Mechanisms of tissue injury in lupus nephritis

Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients

Charged spin 1/2 particle in an arbitrary magnetic field in two spatial dimensions: a supersymmetric quantum mechanical system

It is shown that the 2 X 2 matrix Hamiltonian describing the dynamics of a charged spin 1/2 particle with g-factor 2 moving in an arbitrary, spatially dependent, magnetic field in two spatial dimensions can be written as the anticommuator of a nilpotent operator and its hermitian conjugate. Consequently, the Hamiltonians for the two different spin projections form partners of a supersymmetric quantum mechanical system. The resulting supersymmetry algebra can then be exploited to explicitly construct the exact zero energy ground state wavefunction for the system. Modulo this ground state, the remainder of the eigenstates and eigenvalues of the two partner Hamiltonians form positive energy degenerate pairs. We also construct the spatially asymptotic form of the magnetic field which produces a finite magnetic flux and associated zero energy normalizable ground state wavefunction.Comment: 10 pages, LaTe

The Rolling Tachyon Boundary Conformal Field Theory on an Orbifold

We consider the non-trivial boundary conformal field theory with exactly marginal boundary deformation. In recent years this deformation has been studied in the context of rolling tachyons and S-branes in string theory. Here we study the problem directly from an open string point of view, at one loop. We formulate the theory of the Z_2 reflection orbifold. To do so, we extend fermionization techniques originally introduced by Polchinski and Thorlacius. We also explain how to perform the open string computations at arbitrary (rational) radius, by consistently constructing the corresponding shift orbifold, and show in what sense these are related to known boundary states. In a companion paper, we use these results in a cosmological context involving decaying branes.Comment: 23 page

Fractional S-branes on a Spacetime Orbifold

Unstable D-branes are central objects in string theory, and exist also in time-dependent backgrounds. In this paper we take first steps to studying brane decay in spacetime orbifolds. As a concrete model we focus on the R^{1,d}/Z_2 orbifold. We point out that on a spacetime orbifold there exist two kinds of S-branes, fractional S-branes in addition to the usual ones. We investigate their construction in the open string and closed string boundary state approach. As an application of these constructions, we consider a scenario where an unstable brane nucleates at the origin of time of a spacetime, its initial energy then converting into energy flux in the form of closed strings. The dual open string description allows for a well-defined description of this process even if it originates at a singular origin of the spacetime.Comment: 22 pages, 6 eps figure

Dark solitons in holographic superfluids

5 pages, Revtex, 5 figures, some typos corrected. Reference addedWe construct dark soliton solutions in a holographic model of a relativistic superfluid. We study the length scales associated with the condensate and the charge density depletion, and find that the two scales differ by a non-trivial function of the chemical potential. By adjusting the chemical potential, we study the variation of the depletion of charge density at the interface.Peer reviewe

Holographic metals at finite temperature

A holographic dual description of a 2+1 dimensional system of strongly interacting fermions at low temperature and finite charge density is given in terms of an electron cloud suspended over the horizon of a charged black hole in asymptotically AdS spacetime. The electron star of Hartnoll and Tavanfar is recovered in the limit of zero temperature, while at higher temperatures the fraction of charge carried by the electron cloud is reduced and at a critical temperature there is a second order phase transition to a configuration with only a charged black hole. The geometric structure implies that finite temperature transport coefficients, including the AC electrical conductivity, only receive contributions from bulk fermions within a finite band in the radial direction.Comment: LaTex 16 pages, 12 figures, v2: Added reference. Error in free energy corrected. Phase transition to AdS-RN black brane is third order rather than second order as was claimed previousl

Winding effects on brane/anti-brane pairs

We study a brane/anti-brane configuration which is separated along a compact direction by constructing a tachyon effective action which takes into account transverse scalars. Such an action is relevant in the study of HQCD model of Sakai and Sugimoto of chiral symmetry breaking, where the size of the compact circle sets the confinement scale. Our approach is motivated by string theory orbifold constructions and gives a route to model inhomogeneous tachyon decay. We illustrate the techniques involved with a relatively simple example of a harmonic oscillator on a circle. We will then repeat the analysis for the Sakai-Sugimoto model and show that by integrating out the winding modes will provide us with a renormalized action with a lower energy than that of truncating to zero winding sector.Comment: 21 pages, 3 figures. v3: discussion and references added, published versio