A two-fluid model for tissue growth within\ud a dynamic flow environment

We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture medium is driven. We employ a multiphase formulation of the type presented by G. Lemon, J. King, H. Byrne, O. Jensen and K. Shakesheff in their study (Multiphase modelling of tissue growth using the theory of mixtures. J. Math. Biol. 52(2), 2006, 571–594) restricted to two interacting fluid phases, representing a cell population (and attendant extracellular matrix) and a culture medium, and employ the simplifying limit of large interphase viscous drag after S. Franks in her study (Mathematical Modelling of Tumour Growth and Stability. Ph.D. Thesis, University of Nottingham, UK, 2002) and S. Franks and J. King in their study (Interactions between a uniformly proliferating tumour and its surrounding: Uniform material properties. Math. Med. Biol. 20, 2003, 47–89).\ud \ud The novel aspects of this study are: (i) the investigation of the effect of an imposed flow on the growth of the tissue construct, and (ii) the inclusion of a mechanotransduction mechanism regulating the response of the cells to the local mechanical environment. Specifically, we consider the response of the cells to their local density and the culture medium pressure. As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct. The model is analysed using analytic and numerical techniques, the results of which illustrate the potential use of the model to predict the dominant regulatory stimuli in a cell population

The Properties and Gaseous Environments of Powerful Classical Double Radio Galaxies

The properties of a sample of 31 very powerful classical double radio galaxies with redshifts between zero and 1.8 are studied. The source velocities, beam powers, ambient gas densities, total lifetimes, and total outflow energies are presented and discussed. The rate of growth of each side of each source were obtained using a spectral aging analysis. The beam power and ambient gas density were obtained by applying the strong shock jump conditions to the ends of each side of the source. The total outflow lifetime was obtained by applying the power-law relationship between the beam power and the total source lifetime derived elsewhere for sources of this type, and the total outflow energy was obtained by combining the beam power and the total source lifetime. Composite profiles were constructed by combining results obtained from each side of each source. The composite profiles indicate that the ambient gas density falls with distance from the central engine. The source velocities, beam powers, total lifetimes, and total energies seem to be independent of radio source size. This is consistent with the standard model in which each source grows at a roughly constant rate during which time the central engine puts out a roughly constant beam power. The fact that the total source lifetimes and energies are independent of radio source size indicates that the sources are being sampled at random times during their lifetimes.Comment: 7 pages, 5 figures, to appear in "Extragalactic Jets: Theory and Observation from Radio to Gamma Ray", eds. T. A. Rector and D. S. De Young, ASP conference series, Replaced version has minor textual correction

Spreading dynamics on spatially constrained complex brain networks

The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics and has been widely undertaken. Typically, however, networks employed in theoretical studies bear little relation to the spatial embedding or connectivity of the neural networks that they attempt to replicate. Here, we employ detailed neuroimaging data to define a network whose spatial embedding represents accurately the folded structure of the cortical surface of a rat brain and investigate the propagation of activity over this network under simple spreading and connectivity rules. By comparison with standard network models with the same coarse statistics, we show that the cortical geometry influences profoundly the speed of propagation of activation through the network. Our conclusions are of high relevance to the theoretical modelling of epileptic seizure events and indicate that such studies which omit physiological network structure risk simplifying the dynamics in a potentially significant way

Ytterbium-doped tantalum pentoxide waveguide lasers

We have demonstrated a Yb:Ta2O5 waveguide laser fabricated by RF magnetron sputtering on oxidised silicon. The waveguide laser was end-pumped with a laser diode at 977 nm and lasing was observed between 1015 and 1020 nm. The launched pump power threshold and slope efficiency were measured to be ~25 mW and 1.78 %, respectively

Quasars, their host galaxies, and their central black holes

We present the final results from our deep HST imaging study of the hosts of radio-quiet quasars (RQQs), radio-loud quasars (RLQs) and radio galaxies (RGs). We describe new WFPC2 R-band observations for 14 objects and model these images in conjunction with the data already reported in McLure et al (1999). We find that spheroidal hosts become more prevalent with increasing nuclear luminosity such that, for nuclear luminosities M_V < -23.5, the hosts of both radio-loud and radio-quiet AGN are virtually all massive ellipticals. Moreover we demonstrate that the basic properties of these hosts are indistinguishable from those of quiescent, evolved, low-redshift ellipticals of comparable mass. This result kills any lingering notion that radio-loudness is determined by host-galaxy morphology, and also sets severe constraints on evolutionary schemes which attempt to link low-z ULIRGs with RQQs. Instead, we show that our results are as expected given the relationship between black-hole and spheroid mass established for nearby galaxies, and apply this relation to estimate the mass of the black hole in each object. The results agree very well with completely-independent estimates based on nuclear emission-line widths; all the quasars in our sample have M(bh) > 5 x 10^8 solar masses, while the radio-loud objects are confined to M(bh) > 10^9 solar masses. This apparent mass-threshold difference, which provides a natural explanation for why RQQs outnumber RLQs by a factor of 10, appears to reflect the existence of a minimum and maximum level of black-hole radio output which is a strong function of black-hole mass. Finally, we use our results to estimate the fraction of massive spheroids/black-holes which produce quasar-level activity. This fraction is \~0.1% at the present day, rising to > 10% at z = 2-3.Comment: Revised version accepted for publication in Monthly Notices of the Royal Astronomical Society. 46 pages, the final 19 of which comprise an Appendix. 15 figures in main text. A further 14 4-panel greyscale plots and 14 line plots which appear in the Appendix have been reproduced here with reduced quality due to space limitations. A full resolution copy of the manuscript can be obtained via ftp://ftp.roe.ac.uk/pub/jsd/dunlop2002.ps.g

Extended emission around GPS radio sources

Extended radio emission detected around a sample of GHz Peaked Spectrum (GPS) radio sources is discussed. Evidence for extended emission which is related to the GPS source is found in 6 objects out of 33. Three objects are associated with quasars with core-jet pc-scale morphology, and three are identified with galaxies with symmetric (CSO) radio morphology. We conclude that the core-jet GPS quasars are likely to be beamed objects with a continuous supply of energy from the core to the kpc scale. It is also possible that low surface brightness extended radio emission is present in other GPS quasars but the emission is below our detection limit due to the high redshifts of the objects. On the other hand, the CSO/galaxies with extended large scale emission may be rejuvenated sources where the extended emission is the relic of previous activity. In general, the presence of large scale emission associated with GPS galaxies is uncommon, suggesting that in the context of the recurrent activity model, the time scale between subsequent bursts is in general longer than the radiative lifetime of the radio emission from the earlier activity.Comment: 18 paged, 18 figures, accepted for publication on A&