525 research outputs found
Study of RPC gas mixtures for the ARGO-YBJ experiment
The ARGO-YBJ experiment consists of a RPC carpet to be operated at the
Yangbajing laboratory (Tibet, P.R. China), 4300 m a.s.l., and devoted to the
detection of showers initiated by photon primaries in the energy range 100 GeV
- 20 TeV. The measurement technique, namely the timing on the shower front with
a few tens of particles, requires RPC operation with 1 ns time resolution, low
strip multiplicity, high efficiency and low single counting rate. We have
tested RPCs with many gas mixtures, at sea level, in order to optimize these
parameters. The results of this study are reported.Comment: 6 pages, 3 figures. To be published in Nucl. Instr. Meth. A, talk
given at the "5th International Workshop on RPCs and Related Detectors", Bari
(Italy) 199
Future aspects of X-ray emission from crystal undulators at channeling of positrons
In connection with ideas to produce undulator-like radiation in the hundreds of keV up to the MeV region by means of positron and electron channeling, there is renewed interest to study various channeling phenomena also experimentally. With electrons experiments have been performed at the Mainz Microtron MAMI to explore channeling-radiation emission by a 4-period epitaxially grown strained
layer Si1−xGex undulator with a period length of λu = 9.9 μm. Unfortunately, high-quality positron beams of sufficient intensity are not easily accessible. The only serious candidate in Europe seems to be the Beam Test Facility (BTF) at INFN/LNF, Frascati, Italy. Some requirements to extent BTF in a facility which is also well suited for positron channeling-radiation experiments will be outlined
A model of population dynamics of TB in a prison system and application to South Africa
BACKGROUND: Tuberculosis (TB) continues to spread in South African prisons in particular, as prisons are over-capacitated
and have poor ventilation. The awaiting trial detainees are not screened on admission and are at high risk of
getting infected with TB.
RESULTS: We propose a compartmental model to describe the population dynamics of TB disease in prisons. Our
model considers the inflow of susceptible, exposed and TB infectives into the prison population. Removal of individuals
out of the prison population can be either by death or by being released from prison, as compared to a general
population in which removal is only by death. We describe conditions, including non-inflow of infectives into the
prison, which will ensure that TB can be eradicated from the prison population. The model is calibrated for the South
African prison system, by using data in existing literature. The model can be used to make quantitative projections
of TB prevalence and to measure the effect of interventions. Illustrative simulations in this regard are presented. The
model can be used for other prison populations too, if data is available to calculate the model parameters.
CONCLUSIONS: Various simulations generated with our model serve to illustrate how it can be utilized in making future
projections of the levels of prevalence of TB, and to quantify the effect of interventions such as screening, treatment
or reduction of transmission parameter values through improved living conditions for inmates. This makes it particularly
useful as there are various targets set by the World Health Organization and by governments, for reduction of
TB prevalence and ultimately its eradication. Towards eradication of TB from a prison system, the theorem on global
stability of the disease-free state is a useful indicator
Particle acoustic detection in gravitational wave aluminum resonant antennas
The results on cosmic rays detected by the gravitational antenna NAUTILUS
have motivated an experiment (RAP) based on a suspended cylindrical bar, which
is made of the same aluminum alloy as NAUTILUS and is exposed to a high energy
electron beam. Mechanical vibrations originate from the local thermal expansion
caused by warming up due to the energy lost by particles crossing the material.
The aim of the experiment is to measure the amplitude of the fundamental
longitudinal vibration at different temperatures. We report on the results
obtained down to a temperature of about 4 K, which agree at the level of about
10% with the predictions of the model describing the underlying physical
process.Comment: RAP experiment, 16 pages, 7 figure
First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother. A case study
Background Breast cancer represents the most frequent neoplasm diagnosed in women of childbearing age. When the tumour is oestrogen receptor-positive, tamoxifen is among the recommended endocrine treatments. Lactating women are advised not to breastfeed while receiving tamoxifen. However, information about tamoxifen transfer into breast milk is lacking. Methods We measured the concentration of tamoxifen and its metabolites by liquid chromatography-tandem mass spectrometry in the milk of a nursing mother that was treated for pregnancy-associated breast cancer diagnosed a few months after delivery. She was advised not to breastfeed her child and she collected milk samples for 23 days while the baby was fed with formula. Results Tamoxifen concentrations in milk increased reaching a maximum of 214 nM. The two active metabolitesZ-4-hydroxy-tamoxifen and Z-endoxifen, could not be quantified in milk the first days after tamoxifen intake, but increased over time and reached clinically significant levels after day 18. Conclusion This study demonstrates for the first time in human that tamoxifen and its metabolites transfer into milk. Since tamoxifen has a complete oral bioavailability, a long half-life (>7 days) and may interfere with the normal development of the infant, mothers should not breastfeed during tamoxifen treatment
Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred to as meiosis I and II). While sister kinetochores bind to microtubules emanating from opposite spindle poles during mitosis, they bind to microtubules originating from the same spindle pole during meiosis I. This phenomenon is referred to as mono-orientation and is essential for setting up the reductional mode of chromosome segregation during meiosis I. In budding yeast, mono-orientation depends on a four component protein complex referred to as monopolin which consists of two nucleolar proteins Csm1 and Lrs4, meiosis-specific protein Mam1 of unknown function and casein kinase Hrr25. Monopolin complex binds to kinetochores during meiosis I and prevents bipolar attachments. Although monopolin associates with kinetochores during meiosis I, its binding site(s) on the kinetochore is not known and its mechanism of action has not been established. By carrying out an imaging-based screen we have found that the MIND complex, a component of the central kinetochore, is required for monopolin association with kinetochores during meiosis. Furthermore, we demonstrate that interaction of monopolin subunit Csm1 with the N-terminal domain of MIND complex subunit Dsn1, is essential for both the association of monopolin with kinetochores and for monopolar attachment of sister kinetochores during meiosis I. As such this provides the first functional evidence for a monopolin-binding site at the kinetochore
Heat Transfer and Thermal Energy Storage Enhancement by Foams and Nanoparticles
The use of innovative methods for the design of heating, cooling, and heat storage devices has been mainly oriented in the last decade toward the use of nanofluids, metal foams coupled with working fluids, or phase change materials (PCMs). A network of nine Italian universities achieved significant results and innovative ideas on these topics by developing a collaborative project in the last four years, where different approaches and investigation techniques were synergically employed. They evaluated the quantitative extent of the enhancement in the heat transfer and thermal performance of a heat exchanger or thermal energy storage system with the combined use of nanofluids, metal foams, and PCMs. The different facets of this broad research program are surveyed in this article. Special focus is given to the comparison between the mesoscopic to macroscopic modeling of heat transfer in metal foams and nanofluids, as well as to the experimental data collected and processed in the development of the research
A novel method for the absolute fluorescence yield measurement by AIRFLY
One of the goals of the AIRFLY (AIR FLuorescence Yield) experiment is to
measure the absolute fluorescence yield induced by electrons in air to better
than 10% precision. We introduce a new technique for measurement of the
absolute fluorescence yield of the 337 nm line that has the advantage of
reducing the systematic uncertainty due to the detector calibration. The
principle is to compare the measured fluorescence yield to a well known process
- the Cerenkov emission. Preliminary measurements taken in the BFT (Beam Test
Facility) in Frascati, Italy with 350 MeV electrons are presented. Beam tests
in the Argonne Wakefield Accelerator at the Argonne National Laboratory, USA
with 14 MeV electrons have also shown that this technique can be applied at
lower energies.Comment: presented at the 5th Fluorescence Workshop, El Escorial - Madrid,
Spain, 16 - 20 September 200
The Air Microwave Yield (AMY) experiment - A laboratory measurement of the microwave emission from extensive air showers
The AMY experiment aims to measure the microwave bremsstrahlung radiation
(MBR) emitted by air-showers secondary electrons accelerating in collisions
with neutral molecules of the atmosphere. The measurements are performed using
a beam of 510 MeV electrons at the Beam Test Facility (BTF) of Frascati INFN
National Laboratories. The goal of the AMY experiment is to measure in
laboratory conditions the yield and the spectrum of the GHz emission in the
frequency range between 1 and 20 GHz. The final purpose is to characterise the
process to be used in a next generation detectors of ultra-high energy cosmic
rays. A description of the experimental setup and the first results are
presented.Comment: 3 pages -- EPS-HEP'13 European Physical Society Conference on High
Energy Physics (July, 18-24, 2013) at Stockholm, Swede
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