136 research outputs found
Nonsteady condensation and evaporation waves
We study motion of a phase transition front at a constant temperature between
stable and metastable states in fluids with the universal Van der Waals
equation of state (which is valid sufficiently close to the fluid's critical
point). We focus on a case of relatively large metastability and low viscosity,
when it can be shown analytically that no steadily moving phase-transition
front exists. Numerically simulating a system of the one-dimensional
Navier-Stokes and continuity equations, we find that, in this case, the
nonsteady phase-transition front emits acoustic shocks in forward and backward
directions. Through this mechanism, the front drops its velocity and eventually
comes to a halt. The acoustic shock wave may shuttle, bouncing elastically from
the system's edge and strongly inelastically from the phase transition front.
Nonsteady rarefaction shock waves appear in the shuttle process, despite the
fact that the model does not admit steady rarefaction waves propagating between
stationary states. If the viscosity is below a certain threshold, an
instability sets in, driving the system into a turbulent state. This work was
supported by the Japan Society for Promotion of Science.Comment: revtex text file and four eps files with figures. Physical Review
Letters, in pres
The thermal conductivity of the spin-1/2 XXZ chain at arbitrary temperature
Motivated by recent investigations of transport properties of strongly
correlated 1d models and thermal conductivity measurements of quasi 1d magnetic
systems we present results for the integrable spin-1/2 chain. The thermal
conductivity of this model has , i.e. it is infinite for zero frequency . The weight
of the delta peak is calculated exactly by a lattice path
integral formulation. Numerical results for wide ranges of temperature and
anisotropy are presented. The low and high temperature limits are studied
analytically.Comment: 12 page
Heat transport by lattice and spin excitations in the spin chain compounds SrCuO_2 and Sr_2CuO_3
We present the results of measurements of the thermal conductivity of the
quasi one-dimensional spin S=1/2 chain compound SrCuO_2 in the temperature
range between 0.4 and 300 K along the directions parallel and perpendicular to
the chains. An anomalously enhanced thermal conductivity is observed along the
chains. The analysis of the present data and a comparison with analogous recent
results for Sr_2CuO_3 and other similar materials demonstrates that this
behavior is generic for cuprates with copper-oxygen chains and strong
intrachain interactions. The observed anomalies are attributed to the
one-dimensional energy transport by spin excitations (spinons), limited by the
interaction between spin and lattice excitations. The energy transport along
the spin chains has a non-diffusive character, in agreement with theoretical
predictions for integrable models.Comment: 12 pages (RevTeX), 8 figure
Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of cellular responses including survival, activation, differentiation and proliferation and are now recognised to have a key role in a number of physiological and pathophysiological processes in the lung. PI-3Ks contribute to the pathogenesis of asthma by influencing the proliferation of airways smooth muscle and the recruitment of eosinophils, and affect the balance between the harmful and protective responses in pulmonary inflammation and infection by the modulation of granulocyte recruitment, activation and apoptosis. In addition they also seem to exert a critical influence on the malignant phenotype of small cell lung cancer. PI-3K isoforms and their downstream targets thus provide novel therapeutic targets for intervention in a broad spectrum of respiratory diseases
Thermal conductivity via magnetic excitations in spin-chain materials
We discuss the recent progress and the current status of experimental
investigations of spin-mediated energy transport in spin-chain and spin-ladder
materials with antiferromagnetic coupling. We briefly outline the central
results of theoretical studies on the subject but focus mainly on recent
experimental results that were obtained on materials which may be regarded as
adequate physical realizations of the idealized theoretical model systems. Some
open questions and unsettled issues are also addressed.Comment: 17 pages, 4 figure
Effects of nanosuspension and inclusion complex techniques on the in vitro protease inhibitory activity of naproxen
This study investigated the effects of nanosuspension and inclusion complex techniques on in vitro trypsin inhibitory activity of naproxen—a member of the propionic acid derivatives, which are a group of antipyretic, analgesic, and non-steroidal anti-inflammatory drugs. Nanosuspension and inclusion complex techniques were used to increase the solubility and anti-inflammatory efficacy of naproxen. The evaporative precipitation into aqueous solution (EPAS) technique and the kneading methods were used to prepare the nanosuspension and inclusion complex of naproxen, respectively. We also used an in vitro protease inhibitory assay to investigate the anti-inflammatory effect of modified naproxen formulations. Physiochemical properties of modified naproxen formulations were analyzed using UV, IR spectra, and solubility studies. Beta-cyclodextrin inclusion complex of naproxen was found to have a lower percentage of antitryptic activity than a pure nanosuspension of naproxen did. In conclusion, nanosuspension of naproxen has a greater anti-inflammatory effect than the other two tested formulations. This is because the nanosuspension formulation reduces the particle size of naproxen. Based on these results, the antitryptic activity of naproxen nanosuspension was noteworthy; therefore, this formulation can be used for the management of inflammatory disorders
Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study
BACKGROUND: Increasing evidence from epidemiologic studies suggest that oxidative stress may play a role in adult glioma. In addition to dietary antioxidants, antioxidant and weak estrogenic properties of dietary phytoestrogens may attenuate oxidative stress. Our hypothesis is that long-term consumption of dietary antioxidants and phytoestrogens such as genistein, daidzein, biochanin A, formononetin, matairesinol, secoisolariciresinol and coumestrol, may reduce the risk of adult glioma. METHODS: Using unconditional logistic regression models, we compared quartiles of consumption for several specific antioxidants and phytoestrogens among 802 adult glioma cases and 846 controls from two study series from the San Francisco Bay Area Adult Glioma Study, 1991 – 2000, controlling for vitamin supplement usage, age, socioeconomic status, gender, ethnicity and total daily calories. For cases, dietary information was either self-reported or reported by a proxy. For controls, dietary information was self-reported. Gender- and series- specific quartiles of average daily nutrient intake, estimated from food-frequency questionnaires, were computed from controls. RESULTS: Significant p-values (trend test) were evaluated using significance levels of either 0.05 or 0.003 (the Bonferroni corrected significance level equivalent to 0.05 adjusting for 16 comparisons). For all cases compared to controls, statistically significant inverse associations were observed for antioxidant index (p < 0.003), carotenoids (alpha- and beta-carotene combined, p < 0.05), daidzein (p = 0.003), matairesinol (p < 0.05), secoisolariciresinol (p < 0.003), and coumestrol (p < 0.003). For self-reported cases compared to controls, statistically significant inverse associations were observed for antioxidant index (p < 0.05) and daidzein (p < 0.05). CONCLUSION: Our results support inverse associations of glioma with higher dietary antioxidant index and with higher intake of certain phytoestrogens, especially daidzein
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