460,277 research outputs found
Bioaffinity detection of pathogens on surfaces
The demand for improved technologies capable of rapidly detecting pathogens with high sensitivity and selectivity in complex environments continues to be a significant challenge that helps drive the development of new analytical techniques. Surface-based detection platforms are particularly attractive as multiple bioaffinity interactions between different targets and corresponding probe molecules can be monitored simultaneously in a single measurement. Furthermore, the possibilities for developing new signal transduction mechanisms alongside novel signal amplification strategies aremuchmore varied. In this article, we describe some of the latest advances in the use of surface bioaffinity detection of pathogens. Three major sections will be discussed: (i) a brief overview on the choice of probe molecules such as antibodies, proteins and aptamers specific to pathogens and surface attachment chemistries to immobilize those probes onto various substrates, (ii) highlighting examples among the current generation of surface biosensors, and (iii) exploring emerging technologies that are highly promising and likely to form the basis of the next generation of pathogenic sensors
Communication, coordination and networks
We study experimentally how the network structure and length of pre-play communication affect behavior and outcome in a multi-player coordination game with
conflicting preferences. Network structure matters but the interaction between network and time effects is more subtle. Under each time treatment, substantial variations are observed in both the rate of coordination and distribution of coordinated outcomes across networks. But, increasing the communication length improves both efficiency and equity of coordination. In all treatments, coordination is mostly explained by convergence in communication. We also identify behaviors that explain
variations in the distribution of coordinated outcomes both within and across networks
Effect of Diethylenetriamine and Triethylamine sensitization on the critical diameter of Nitromethane
In this work, the critical diameter for detonation was measured for Nitromethane (NM) sensitized with two different amines: Diethylenetriamine (DETA) and Triethylamine (TEA). The critical diameter in glass and polyvinylchloride tubes is found to decrease rapidly as the amount of sensitizer is increased, then increase past a critical amount of sensitizer. Thus the critical diameter reaches a minimum at a critical concentration of sensitizer. It was also found that the critical diameter is lower with DETA than with TEA
Thermal Model and Optimization of a Large Crystal Detector using a Metallic Magnetic Calorimeter
We established a simple thermal model of the heat flow in a large crystal
detector designed for a neutrinoless double beta decay experiment. The detector
is composed of a CaMoO crystal and a metallic magnetic calorimeter (MMC).
The thermal connection between the absorber and the sensor consists of a gold
film evaporated on the crystal surface and gold bonding wires attached to this
film and the MMC sensor. The model describes athermal and thermal processes of
heat flow to the gold film. A successive experiment based on optimization
calculations of the area and thickness of the gold film showed a significant
improvement in the size and rise-time of the measured signals
Zero-temperature resistive transition in Josephson-junction arrays at irrational frustration
We use a driven Monte Carlo dynamics in the phase representation to determine
the linear resistivity and current-voltage scaling of a two-dimensional
Josephson-junction array at an irrational flux quantum per plaquette. The
results are consistent with a phase-coherence transition scenario where the
critical temperature vanishes. The linear resistivity is nonzero at any finite
temperatures but nonlinear behavior sets in at a temperature-dependent
crossover current determined by the thermal critical exponent. From a dynamic
scaling analysis we determine this critical exponent and the thermally
activated behavior of the linear resistivity. The results are in agreement with
earlier calculations using the resistively shunted-junction model for the
dynamics of the array. The linear resistivity behavior is consistent with some
experimental results on arrays of superconducting grains but not on wire
networks, which we argue have been obtained in a current regime above the
crossover current.Comment: 7 pages, 5 figures, to appear in Phys. Rev.
c-axis Raman Scattering in MgB2: Observation of a Dirty-Limit Gap in the pi-bands
Raman scattering spectra from the ac-face of thick MgB2 single crystals were
measured in zz, xz and xx polarisations. In zz and xz polarisations a threshold
at around 29 cm^{-1} forms in the below Tc continuum but no pair-breaking peak
is seen, in contrast to the sharp pair-breaking peak at around 100 cm^{-1} seen
in xx polarisation. The zz and xz spectra are consistent with Raman scattering
from a dirty superconductor while the sharp peak in the xx spectra argues for a
clean system. Analysis of the spectra resolves this contradiction, placing the
larger and smaller gap magnitudes in the sigma and pi bands, and indicating
that relatively strong impurity scattering is restricted to the pi bands.Comment: Revised manuscript accepted for publication in Physical Review
Letter
Shock and vibration response of multistage structure
Study of the shock and vibration response of a multistage structure employed analytically, lumped-mass, continuous-beam, multimode, and matrix-iteration methods. The study was made on the load paths, transmissibility, and attenuation properties along a longitudinal axis of a long, slender structure with increasing degree of complexity
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