151 research outputs found
Magnetic field concentration with coaxial silicon nanocylinders in the optical spectral range
Resonant magnetic energy accumulation is theoretically investigated in the optical and near-infrared regions. It is demonstrated that the silicon nanocylinders with and without coaxial through holes can be used for the control and manipulation of optical magnetic fields, providing up to 26-fold enhancement of these fields for the considered system. Magnetic field distributions and dependence on the parameters of nanocylinders are revealed at the wavelengths of magnetic dipole and quadrupole resonances responsible for the enhancement. The obtained results can be applied, for example, to designing nanoantennas for the detection of atoms with magnetic optical transitions
In Vitro Cytotoxicity of CdSe/ZnS Quantum Dots and Their Interaction with Biological Systems
Semiconductor nanocrystals (quantum dots, QDs) have a wide range of potential application in multiplexed tissue and cell imaging, and for in vivo molecular diagnostics and therapy. Therefore studying of the toxicity of QDs and their influence on various cellular processes in vitro is necessary to understand their interaction with living systems.; The paper presents the results of studies on the evaluation of CdSe/ZnS QD cytotoxicity, as well as the results of studying their interaction with freshly prepared human monocytes in vitro.
Keywords: Quantum dots, semiconductor nanocrystals, cytotoxicity, in vitro models, monocytes
Cytotoxicity of Polyelectrolyte Microcapsules Encoded with Semiconductor Nanocrystals
Polyelectrolyte microcapsules are promising carriers of drugs and diagnostic agents for designing targeted and controlled delivery systems design. The use of quantum dots (QDs) as fluorescent labels in bioimaging is a promising approach to bioimaging tool development. The potential toxicity of QDs makes their applicability as fluorescent labels in vivo questionable. Therefore, the cytotoxicity of polyelectrolyte microcapsules encoded with semiconductor nanocrystals has been investigated.
Keywords: Polyelectrolyte microcapsules, semiconductor nanocrystals, cytotoxicity, theranostic agents
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Transmission and reflection features of all-dielectrics metasurfaces with electric and magnetic resonances
The effective multipole decomposition approach is applied to study the optical features of the silicon metasurface in the near-infrared. The spectral regions of perfect transmission and reflection have been analyzed using the Cartesian multipole decomposition. It is shown that transmission peaks appear due to the mutual interaction of multipole moments up to the third order, while reflection peaks are due to the dominant contribution of one of the multipole moments. The results of this work can be broadly applied to design novel metasurfaces, sensors, and optical filters.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Transverse scattering and generalized Kerker effects in all-dielectric Mie-resonant meta-optics
All-dielectric resonant nanophotonics lies at the heart of modern optics and
nanotechnology due to the unique possibilities to control scattering of light
from high-index dielectric nanoparticles and metasurfaces. One of the important
concepts of dielectric Mie-resonant nanophotonics is associated with the Kerker
effect that drives the unidirectional scattering of light from nanoantennas and
Huygens' metasurfaces. Here we suggest and demonstrate experimentally a novel
effect manifested in the nearly complete simultaneous suppression of both
forward and backward scattered fields. This effect is governed by the Fano
interference between an electric dipole and off-resonant quadrupoles, providing
necessary phases and amplitudes of the scattered fields to achieve the
transverse scattering. We extend this concept to dielectric metasurfaces that
demonstrate zero reflection with transverse scattering and strong field
enhancement for resonant light filtering, nonlinear effects, and sensing
КРИТЕРИИ ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ ТУБЕРКУЛЕЗА У ДЕТЕЙ В СОВРЕМЕННЫХ УСЛОВИЯХ
The main objective of a phthisiologist following up and treating children and adolescents with local forms of tuberculosis is to achieve complete clinical cure with minimal remaining post-tuberculosis changes. Evaluation of treatment progress is important since it defines not only the duration of chemotherapy and follow-up but it also serves a prognostic criterion of stable clinical cure and prevention of relapse in the future. New criteria for evaluation of tuberculosis activity and clinical cure in children and adolescents were assessed. It was proved that Mantoux test could not be the criterion of the disease activity. While results of the test with tuberculous recombinant allergen (TRA) performed at the moment of clinical cure did not depend on the volume and severity of changes and allowed assessing the activity of the disease with any intensity of specific changes in chest lymph nodes and lung tissue, and TRA test served as a criterion of activity of mycobacterial population in the host.Основной целью работы врача-фтизиатра в процессе диспансерного наблюдения и лечения детей и подростков с локальными формами туберкулеза является полноценное клиническое излечение с минимальными остаточными посттуберкулезными изменениями. Оценка динамики процесса на фоне проводимого лечения представляется важной, так как определяет не только длительность необходимого курса противотуберкулезной химиотерапии и диспансерного наблюдения, но и является прогностическим критерием для стойкого клинического излечения и отсутствия рецидива заболевания в дальнейшем. Проведена оценка новых критериев активности и клинического излечения туберкулеза у детей и подростков. Показано, что проба Манту не может являться критерием активности туберкулезного процесса. Напротив, результаты пробы с аллергеном туберкулезным рекомбинантным (АТР) на момент клинического излечения туберкулеза не зависят от объема и степени выраженности изменений и позволяют оценивать активность заболевания при любой выраженности специфических изменений во внутригрудных лимфатических узлах и легочной ткани, а значит, проба с АТР является критерием активности микробной популяции микобактерий туберкулеза в организме человека
Лучевые методы в диагностике и стадировании рака желудка
Purpose. To assess the possibilities of methods of radiation diagnosis in the recognition and staging of gastric cancer.Material and methods. The results of inspection of 307 patients with cancer of a stomach at which endoscopic, radiological and computer tomography researches on purpose, both primary diagnosis of gastric cancer, and establishment of a staging of process have been executed have been analyzed from 2014 to 2017.Results. At a radiological research proximal cancer of a stomach is revealed at 63 (20,5%) patients, a body – at 202 (65.8%) and distally – at 42 (13.7%) patients. In all cases we managed to diagnose precisely stomach cancer, its localization and distribution on stomach walls. MSCT allowed to determine the spread of the tumor beyond the organ. Results of comprehensive examination of patients with cancer of a stomach have allowed to stage the process. The first stage has been established at 40 (13.0%) patients, second – at the 117 (38.2%), third – at the 102 (33.2%), fourth – at 48 (15.6%). Of the 307 patients with gastric cancer, various types of interventions were subsequently performed in 254 (83%), chemotherapy, as an independent type of treatment was performed in 49 (16%), refused any treatment of 4 (1%) patients.Conclusion. Complex radiation diagnosis is highly informative for the detection and staging of stomach cancer.Цель исследования: оценить возможности лучевой диагностики в распознавании и стадировании рака желудка.Материал и методы. Проанализированы результаты обследования 307 больных раком желудка, у которых были выполнены эндоскопические, рентгенологические и компьютерно-томографические исследования с целью как первичной диагностики рака желудка, так и установления стадии процесса, пролеченных за период с 2014 по 2017 г.Результаты. При рентгенологическом исследовании проксимальный рак желудка выявлен у 63 (20,5%) больных, тела – у 202 (65,8%) и дистальный – у 42 (13,7%) больных. Во всех случаях нам удалось точно диагностировать рак желудка, установить его локализацию и распространение по стенкам желудка. МСКТ позволила определить распространение опухоли за пределы органа. В результате комплексного лучевого обследования больных раком желудка удалось установить стадию процесса. I стадия была выявлена у 40 (13,0%) больных, II – у 117 (38,2%), III – у 102 (33,2%), IV – у 48 (15,6%). Из 307 больных раком желудка в последующем были выполнены различные виды хирургических вмешательств у 254 (83%), химиотерапия, как самостоятельный вид лечения выполнялась у 49 (16%), отказались от какого-либо лечения, 4 (1%) больных.Заключение. Комплексная лучевая диагностика высокоинформативна для выявления и стадирования рака желудка
РОЛЬ ЛУЧЕВЫХ МЕТОДОВ В ДИАГНОСТИКЕ И СТАДИРОВАНИИ РАКА ПРЯМОЙ КИШКИ
Purpose: assessment of complex radiation diagnosis in the recognition and staging of rectal cancer.Material and methods. From 2016 for 2017 are examined 66 patients with rectum cancer. X-ray methods (irrigoscopy), MSCT and (or) MRI in combination with intravenous contrast enhancement were used as radiation methods.Results. Rectal cancer was detected in 66 patients. In the study, the upper ampullar part of the rectum was affected in 14 (21%) patients, the upper-middle-ampullar part in 2 (3%), the middle ampullar one in 26 (39%), the middle- lowera mpullar one in 3 (5%), the lower ampullary in 21 (32%). Results of inspection have allowed not only to establish defeat process, but also to specify his stage in compliance with TNM system. Stage I of the disease was established in 2 (3%) patients, stage II in 22 (33%), stage III in 25 (38%) and stage IV in 17 (26%). Subsequently, 39 (59%) patients were operated on.Conclusion. Complex radiation diagnosis made it possible to accurately diagnose and localize the tumor process, to establish intra – and extra organ distribution with the defeat of surrounding structures and organs. And finally, to make a choice in favor of this or that surgical intervention, and also to determine the necessity of its combination with chemoradiotherapy.Цель исследования: оценка комплексной лучевой диагностики в распознавании и стадировании рака прямой кишки.Материал и методы. За период с 2016 по 2017 г. обследовано 66 больных раком прямой кишки. Применяли рентгеновские методы исследования: ирригоскопия, МСКТ и/или МРТ в сочетании с внутривенным контрастным усилением.Результаты. Рак прямой кишки был выявлен у 66 больных. При исследовании верхнеампулярный отдел прямой кишки был поражен у 14 (21%) больных, верхнесреднеампулярный – у 2 (3%), среднеампулярный – у 26 (39%), средненижнеампулярный – у 3 (5%), нижнеампулярный – у 21 (32%). Результаты обследования позволили не только установить процесс поражения, но и уточнить его стадию в соответствии с классификацией TNM. I стадия заболевания установлена у 2 (3%) паци ентов, II стадия – у 22 (33%), III стадия – у 25 (38%) и IV стадия – у 17 (26%). В последующем 39 (59%) больных были прооперированы.Заключение. Комплексная лучевая диагностика позволила точно диагностировать и локализовать опухолевый процесс, установить внутри- и внеорганное его распространение с поражением окружающих структур и органов и в конечном итоге сделать выбор в пользу того или иного оперативного вмешательства, а также определить необходимость его сочетания с химиолучевой терапией
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