2,863 research outputs found
Ion-Optical Design of the High-Resolution Mass Separator for the Japanese Hadron Project (IV)
開始ページ、終了ページ: 冊子体のページ付
Ion-Optical Design of a Pilot Separator for the JHP-ISOL
開始ページ、終了ページ: 冊子体のページ付
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Measured mechanical properties of superconducting-coil materials and their influence on coil prestress
Some measured thermal-mechanical characteristics of a film-insulated, superconducting, Rutherford-type flat cable are presented. Loads are applied, and strains measured, perpendicular to the wide face of the conductor, corresponding to the circumferential direction in a dipole magnet. Stress-strain-time behavior at room temperature during cooldown, and at 77 K, with some data at 4 K, are presented. Properties were greatly improved by holding the insulated conductor at 100C for 4 hr while under a compressive stress of 15 kpsi
Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis.
UNLABELLED: Persistent human cytomegalovirus (HCMV) infection has been linked to several diseases, including atherosclerosis, transplant vascular sclerosis (TVS), restenosis, and glioblastoma. We have previously shown that factors secreted from HCMV-infected cells induce angiogenesis and that this process is due, at least in part, to increased secretion of interleukin-6 (IL-6). In order to identify the HCMV gene(s) responsible for angiogenesis promotion, we constructed a large panel of replication-competent HCMV recombinants. One HCMV recombinant deleted for UL1 to UL10 was unable to induce secretion of factors necessary for angiogenesis. Fine mapping using additional HCMV recombinants identified UL7 as a viral gene required for production of angiogenic factors from HCMV-infected cells. Transient expression of pUL7 induced phosphorylation of STAT3 and ERK1/2 MAP kinases and production of proangiogenic factors, including IL-6. Addition of recombinant pUL7 to cells was sufficient for angiogenesis and was again associated with increased IL-6 expression. Analysis of the UL7 structure revealed a conserved domain similar to the immunoglobulin superfamily domain and related to the N-terminal V-like domain of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Our report therefore identifies UL7 as a novel HCMV-encoded molecule that is both structurally and functionally related to cellular CEACAM1, a proangiogenic factor highly expressed during vasculogenesis. IMPORTANCE: A hallmark of cytomegalovirus (CMV) infection is its ability to modulate the host cellular machinery, resulting in the secretion of factors associated with long-term diseases such as vascular disorders and cancer. We previously demonstrated that HCMV infection alters the types and quantities of bioactive proteins released from cells (designated the HCMV secretome) that are involved in the promotion of angiogenesis and wound healing. A key proangiogenic and antiapoptotic factor identified from a proteomic-based approach was IL-6. In the present report, we show for the first time that HCMV UL7 encodes a soluble molecule that is a structural and functional homologue of the CEACAM1 proangiogenic cellular factor. This report thereby identifies a critical component of the HCMV secretome that may be responsible, at least in part, for the vascular dysregulation associated with persistent HCMV infection
A characteristics framework for Semantic Information Systems Standards
Semantic Information Systems (IS) Standards play a critical role in the development of the networked economy. While their importance is undoubted by all stakeholders—such as businesses, policy makers, researchers, developers—the current state of research leaves a number of questions unaddressed. Terminological confusion exists around the notions of “business semantics”, “business-to-business interoperability”, and “interoperability standards” amongst others. And, moreover, a comprehensive understanding about the characteristics of Semantic IS Standards is missing. The paper addresses this gap in literature by developing a characteristics framework for Semantic IS Standards. Two case studies are used to check the applicability of the framework in a “real-life” context. The framework lays the foundation for future research in an important field of the IS discipline and supports practitioners in their efforts to analyze, compare, and evaluate Semantic IS Standard
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Novel epoxy-free construction method for fabricating dipole magnets and test results
Three model superconducting dipole magnets, lm length and having a bore diameter of 76mm, fabricated without epoxy resins or other adhesives, have been built and the first two have been tested in He I and He II. The conductor is the 23-strand Rutherford-type cable used in the Fermilab Doubler/Saver magnets, and is insulated with Mylar and Kapton. The two-layer winding is highly compessed by a system of structural support rings and tapered collets. Little training was required. Quench currents greater than 95% of short sample were obtained in He I with rise-times of 15 to 20 seconds to a central field of 4.6 T; 6.0 T in Helium II
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