Research and Treatment of Cancer (EORTC 2042) have confirmed the potential benefits of fractionated RT for patients with intermediate and high-risk meningiomas; however, several issues remain a matter of debate. Controversial topics include the timing of radiation treatment in patients with totally resected atypical meningiomas, the optimal radiation technique, dose and fractionation, and treatment planning/target delineation. Ongoing randomized trials are evaluating the efficacy of early adjuvant RT over observation in patients undergoing gross total resection. © 2022, The Author(s

Invariant mass line shape of B -> PP decays at LHCb

The family of B meson decays into pairs of charmless charged pseudo-scalar mesons comprises many different channels. In order to disentagle the overlapped mass peaks of the various decay modes, an accurate description of the invariant mass distribution of each mode is required. In particular, the invariant mass parameterization must take into account the effect of QED final state radiation, which leads to the presence of a long tail on the lower side of the mass peak. In this document we propose a new parameterization based on a complete QED calculation of the photon emission rate and we compare it to a simpler one based on phenomenological arguments. Furthermore, we show how the shape of the invariant mass distributions under the pi+pi- mass hypothesis, for every decay mode of interest, can be described very precisely by means of analytical calculations

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. Here, we show that siRNA-mediated loss of calsyntenin-1 in cultured neurons alters APP processing to increase production of Aβ. We also show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased Aβ levels. Calsyntenin-1 is a ligand for kinesin-1 light chains and APP is transported through axons on kinesin-1 molecular motors. Defects in axonal transport are an early pathological feature in Alzheimer's disease and defective APP transport is known to increase Aβ production. We show that calsyntenin-1 and APP are co-transported through axons and that siRNA-induced loss of calsyntenin-1 markedly disrupts axonal transport of APP. Thus, perturbation to axonal transport of APP on calsyntenin-1 containing carriers induces alterations to APP processing that increase production of Aβ. Together, our findings suggest that disruption of calsyntenin-1-associated axonal transport of APP is a pathogenic mechanism in Alzheimer's disease

From intensive care to rehabilitation: survey on the satisfaction with care received during prolonged hospitalization for COVID-19 at a northern Italian university hospital

Objective: Investigating the experiences perceived by COVID-19 inpatients is a fundamental research area that is starting to be explored. For this reason, our objective was to provide the first Italian survey on COVID-19 inpatients' satisfaction, obtained through a self-completed questionnaire previously used in a reference study in a UK cohort of COVID-19 patients. Subjects and methods: Hospitalized COVID-19 patients (>20 days) admitted to Ferrara University Hospital who underwent rehabilitation during their hospital stay were invited to complete an anonymous questionnaire. The survey's questions explored the patients' satisfaction with the health services received, and their completion took place approximately one year after hospitalization. Information on sex, number of wards, ICU stays, and hospital discharge dates was collected. Results: Sixty-two completed questionnaires were analyzed. The average overall satisfaction score obtained from the answers indicated by the participants in the tenth question was 4.7 out of 5.0. Very positive responses were observed for information about discharge plans, privacy, management of pain, sleep quality, and feeling of safety. The possibility of being consulted about medications and side effects received a very low satisfaction score. Considering overall satisfaction, no significant differences were noted for sex or ICU stay. The obtained results were almost superimposable to those reported in the cohort of COVID-19 patients of the reference study. Conclusions: This survey suggested that COVID-19 patients' healthcare satisfaction was high. Nevertheless, some areas must be improved, such as the communication and involvement of the patients in the decision-making of care and the discussion about medications or possible side effects

Quantum Gravity Effects in Black Holes at the LHC

We study possible back-reaction and quantum gravity effects in the evaporation of black holes which could be produced at the LHC through a modification of the Hawking emission. The corrections are phenomenologically taken into account by employing a modified relation between the black hole mass and temperature. The usual assumption that black holes explode around $1$TeV is also released, and the evaporation process is extended to (possibly much) smaller final masses. We show that these effects could be observable for black holes produced with a relatively large mass and should therefore be taken into account when simulating micro-black hole events for the experiments planned at the LHC.Comment: 14 pages, 8 figures, extended version of hep-ph/0601243 with new analysis of final products, final version accepted for publication in J. Phys.

Mini Black Holes in the first year of the LHC

The experimental signatures of TeV-mass black hole (BH) formation in heavy ion collisions at the LHC is examined. We find that the black hole production results in a complete disappearance of all very high $p_T$ ({$> 500$} GeV) back-to-back correlated di-jets of total mass {$M > M_f \sim 1$}TeV. We show that the subsequent Hawking-decay produces multiple hard mono-jets and discuss their detection. We study the possibility of cold black hole remnant (BHR) formation of mass $\sim M_f$ and the experimental distinguishability of scenarios with BHRs and those with complete black hole decay. Due to the rather moderate luminosity in the first year of LHC running the least chance for the observation of BHs or BHRs at this early stage will be by ionizing tracks in the ALICE TPC. Finally we point out that stable BHRs would be interesting candidates for energy production by conversion of mass to Hawking radiation.Comment: 10 pages, 2 figure